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Статья; ОбзорИскать документыПерейти к записи. 2024; Т. 58, № 4-2: 8–19. DOI:10.31363/2313-7053-2024-1005
Воспаление как связующее звено между депрессией и метаболическим синдромом
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Аннотация

Депрессия вносит основной вклад в общее глобальное бремя болезней, в том числе, и по причине повышенного риска развития широкого круга сопутствующей соматической патологии—высокий процент смертности психиатрических пациентов обусловлен физическими заболеваниями, преимущественно сердечно-сосудистыми (ССЗ). Одним из факторов риска развития ССЗ и частым коморбидным депрессии состоянием является метаболический синдром (МС). Целью данного обзора является систематизация данных о взаимосвязи МС и депрессии, в частности, за счет общих патогенетических механизмов—системного воспаления. В статье поднимается вопрос использования гематологических коэффициентов системного воспаления (ГКСВ) в диагностике как МС, так и аффективной патологии, а также приводятся данные о новых комбинированных показателях, включающих клеточное звено и показатели липидограммы.

К последним относятся соотношения лимфоцитов и липопротеинов высокой плотности (ЛПВП) (Lymphocyte To High-Density Lipoprotein Ratio, LHR), нейтрофилов/ЛПВП (Neutrophil To High-Density Lipoprotein Ratio, NHR), тромбоцитов/ЛПВП (Platelet To High-Density Lipoprotein Ratio, PHR) и моноцитов/ЛПВП (Monocyte To High-Density Lipoprotein Ratio, MHR). Понимание связи между гематологическими коэффициентами и метаболическим синдромом у пациентов с депрессией может помочь в выявлении лиц с высоким риском его развития и определении своевременных профилактических мер. Различные клинические испытания и проведенные исследования указывают на связь между гематологическими параметрами и метаболическим синдромом, однако, вопрос выбора наиболее эффективных коэффициентов остается открытым. Дальнейшее изучение проблемы может помочь выявить потенциальные риски коморбидных нарушений и проводить своевременные профилактические мероприятия.

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Литература

Алексеева Н.С., Салмина-Хвостова О.И. Аффективные расстройства у пациентов с метаболическим синдромом. Acta Biomedica Scientifica. 2014;5(99):9-12

Горбунова А.П., Рукавишников Г.В., Касьянов Е.Д., Мазо Г.Э. Роль клеточного иммунитета и коэффициентов системного воспаления в механизмах формирования психических рас- стройств. Неврология, нейропсихиатрия, пси- хосоматика. 2023;15(5):72-78. https://doi.org/10.14412/2074-2711-2023-5-72-78.
DOI: 10.14412/2074-2711-2023-5-72-78

Горбунова А.П., Рукавишников Г.В., Касьянов Е.Д., Мазо Г.Э. Роль гематологических коэффициентов системного воспаления в диагностике и оценке риска аффективных расстройств. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2024;58(1):47-55..
DOI: 10.31363/2313-7053-2024-794

Дубинина Е.Е., Щедрина Л.В., Мазо Г.Э. Основные биохимические аспекты патогенеза депрессии. Часть 1. Успехи физиологических наук. 2018;49(1):28-49.

Дубинина Е.Е., Щедрина Л.В., Мазо Г.Э. Основные биохимические аспекты патогенеза депрессии. Часть II. Успехи физиологических наук. 2021; 52 (1): 31-48.

Мазо Г.Э., Шманева Т.М. Факторы риска фармакогенной прибавки веса у пациентов с депрессивным расстройством. Обзоры по клинич. фармакол. и лек. терапии. 2010;1:15-20.

Незнанов Н.Г., Мазо Г.Э., Кибитов А.О., Рукавишников Г.В. Депрессия и риск развития соматических заболеваний. Руководство для врачей. Москва: Специальное Издательство Медицинских Книг. 2018.

