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Статья; ОбзорИскать документыПерейти к записи. 2025 Фев. 15; Т. 32, № 1: 293–304. DOI:10.17816/vto322763
Местные кровоостанавливающие препараты в хирургии позвоночника. Обзор литературы
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Аффилированные организации
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Аннотация
Во время операции на позвоночнике важно добиться точного и быстрого гемостаза, чтобы сократить кровопотерю, время хирургического вмешательства и проведения анестезии, тем самым уменьшив частоту осложнений. Поэтому наличие современных, эффективных и безопасных местных гемостатических препаратов является важной основой успешной борьбы с этим осложнением, что, в свою очередь, приводит к уменьшению негативного влияния на пациента и снижает экономические затраты на его лечение. В данной статье мы проанализировали литературные данные о гемостатических препаратах, используемых в спинальной хирургии. На основе этих данных оценивались их эффективность и безопасность по отношению к пациенту, вероятность развития побочных эффектов. Дальнейшая разработка, усовершенствование и применение кровоостанавливающих препаратов должны быть сосредоточены на увеличении их эффективности и безопасности.
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Литература

Ramirez MG, Deutsch H, Khanna N, et al. Floseal only versus in combination in spine surgery: a comparative, retrospective hospital database evaluation of clinical and healthcare resource outcomes. Hosp Pract (1995). 2018;46(4):189–196. doi: 10.1080/21548331.2018.1498279.
DOI: 10.1080/21548331.2018.1498279

Szpalski M, Gunzburg R, Sztern B. An overview of blood-sparing techniques used in spine surgery during the perioperative period. Eur Spine J. 2004;13 Suppl 1(Suppl 1):S18–27. doi: 10.1007/s00586-004-0752-y.
DOI: 10.1007/s00586-004-0752-y

Signorelli F, Montano N. Use and Efficacy of Hemostats in Neurosurgery. Surg Technol Int. 2020;37:414–419.

Fineberg SJ, Oglesby M, Patel AA, Singh K. Incidence and mortality of perioperative cardiac events in cervical spine surgery. Spine (Phila Pa 1976). 2013;38(15):1268–74. doi: 10.1097/BRS.0b013e318290fdac.
DOI: 10.1097/BRS.0b013e318290fdac

Kimura A, Ohmori T, Sakata A, et al. Hemostatic function to regulate perioperative bleeding in patients undergoing spinal surgery: A prospective observational study. PLoS One. 2017;12(6):e0179829. doi: 10.1371/journal.pone.0179829.
DOI: 10.1371/journal.pone.0179829

Stokes ME, Ye X, Shah M, et al. Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients. BMC Health Serv Res. 2011;11:135. doi: 10.1186/1472-6963-11-135.
DOI: 10.1186/1472-6963-11-135

Zemlyanoj A.B. Sredstvo mestnogo gemostaza — tekuchaya aktivnaya gemostaticheskaya matrica. Hirurgiya. Zhurnal im. N.I. Pirogova. 2019;(5):104–115. (In Russ.). doi: 10.17116/hirurgia2019051104.
DOI: 10.17116/hirurgia2019051104

Vyas KS, Saha SP. Comparison of hemostatic agents used in vascular surgery. Expert Opin Biol Ther. 2013;13(12):1663–72. doi: 10.1517/14712598.2013.848193.
DOI: 10.1517/14712598.2013.848193

Le Huec JC, AlEissa S, Bowey AJ, et al. Hemostats in Spine Surgery: Literature Review and Expert Panel Recommendations. Neurospine. 2022;19(1):1–12. doi: 10.14245/ns.2143196.59.
DOI: 10.14245/ns.2143196.59

Tan H, Pan S, Wei C, Chen Z, Chen T. Comparative efficacy and safety of different hemostatic medications during spinal surgery: A network meta-analysis. Medicine (Baltimore). 2023;102(9):e32923. doi: 10.1097/MD.0000000000032923.
DOI: 10.1097/MD.0000000000032923