Akboga MK, Canpolat U, Yuksel M, et al. Platelet to lymphocyte ratio as a novel indicator of inflammation is correlated with the severity of metabolic syndrome: A single center large-scale study. Platelets. 2016;27(2):178-183. https://doi.org/10.3109/09537104.2015.1064518.
DOI: 10.3109/09537104.2015.1064518

Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition. Lancet. 2005;366(9491):1059-1062. https://doi.org/10.1016/S0140-6736(05)67402-8.
DOI: 10.1016/S0140-6736(05)67402-8

Bahadır A, Baltacı D, Türker Y, et al. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?. Anatol J Cardiol. 2015;15(10):816-822. https://doi.org/10.5152/akd.2014.5787.
DOI: 10.5152/akd.2014.5787

Battaglia S, Scialpi N, Berardi E, et al. Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects. PLoS One. 2020;15(4):e0231927. https://doi.org/10.1371/journal.pone.0231927.
DOI: 10.1371/journal.pone.0231927

Björntorp P. Do stress reactions cause abdominal obesity and comorbidities?. Obes Rev. 2001;2(2):73-86. https://doi.org/10.1046/j.1467-789x.2001.00027.x.
DOI: 10.1046/j.1467-789x.2001.00027.x

Bukrinsky MI, Mukhamedova N, Sviridov D. Lipid rafts and pathogens: the art of deception and ex- ploitation. J Lipid Res. 2020;61(5):601-610. https://doi.org/10.1194/jlr.TR119000391.
DOI: 10.1194/jlr.TR119000391

Chen H, Xiong C, Shao X, et al. Lymphocyte To High-Density Lipoprotein Ratio As A New Indi- cator Of Inflammation And Metabolic Syndrome. Diabetes Metab Syndr Obes. 2019;12:2117-2123. https://doi.org/10.2147/DMSO.S219363.
DOI: 10.2147/DMSO.S219363

Chen J, Huang Y, Li X. The association between lymphocyte to high-density lipoprotein ratio and depression: Data from NHANES 2015-2018. Brain Behav. 2024;14(3):e3467. https://doi.org/10.1002/brb3.3467.
DOI: 10.1002/brb3.3467

Chen T, Chen H, Xiao H, et al. Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China. Diabetes Metab Syndr Obes. 2020;13:597-605. https://doi.org/10.2147/DMSO.S238990.
DOI: 10.2147/DMSO.S238990

Cheng N, Ma H, Zhang K, Zhang C, Geng D. The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia. Medicina (Kaunas). 2023;59(3):503. https://doi.org/10.3390/medicina59030503.
DOI: 10.3390/medicina59030503

Cogny A, Atger V, Paul JL, Soni T, Moatti N. High-density lipoprotein 3 physicochemical modifications induced by interaction with human polymorphonuclear leucocytes affect their ability to remove cholesterol from cells. Biochem J. 1996;314(Pt 1):285-292. https://doi.org/10.1042/bj3140285.
DOI: 10.1042/bj3140285

Curcic S, Holzer M, Frei R, et al. Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL. Biochim Biophys Acta. 2015;1851(2):184-193. https://doi.org/10.1016/j.bbalip.2014.11.010.
DOI: 10.1016/j.bbalip.2014.11.010

Curcic S, Holzer M, Pasterk L, et al. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation. Sci Rep. 2017;7(1):8030. https://doi.org/10.1038/s41598-017-08136-1.
DOI: 10.1038/s41598-017-08136-1

Davidson K, Jonas BS, Dixon KE, Markovitz JH. Do depression symptoms predict early hypertension incidence in young adults in the CARDIA study? Coronary Artery Risk Development in Young Adults. Arch Intern Med. 2000;160(10):1495-1500. https://doi.org/10.1001/archinte.160.10.1495.
DOI: 10.1001/archinte.160.10.1495

Del Bosque-Plata L, Amin M, Wu R, Postolache TT, Gragnoli C. Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity. Eur Rev Med Pharmacol Sci. 2023;27(2):694-703. https://doi.org/10.26355/eurrev_202301_31072.
DOI: 10.26355/eurrev_202301_31072

DeLoach S, Keith SW, Gidding SS, Falkner B. Obesity associated inflammation in African American adolescents and adults. Am J Med Sci. 2014;347(5):357-363. https://doi.org/10.1097/MAJ.0b013e31829555f0.
DOI: 10.1097/MAJ.0b013e31829555f0

Després JP. Is visceral obesity the cause of the metabolic syndrome?. Ann Med. 2006;38(1):52-63. https://doi.org/10.1080/07853890500383895.
DOI: 10.1080/07853890500383895

Esmaili H, Bahreynian M, Qorbani M, et al. Prevalence of General and Abdominal Obesity in a Nationally Representative Sample of Iranian Children and Adolescents: The CASPIAN-IV Study. Iran J Pediatr. 2015;25(3):e401. https://doi.org/10.5812/ijp.25(3)2015.401.
DOI: 10.5812/ijp.25(3)2015.401

Fiske A, Wetherell JL, Gatz M. Depression in older adults. Annu Rev Clin Psychol. 2009;5:363-389. https://doi.org/10.1146/annurev.clinpsy.032408.153621.
DOI: 10.1146/annurev.clinpsy.032408.153621

Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83(3):847-850. https://doi.org/10.1210/jcem.83.3.4660.
DOI: 10.1210/jcem.83.3.4660

Greaves DR, Gordon S. The macrophage scaven- ger receptor at 30 years of age: current knowledge and future challenges. J Lipid Res. 2009;50(Sup- pl):282-286. https://doi.org/10.1194/jlr.R800066-JLR200.
DOI: 10.1194/jlr.R800066-JLR200

Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: anAmerican Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735-2752. https://doi.org/10.1161/CIRCULA-TIONAHA.105.169404.
DOI: 10.1161/CIRCULA-TIONAHA.105.169404

Harsanyi S, Kupcova I, Danisovic L, Klein M. Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?. Int J Mol Sci. 2022;24(1):578. https://doi.org/10.3390/ijms24010578.
DOI: 10.3390/ijms24010578

Heiskanen TH, Niskanen LK, Hintikka JJ, et al. Metabolic syndrome and depression: a cross-sectional analysis. J Clin Psychiatry. 2006;67(9):1422-1427. https://doi.org/10.4088/jcp.v67n0913.
DOI: 10.4088/jcp.v67n0913

Hu G, Qiao Q, Tuomilehto J, et al. Prevalence of the metabolic syndrome and its relation to allcause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med. 2004;164(10):1066-1076. https://doi.org/10.1001/archinte.164.10.1066.
DOI: 10.1001/archinte.164.10.1066

Huang JB, Chen YS, Ji HY, et al. Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study. Lipids Health Dis. 2020;19(1):59. https://doi.org/10.1186/s12944-020-01238-2.
DOI: 10.1186/s12944-020-01238-2

Imhof BA, Aurrand-Lions M. Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol. 2004;4(6):432-444. https://doi.org/10.1038/nri1375.
DOI: 10.1038/nri1375

Ji Y, Wang J, Chen H, Li J, Chen M. Association between hs-CRP and depressive symptoms: a cross-sec- tional study. Front Psychiatry. 2024;15:1339208. https://doi.org/10.3389/fpsyt.2024.1339208.
DOI: 10.3389/fpsyt.2024.1339208

Jialal I, Jialal G, Adams-Huet B. The platelet to high density lipoprotein -cholesterol ratio is a valid biomarker of nascent metabolic syndrome. Diabetes Metab Res Rev. 2021;37(6):e3403. https://doi.org/10.1002/dmrr.3403.
DOI: 10.1002/dmrr.3403

Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol. 2014;46(8):1619-1625. https://doi.org/10.1007/s11255-014-0730-1.
DOI: 10.1007/s11255-014-0730-1