Korotkevich AG, Antonov YUA, Lobykin FI, Kuznecov VV. «Oksigeniruyushchij» gemostaz pri aktivnom yazvennom krovotechenii. Medicina v Kuzbasse. 2004;3(3):20–23. (In Russ.). EDN: KYOUPV

Chen H, Yang J-S, Zou P, et al. Safety and Efficacy of Hydrogen Peroxide in Controlling Blood Loss and Surgical Site Infection After Multisegmental Lumbar Spine Surgery: A Retrospective, Case-Controlled Study. World Neurosurg. 2020;133:e303–e307. doi: 10.1016/j.wneu.2019.09.005.
DOI: 10.1016/j.wneu.2019.09.005

Zou P, Yang J-S, Wang X-F, et al. Oxygen Embolism and Pneumocephalus After Hydrogen Peroxide Application During Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery: A Case Report and Literature Review. World Neurosurg. 2020;138:201–204. doi: 10.1016/j.wneu.2020.03.035.
DOI: 10.1016/j.wneu.2020.03.035

Zhao S-L, Zhang X-Y, Xiao Y, et al. Gas Embolism After Hydrogen Peroxide Use During Spine Surgery: Case Report and Literature Review. World Neurosurg. 2020;143:228–231. doi: 10.1016/j.wneu.2020.07.210.
DOI: 10.1016/j.wneu.2020.07.210

Mehta MH. The rib-vertebra angle in the early diagnosis between resolving and progressive infantile scoliosis. J Bone Joint Surg Br. 1972;54(2):230–43.

Li J, Wang L, Bai T, Liu Y, Huang Y. Combined use of intravenous and topical tranexamic acid efficiently reduces blood loss in patients aged over 60 operated with a 2-level lumbar fusion. J Orthop Surg Res. 2020;15(1):339. doi: 10.1186/s13018-020-01758-8.
DOI: 10.1186/s13018-020-01758-8

Xiong Z, Liu J, Yi P, Wang H, Tan M. Comparison of Intravenous versus Topical Tranexamic Acid in Nondeformity Spine Surgery: A Meta-Analysis. Biomed Res Int. 2020;2020:7403034. doi: 10.1155/2020/7403034.
DOI: 10.1155/2020/7403034

Eikebrokk TA, Vassmyr BS, Ausen K, et al. Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid. BJS Open. 2019;3(6):840–851. doi: 10.1002/bjs5.50192.
DOI: 10.1002/bjs5.50192

Neveleff DJ. Optimizing hemostatic practices: matching the appropriate hemostat to the clinical situation. AORN J. 2012;96(5):S1–S17. doi: 10.1016/j.aorn.2012.08.005.
DOI: 10.1016/j.aorn.2012.08.005

Spotnitz WD, Burks S. State-of-the-art review: Hemostats, sealants, and adhesives II: Update as well as how and when to use the components of the surgical toolbox. Clin Appl Thromb Hemost. 2010;16(5):497–514. doi: 10.1177/1076029610363589.
DOI: 10.1177/1076029610363589

Hickman DA, Pawlowski CL, Sekhon UDS, Marks J, Gupta A Sen. Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding. Adv Mater. 2018;30(4):10.1002/adma.201700859. doi: 10.1002/adma.201700859.
DOI: 10.1002/adma.201700859

Huang L, Liu GL, Kaye AD, Liu H. Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update. Adv Ther. 2020;37(10):4132–4148. doi: 10.1007/s12325-020-01467-y.
DOI: 10.1007/s12325-020-01467-y

Chiara O, Cimbanassi S, Bellanova G, et al. A systematic review on the use of topical hemostats in trauma and emergency surgery. BMC Surg. 2018;18(1):68. doi: 10.1186/s12893-018-0398-z.
DOI: 10.1186/s12893-018-0398-z

Echave M, Oyagüez I, Casado MA. Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review. MC Surg. 2014;14:111. doi: 10.1186/1471-2482-14-111.
DOI: 10.1186/1471-2482-14-111