Khandare SA, Chittawar S, Nahar N, Dubey TN, Qureshi Z. Study of Neutrophil-lymphocyte Ra- tio as Novel Marker for Diabetic Nephropathy in Type 2 Diabetes. Indian J Endocrinol Metab. 2017;21(3):387-392. https://doi.org/10.4103/ijem.IJEM_476_16.
DOI: 10.4103/ijem.IJEM_476_16

Kim DJ, Noh JH, Lee BW, et al. The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J Korean Med Sci. 2008;23(2):193-198. https://doi.org/10.3346/jkms.2008.23.2.193.
DOI: 10.3346/jkms.2008.23.2.193

Kolahi Ahari R, Akbari N, Babaeepoor N, et al. Association of Three Novel Inflammatory Mark- ers: Lymphocyte to HDL-C Ratio, High-Sensitivity C-Reactive Protein to HDL-C Ratio and High-Sensitivity C-Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome. Endocrinol Diabetes Metab. 2024;7(3):e00479. https://doi.org/10.1002/edm2.479.
DOI: 10.1002/edm2.479

Korkmaz ŞA, Kızgın S. Neutrophil/high-density lipoprotein cholesterol (HDL), monocyte/HDL and platelet/HDL ratios are increased in acute mania as markers of inflammation, even after controlling for confounding factors. Curr Med Res Opin. 2023;39(10):1383-1390. https://doi.org/10.1080/03007995.2023.2260302.
DOI: 10.1080/03007995.2023.2260302

Lago SG, Tomasik J, van Rees GF, et al. Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum. Brain Behav Immun. 2021;91:673-682. https://doi.org/10.1016/j.bbi.2020.07.043.
DOI: 10.1016/j.bbi.2020.07.043

Lerer B, Macciardi F, Segman RH, et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry. 2001;6(5):579-585. https://doi.org/10.1038/sj.mp.4000883.
DOI: 10.1038/sj.mp.4000883

Lin CC, Kardia SL, Li CI, et al. The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population. BMC Public Health. 2010;10:579. https://doi.org/10.1186/1471-2458-10-579.
DOI: 10.1186/1471-2458-10-579

Lin WY, Chen JD. The association between eosinophil count, serum lipids and metabolic syndrome in Taiwanese. Am J Med Sci. 2023;365(1):37-41. https://doi.org/10.1016/j.amjms.2022.07.015.
DOI: 10.1016/j.amjms.2022.07.015

Liu CC, Ko HJ, Liu WS, et al. Neutrophil-to-lympho- cyte ratio as a predictive marker of metabolic syn- drome. Medicine (Baltimore). 2019;98(43):e17537. https://doi.org/10.1097/MD.0000000000017537.
DOI: 10.1097/MD.0000000000017537

Liu Z, Fan Q, Wu S, Wan Y, Lei Y. Compared with the monocyte to high-density lipoprotein ratio (MHR) and the neutrophil to lymphocyte ratio (NLR), the neutrophil to high-density lipoprotein ratio (NHR) is more valuable for assessing the inflammatory process in Parkinson’s disease. Lipids Health Dis. 2021;20(1):35 https://doi.org/10.1186/s12944-021-01462-4.
DOI: 10.1186/s12944-021-01462-4

Love-Gregory L, Sherva R, Sun L, et al. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet. 2008;17(11):1695-1704. https://doi.org/10.1093/hmg/ddn060.
DOI: 10.1093/hmg/ddn060

Luquet S, Lopez-Soriano J, Holst D, et al. Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome. Biochimie. 2004;86(11):833-837. https://doi.org/10.1016/j.biochi.2004.09.024.
DOI: 10.1016/j.biochi.2004.09.024

Maes M, Smith R, Christophe A, et al. Lower se- rum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with im- mune-inflammatory markers. Acta Psychiatr Scand. 1997;95(3):212-221. https://doi.org/10.1111/j.1600-0447.1997.tb09622.x.
DOI: 10.1111/j.1600-0447.1997.tb09622.x