Centeno A, Rojas S, Arias B, et al. Experimental Evaluation of a New Tissue Factor-Based Topical Hemostat (TT-173) for Treatment of Hepatic Bleeding. J Invest Surg. 2020;33(4):339–349. doi: 10.1080/08941939.2018.1517840.
DOI: 10.1080/08941939.2018.1517840

Lai M, Zhou S, He S, et al. Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery. Cochrane Database Syst Rev. 2023;6(6):CD009621. doi: 10.1002/14651858.
DOI: 10.1002/14651858

Bruckner BA, Blau LN, Rodriguez L, et al. Microporous polysaccharide hemosphere absorbable hemostat use in cardiothoracic surgical procedures. J Cardiothorac Surg. 2014;9:134. doi: 10.1186/s13019-014-0134-4.
DOI: 10.1186/s13019-014-0134-4

Wright NM, Park J, Tew JM, et al. Spinal sealant system provides better intraoperative watertight closure than standard of care during spinal surgery: a prospective, multicenter, randomized controlled study. Spine (Phila Pa 1976). 2015;40(8):505–13. doi: 10.1097/BRS.0000000000000810.
DOI: 10.1097/BRS.0000000000000810

Xiong GX, Tobert D, Fogel H, et al. Open epidural blood patch to augment durotomy repair in lumbar spine surgery: surgical technique and cohort study. Spine J. 2021;21(12):2010–2018. doi: 10.1016/j.spinee.2021.06.011.
DOI: 10.1016/j.spinee.2021.06.011

Sundaram CP, Keenan AC. Evolution of hemostatic agents in surgical practice. Indian J Urol. 2010;26(3):374–8. doi: 10.4103/0970-1591.70574.
DOI: 10.4103/0970-1591.70574

Mikhail C, Pennington Z, Arnold PM, et al Minimizing Blood Loss in Spine Surgery. Global Spine J. 2020;10(1 Suppl):71S–83S. doi: 10.1177/2192568219868475.
DOI: 10.1177/2192568219868475

Schonauer C, Tessitore E, Barbagallo G, Albanese V, Moraci A. The use of local agents: Bone wax, gelatin, collagen, oxidized cellulose. Eur Spine J. 2004;13 Suppl 1(Suppl 1):S89–96. doi: 10.1007/s00586-004-0727-z.
DOI: 10.1007/s00586-004-0727-z

Le Huec JC, Aleissa S, Bowey AJ, et al. Hemostats in Spine Surgery: Literature Review and Expert Panel Recommendations. Neurospine. 2022;19(1):1–12. doi: 10.14245/ns.2143196.598.
DOI: 10.14245/ns.2143196.598

Song Y, Nagai N, Saijo S, et al. In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery. Mater Sci Eng C Mater Biol Appl. 2018;88:1–12. doi: 10.1016/j.msec.2018.02.022.
DOI: 10.1016/j.msec.2018.02.022

Ji P, Jiang Y, Hou W, Li Q, Kang Y. A Rare Case of Fatal Pulmonary Embolism in a Pediatric Spine Surgery. World Neurosurg. 2020;137:183–186. doi: 10.1016/j.wneu.2020.01.225.
DOI: 10.1016/j.wneu.2020.01.225

Skovrlj B, Mascitelli JR, Camins MB, Doshi AH, Qureshi SA. Acute respiratory failure from Surgifoam expansion after anterior cervical surgery: case report. J Neurosurg Spine. 2013;19(4):428–30. doi: 10.3171/2013.7.SPINE1328.
DOI: 10.3171/2013.7.SPINE1328

Alander DH, Stauffer ES. Gelfoam-induced acute quadriparesis after cervical decompression and fusion. Spine (Phila Pa 1976). 1995;20(8):970–1. doi: 10.1097/00007632-199504150-00016.
DOI: 10.1097/00007632-199504150-00016