Mahmood A, Haider H, Samad S, et al. Association of white blood cell parameters with metabolic syndrome: A systematic review and meta-analysis of 168,000 patients. Medicine (Baltimore). 2024;103(10):e37331. https://doi.org/10.1097/MD.0000000000037331.
DOI: 10.1097/MD.0000000000037331

Marra A, Bondesan A, Caroli D, Sartorio A. Complete Blood Count (CBC)-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Adults with Severe Obesity. J Clin Med. 2024;13(5):1353. https://doi.org/10.3390/jcm13051353.
DOI: 10.3390/jcm13051353

Marra A, Bondesan A, Caroli D, Sartorio A. Complete Blood Count-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Children and Adolescents with Severe Obesity. J Clin Med. 2024;13(7):2120. https://doi.org/10.3390/jcm13072120.
DOI: 10.3390/jcm13072120

Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019;24(1):18-33. https://doi.org/10.1038/s41380-018-0017-5.
DOI: 10.1038/s41380-018-0017-5

Murphy AJ, Woollard KJ, Hoang A, et al. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol. 2008;28(11):2071-2077. https://doi.org/10.1161/ATVBAHA.108.168690.
DOI: 10.1161/ATVBAHA.108.168690

Nakamura H, Ito H, Egami Y, et al. Waist circumference is the main determinant of elevated C-re- active protein in metabolic syndrome. Diabetes Res Clin Pract. 2008;79(2):330-336. https://doi.org/10.1016/j.diabres.2007.09.004.
DOI: 10.1016/j.diabres.2007.09.004

Nicoară DM, Munteanu AI, Scutca AC, et al. Assessing the Relationship between Systemic Im- mune-Inflammation Index and Metabolic Syn- drome in Children with Obesity. Int J Mol Sci. 2023;24(9):8414. https://doi.org/10.3390/ijms24098414.
DOI: 10.3390/ijms24098414

Osimo EF, Baxter LJ, Lewis G, Jones PB, Khandaker GM. Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychol Med. 2019;49(12):1958-1970. https://doi.org/10.1017/S0033291719001454.
DOI: 10.1017/S0033291719001454

Pooley EC, Fairburn CG, Cooper Z, Sodhi MS, Cowen PJ, Harrison PJ. A 5-HT2C receptor promoter polymorphism (HTR2C—759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Am J Med Genet B Neuropsychiatr Genet. 2004;126B(1):124-127. https://doi.org/10.1002/ajmg.b.20143.
DOI: 10.1002/ajmg.b.20143

Prasanna Kumar KM. Metabolic syndrome. Int J Diabetes Dev Ctries. 2011; 31: 185–187. https://doi.org/10.1007/s13410-011-0056-9.
DOI: 10.1007/s13410-011-0056-9

Reaven GM. Banting lecture 1988. Role of in- sulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. https://doi.org/10.2337/diab.37.12.1595.
DOI: 10.2337/diab.37.12.1595

Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107(3):391-397. https://doi.org/10.1161/01.cir.0000055014.62083.05.
DOI: 10.1161/01.cir.0000055014.62083.05

Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342(12):836-843. https://doi.org/10.1056/NEJM200003233421202.
DOI: 10.1056/NEJM200003233421202

Rohatgi A. High-Density Lipoprotein Function Measurement in Human Studies: Focus on Cholesterol Efflux Capacity. Prog Cardiovasc Dis. 2015;58(1):32-40. https://doi.org/10.1016/j.pcad.2015.05.004.
DOI: 10.1016/j.pcad.2015.05.004

Rowan PJ, Haas D, Campbell JA, Maclean DR, Davidson KW. Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample. Ann Epidemiol. 2005;15(4):316-320. https://doi.org/10.1016/j.annepidem.2004.08.006.
DOI: 10.1016/j.annepidem.2004.08.006