Friedman J, Whitecloud TS 3rd. Lumbar cauda equina syndrome associated with the use of gelfoam: case report. Spine (Phila Pa 1976). 2001;26(20):E485–7. doi: 10.1097/00007632-200110150-00029.
DOI: 10.1097/00007632-200110150-00029

Haws BE, Khechen B, Patel D V, et al. Impact of local steroid application in a minimally invasive transforaminal lumbar interbody fusion: results of a prospective, randomized, single-blind trial. J Neurosurg Spine. 2018;30(2):222–227. doi: 10.3171/2018.7.SPINE18584.
DOI: 10.3171/2018.7.SPINE18584

Liang J, Liu H, Huang X, et al. Using tranexamic acid soaked absorbable gelatin sponge following complex posterior lumbar spine surgery: A randomized control trial. Clin Neurol Neurosurg. 2016;147:110–4. doi: 10.1016/j.clineuro.2016.06.001.
DOI: 10.1016/j.clineuro.2016.06.001

Bessette MC, Mesfin A. Cauda equina syndrome caused by retained hemostatic agents. J Clin Neurosci. 2015;22(9):1518–20. doi: 10.1016/j.jocn.2015.03.021.
DOI: 10.1016/j.jocn.2015.03.021

Rustagi T, Patel K, Kadrekar S, Jain A. Oxidized Cellulose (Surgicel) Causing Postoperative Cauda Equine Syndrome. Cureus. 2017;9(7):e1500. doi: 10.7759/cureus.1500.
DOI: 10.7759/cureus.1500

Abbott WM, Austen WG. The effectiveness and mechanism of collagen-induced topical hemostasis. Surgery. 1975;78(6):723–9.

Lewis KM, Spazierer D, Slezak P, et al. Swelling, sealing, and hemostatic ability of a novel biomaterial: A polyethylene glycol-coated collagen pad. J Biomater Appl. 2014;29(5):780–8. doi: 10.1177/0885328214545500.
DOI: 10.1177/0885328214545500

Zhang S, Li J, Chen S, et al. Oxidized cellulose-based hemostatic materials. Carbohydr Polym. 2020;230:115585. doi: 10.1016/j.carbpol.2019.115585.
DOI: 10.1016/j.carbpol.2019.115585

Sae-Jung S, Apiwatanakul P. Chitosan Pad, Cellulose Membrane, or Gelatin Sponge for Peridural Bleeding: An Efficacy Study on a Lumbar Laminectomized Rat Model. Asian Spine J. 2018;12(2):195–201. doi: 10.4184/asj.2018.12.2.195.
DOI: 10.4184/asj.2018.12.2.195

Cheng F, Wu Y, Li H, et al. Biodegradable N, O-carboxymethyl chitosan/oxidized regenerated cellulose composite gauze as a barrier for preventing postoperative adhesion. Carbohydr Polym. 2019;207:180–190. doi: 10.1016/j.carbpol.2018.10.077.
DOI: 10.1016/j.carbpol.2018.10.077

Roshkovan L, Singhal S, Katz SI, Galperin-Aizenberg M. Multimodality imaging of Surgicel(®), an important mimic of post-operative complication in the thorax. BJR Open. 2021;3(1):20210031. doi: 10.1259/bjro.20210031.
DOI: 10.1259/bjro.20210031

Corti MC, Thomas AD, Sayegh MN, et al. Surgicel-Induced Anaphylaxis Post Permacath Placement. Cureus. 2021;13(8):e16938. doi: 10.7759/cureus.1693.
DOI: 10.7759/cureus.1693

Azami Hassani FE-Z, Slimani F. SURGICEL mimicking a recurrence of a temporomandibular joint chondrosarcoma. Ann Med Surg (Lond). 2021;63:102187. doi: 10.1016/j.amsu.2021.102187.
DOI: 10.1016/j.amsu.2021.102187

Turkyilmaz Z, Karabulut R, Kaya C, et al. Surgicel mimicking recurrent pelvic neuroblastoma in a 3-year-old boy. Acta Chir Belg. 2022;122(4):266–268. doi: 10.1080/00015458.2020.1846944.
DOI: 10.1080/00015458.2020.1846944

Sabel M, Stummer W. The use of local agents: Surgicel and Surgifoam. Eur Spine J. 2004;13 Suppl 1(Suppl 1):S97–101. doi: 10.1007/s00586-004-0735-z.
DOI: 10.1007/s00586-004-0735-z

Kovalenko RA, Ptashnikov DA, Savello AV, et al. A rare case of treatment of giant paravertebral arteriovenous malformation combined with idiopathic scoliosis. Spine Surgery. 2019;16(3):47–54. doi: 10.14531/ss2019.3.47-54.
DOI: 10.14531/ss2019.3.47-54

Slezak P, Keibl C, Labahn D, et al. A Comparative Efficacy Evaluation of Recombinant Topical Thrombin (RECOTHROM(®)) With A Gelatin Sponge Carrier Versus Topical Oxidized Regenerated Cellulose (TABOTAMP(®)/SURGICEL(®)) In A Porcine Liver Bleeding Model. J Invest Surg. 2021;34(8):862–868. doi: 10.1080/08941939.2019.1705444.
DOI: 10.1080/08941939.2019.1705444

Ahn DK, Shin WS, Kim GW, Koo KH. Postoperative Spinal Epidural Hematoma: The Danger Caused by the Misuse of Thrombin-Containing Local Hemostatics. Asian Spine J. 2017;11(6):898–902. doi: 10.4184/asj.2017.11.6.898.
DOI: 10.4184/asj.2017.11.6.898

Rodgers GM. Immune-mediated coagulopathy associated with topical bovine thrombin: review of the pediatric literature. J Pediatr Hematol Oncol. 2011;33(2):86–8. doi: 10.1097/MPH.0b013e3181ff0e43.
DOI: 10.1097/MPH.0b013e3181ff0e43

Park HJ, Suk KS, Park JW. A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin. Allergy Asthma Immunol Res. 2018;10(2):184–186. doi: 10.4168/aair.2018.10.2.184.
DOI: 10.4168/aair.2018.10.2.184

Minkowitz H, Navarro-Puerto J, Lakshman S, et al. Prospective, Randomized, Phase II, Non-Inferiority Study to Evaluate the Safety and Efficacy of Topical Thrombin (Human) Grifols as Adjunct to Hemostasis During Vascular, Hepatic, Soft Tissue, and Spinal Open Surgery. J Am Coll Surg. 2019;229(5):497–507.e1. doi: 10.1016/j.jamcollsurg.2019.07.008.
DOI: 10.1016/j.jamcollsurg.2019.07.008

Landi A, Gregori F, Marotta N, Delfini R. Efficacy, Security, and Manageability of Gelified Hemostatic Matrix in Bleeding Control during Thoracic and Lumbar Spine Surgery: FloSeal versus Surgiflo. J Neurol Surg A Cent Eur Neurosurg. 2016;77(2):139–43. doi: 10.1055/s-0035-1558413.
DOI: 10.1055/s-0035-1558413

Danker W, Kelkar SS, Marston XL, Aggarwal J, Johnston SS. Real-world economic and clinical outcomes associated with current hemostatic matrix use in spinal surgery. J Comp Eff Res. 2022;11(17):1231–1240. doi: 10.2217/cer-2021-0218.
DOI: 10.2217/cer-2021-0218

Nechepurenko AA, Ilov NN, Durmanov SS, et al. Application of Hemostatic Agent “Haemoblock” for Pocket Hematoma Reduction. Design of the PEGAS study: a Multicenter Clinical Trial. Card Arrhythm. 2021;1(1):17–24. (In Russ.). doi: 10.17816/cardar70497.
DOI: 10.17816/cardar70497