Sanchez-Autet M, Arranz B, Sierra P, et al. Association between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and C-reactive protein levels and metabolic status in patients with a bipolar disorder. World J Biol Psychiatry. 2022;23(6):464-474. https://doi.org/10.1080/15622975.2021.2013089.
DOI: 10.1080/15622975.2021.2013089

Scherrer JF, Xian H, Bucholz KK, et al. A twin study of depression symptoms, hypertension, and heart disease in middle-aged men. Psychosom Med. 2003;65(4):548-557. https://doi.org/10.1097/01.psy.0000077507.29863.cb.
DOI: 10.1097/01.psy.0000077507.29863.cb

Scuteri A, Laurent S, Cucca F, et al. Metabolic syndrome across Europe: different clusters of risk factors. Eur J Prev Cardiol. 2015;22(4):486-491. https://doi.org/10.1177/2047487314525529.
DOI: 10.1177/2047487314525529

Skilton MR, Moulin P, Terra JL, Bonnet F. Associations between anxiety, depression, and the metabolic syndrome. Biol Psychiatry. 2007;62(11):1251-1257. https://doi.org/10.1016/j.biopsych.2007.01.012.
DOI: 10.1016/j.biopsych.2007.01.012

Solmi M, Suresh Sharma M, Osimo EF, et al. Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability. Brain Behav Immun. 2021;97:193-203. https://doi.org/10.1016/j.bbi.2021.07.014.
DOI: 10.1016/j.bbi.2021.07.014

Song Q, Wang SS, Zafari AM. Genetics of the Metabolic Syndrome. Hosp. Physician. 2006;42:51-61

Stentz FB, Kitabchi AE. Transcriptome and pro- teome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes. Genomics Proteomics Bioin- formatics. 2007;5(3-4):216-235. https://doi.org/10.1016/S1672-0229(08)60009-1.
DOI: 10.1016/S1672-0229(08)60009-1

Sun M, Zhang L, Chen S, Liu X, Shao X, Zou H. Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population. Int J Environ Res Public Health. 2015;12(7):8228-8242. https://doi.org/10.3390/ijerph120708228.
DOI: 10.3390/ijerph120708228

Surendar J, Indulekha K, Mohan V, Pradeepa R. Association of neutrophil-lymphocyte ratio with metabolic syndrome and its components in Asian Indians (CURES-143). J Diabetes Complications. 2016;30(8):1525-1529. https://doi.org/10.1016/j.jdiacomp.2016.08.006.
DOI: 10.1016/j.jdiacomp.2016.08.006

Syauqy A, Hsu CY, Rau HH, Chao JC. Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study. Nutr J. 2018;17(1):106. https://doi.org/10.1186/s12937-018-0417-z.
DOI: 10.1186/s12937-018-0417-z

Tang L, Peng H, Xu T, et al. Association of biomarkers of inflammation with dyslipidemia and its components among Mongolians in China. PLoS One. 2014;9(2):e89023. https://doi.org/10.1371/journal.pone.0089023.
DOI: 10.1371/journal.pone.0089023

Toledo A, Huang Z, Benach JL, London E. Analysis of Lipids and Lipid Rafts in Borrelia. Methods Mol Biol. 2018;1690:69-82. https://doi.org/10.1007/978-1-4939-7383-5_6.
DOI: 10.1007/978-1-4939-7383-5_6

Uslu AU, Sekin Y, Tarhan G, Canakcı N, Gunduz M, Karagulle M. Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome. Clin Appl Thromb Hemost. 2018;24(5):828-833. https://doi.org/10.1177/1076029617741362.
DOI: 10.1177/1076029617741362

Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lympho- cyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107(3):433-438. https://doi.org/10.1016/j.amjcard.2010.09.039.
DOI: 10.1016/j.amjcard.2010.09.039

van Reedt Dortland AK, Giltay EJ, van Veen T, van Pelt J, Zitman FG, Penninx BW. Associations between serum lipids and major depressive dis-order: results from the Netherlands Study of De- pression and Anxiety (NESDA). J Clin Psychiatry. 2010;71(6):729-736. https://doi.org/10.4088/JCP.08m04865blu.
DOI: 10.4088/JCP.08m04865blu

Vancampfort D, Stubbs B, Mitchell AJ, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry. 2015;14(3):339-347. https://doi.org/10.1002/wps.20252.
DOI: 10.1002/wps.20252

Vuong J, Qiu Y, La M, Clarke G, Swinkels DW, Cembrowski G. Reference intervals of complete blood count constituents are highly correlated to waist circumference: should obese patients have their own «normal values?». Am J Hematol. 2014;89(7):671-677. https://doi.org/10.1002/ajh.23713.
DOI: 10.1002/ajh.23713

Wang W, Chen ZY, Guo XL, Tu M. Monocyte to High-Density lipoprotein and Apolipoprotein A1 Ratios: Novel Indicators for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes. Front Endocrinol (Lausanne). 2022;13:935776. https://doi.org/10.3389/fendo.2022.935776.
DOI: 10.3389/fendo.2022.935776

Weber B, Schweiger U, Deuschle M, Heuser I. Major depression and impaired glucose tolerance. Exp Clin Endocrinol Diabetes. 2000;108(3):187-190. https://doi.org/10.1055/s-2000-7742.
DOI: 10.1055/s-2000-7742

Wei Y, Gao H, Luo Y, et al. Systemic inflammation and oxidative stress markers in patients with unipolar and bipolar depression: A large-scale study. J Affect Disord. 2024;346:154-166. https://doi.org/10.1016/j.jad.2023.10.156.
DOI: 10.1016/j.jad.2023.10.156

Wei Y, Wang T, Li G, et al. Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder. Front Psychiatry. 2022;13:941728 https://doi.org/10.3389/fpsyt.2022.941728.
DOI: 10.3389/fpsyt.2022.941728

World Health Organization. Depressive disorder (depression) [who.int]. who; 2023 [cited 21 June 2024]. Available: https://www.who.int/news-room/fact-sheets/detail/depressionhttps://www.who.int/news-room/fact-sheets/detail/depression

World Health Organization. Depressive disorder (depression) [who.int]. who; 2023 [cited 21 June 2024]. Available: https://www.who.int/news-room/fact-sheets/detail/depressionhttps://www.who.int/news-room/fact-sheets/detail/depression

Yasar Z, Buyuksirin M, Ucsular FD, et al. Is an elevated neutrophil-to-lymphocyte ratio a predictor of metabolic syndrome in patients with chronic obstructive pulmonary disease?. Eur Rev Med Pharmacol Sci. 2015;19(6):956-962.

Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9(4):299-304. https://doi.org/10.1016/j.dsx.2014.04.009.
DOI: 10.1016/j.dsx.2014.04.009

Yu S, Guo X, Li G, Yang H, Zheng L, Sun Y. Lymphocyte to High-Density Lipoprotein Ratio but Not Platelet to Lymphocyte Ratio Effectively Predicts Metabolic Syndrome Among Subjects From Rural China. Front Cardiovasc Med. 2021;8:583320. https://doi.org/10.3389/fcvm.2021.583320.
DOI: 10.3389/fcvm.2021.583320

Zhang SS, Yang XJ, Ma QH, et al. Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity. Sci Rep. 2021;11(1):4652. https://doi.org/10.1038/s41598-021-84367-7..
DOI: 10.1038/s41598-021-84367-7

Дополнительная информация
Язык текста: Русский
ISSN: 2313-7053
Унифицированный идентификатор ресурса для цитирования: //medj.rucml.ru/journal/4e432d42454b4854455245565245564945572d41525449434c452d323032342d35382d342d322d302d382d3139/