Plotkin AV, Pokrovskij EZH, Voronova GV, Menglet KA. Ocenka effektivnosti gemostaticheskogo dejstviya preparata Gemoblok pri polostnyh i laparoskopicheskih vmeshatel’stvah: mul’ticentrovye klinicheskie issledovaniya. Vestnik sovremennoj klinicheskoj mediciny. 2015;8(1):56–61. (In Russ.). EDN: THWGPP

Kuznecova MV, Parshakov AA, Kuznecova MP, et al. Vliyanie hirurgicheskogo gemostaticheskogo preparata «Gemoblok» na bakterial’nuyu kolonizaciyu in vitro. Klinicheskaya mikrobiologiya i antimikrobnaya himioterapiya. 2020;22(1):67–70. (In Russ.). doi: 10.36488/cmac.2020.1.67-70.
DOI: 10.36488/cmac.2020.1.67-70

Bajrikov I, Blohina EV. Ispol’zovanie medicinskogo preparata “GEMOBLOK DENT” u bol’nyh s gemofiliej v stomatologii. Sovremennaya nauka: aktual’nye problemy teorii i praktiki. Seriya: Estestvennye i tekhnicheskie nauki. 2019;(8):146–148. (In Russ.). EDN: XMITSS

Polyancev AA, Kaplunova EV, Karpenko SN, Linchenko AM. Pervyj opyt klinicheskogo primeneniya gemostaticheskogo sredstva « GEMOBLOK » pri endosokpicheskom gemostaze. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2015;(2):32–33. (In Russ.). EDN: TXGOIJ

Dumville JC, Coulthard P, Worthington HV, et al. Tissue adhesives for closure of surgical incisions. Cochrane Database Syst Rev. 2014;2014(11):CD004287. doi: 10.1002/14651858.CD004287.pub4.
DOI: 10.1002/14651858.CD004287.pub4

Yamagami T, Kanda K, Kato T, et al. Embolisation of proximal anastomotic pseudoaneurysm developing after surgical repair of abdominal aortic aneurysm with a bifurcated graft with n-butyl cyanoacrylate. Br J Radiol. 2006;79(948):e193–5. doi: 10.1259/bjr/97367208.
DOI: 10.1259/bjr/97367208

Tan T, Rutges J, Marion T, Hunn M, Tee J. Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis. Global Spine J. 2020;10(4):493–498. doi: 10.1177/2192568219861619.
DOI: 10.1177/2192568219861619

Ando M, Tamaki T, Yoshida M, et al. Surgical site infection in spinal surgery: a comparative study between 2-octyl-cyanoacrylate and staples for wound closure. Eur Spine J. 2014;23(4):854–62. doi: 10.1007/s00586-014-3202-5.
DOI: 10.1007/s00586-014-3202-5

Pace Napoleone C, Oppido G, Angeli E, Gargiulo G. Resternotomy in pediatric cardiac surgery: CoSeal initial experience. Interact Cardiovasc Thorac Surg. 2007;6(1):21–3. doi: 10.1510/icvts.2006.141531.
DOI: 10.1510/icvts.2006.141531

Kolesov SV, Grin AA, Slinyakov LY, et al. Effektivnost’ ispol’zovaniya serebryanoj soli poliakrilovoj kisloty pri dekompressionno- stabiliziruyushchih operaciyah na poyasnichnom otdele pozvonochnika s zahvatom 1–3 segmentov. Hirurgiya pozvonochnika. 2019;16(2):73–80. (In Russ.). doi: 10.14531/ss2019.2.73-80.
DOI: 10.14531/ss2019.2.73-80

Baird EO, McAnany SJ, Lu Y, Overley SC, Qureshi SA. Hemostatic Agents in Spine Surgery: A Critical Analysis Review. JBJS Rev. 2015;3(1):e2. doi: 10.2106/JBJS.RVW.N.00027.
DOI: 10.2106/JBJS.RVW.N.00027

Дополнительная информация
Язык текста: Русский
ISSN: 0869-8678
Унифицированный идентификатор ресурса для цитирования: //medj.rucml.ru/journal/45562d5052494f524f56545241554d4f52542d41525449434c452d333232373633/