Fukuoka M., Wu Y.L., Thongprasert S., Sunpaweravong P., Leong S.S., Sriuranpong V. et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol. 2011;29(21):2866–2874. doi: 10.1200/JCO.2010.33.4235..
DOI: 10.1200/JCO.2010.33.4235
Zhou C., Wu Y.L., Chen G., Feng J., Liu X.-Q., Wang C. et al. Erlotinib versus chemotherapy as first‐line treatment for patients with advanced EGFR mutation‐positive non‐small‐cell lung cancer (OPTIMAL, CTONG‐0802): a multicentre, open‐label, randomised, phase 3 study. Lancet Oncol. 2011;12(8):735–742. doi: 10.1016/S1470-2045(11)70184-X..
DOI: 10.1016/S1470-2045(11)70184-X
Реутова Е.В., Лактионов К.П., Юдин Д.И., Нелюбина Л.А., Горохова Г.К., Егорова А.В. Осимертиниб в 1-й линии терапии EGFR-позитивного немелкоклеточного рака легкого. Современная онкология. 2019;21(3):17–20. doi: 10.26442/18151434.2019.3.190659..
DOI: 10.26442/18151434.2019.3.190659
Mok T.S., Wu Y.-L., Ahn M.-J., Garassino M.C., Kim H.R., Ramalingam S.S. et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017;376(7):629–640. doi: 10.1056/NEJMoa1612674..
DOI: 10.1056/NEJMoa1612674
Mok T.S., Wu Y.-L., Ahn M.-J., Garassino M.C., Kim H.R., Ramalingam S.S. et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017;376(7):629–640. doi: 10.1056/NEJMoa1612674..
DOI: 10.26442/18151434.2019.3.190659
Soria J.C., Ohe Y., Vansteenkiste J., Reungwetwattana T., Chewaskulyong B., Lee K.H. et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(2):113–125. doi: 10.1056/NEJMoa1713137..
DOI: 10.1056/NEJMoa1713137
Soria J.C., Ohe Y., Vansteenkiste J., Reungwetwattana T., Chewaskulyong B., Lee K.H. et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(2):113–125. doi: 10.1056/NEJMoa1713137..
DOI: 10.1056/NEJMoa1612674
Ramalingam S.S., Vansteenkiste J., Planchard D., Cho B.C., Gray J.E., Ohe Y. et al. Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC. N Engl J Med. 2020;382(1):41–50. doi: 10.1056/NEJMoa1913662..
DOI: 10.1056/NEJMoa1913662
Ramalingam S.S., Vansteenkiste J., Planchard D., Cho B.C., Gray J.E., Ohe Y. et al. Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC. N Engl J Med. 2020;382(1):41–50. doi: 10.1056/NEJMoa1913662..
DOI: 10.1056/NEJMoa1713137
Suda K., Mizuuchi H., Maehara Y., Mitsudomi T. Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation – diversity, ductility, and destiny. Cancer Metastasis Rev. 2012;31(3–4):807–814. doi: 10.1007/s10555-012-9391-7.pub4..
DOI: 10.1007/s10555-012-9391-7.pub4
Suda K., Mizuuchi H., Maehara Y., Mitsudomi T. Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation – diversity, ductility, and destiny. Cancer Metastasis Rev. 2012;31(3–4):807–814. doi: 10.1007/s10555-012-9391-7.pub4..
DOI: 10.1056/NEJMoa1913662
Sharma S.V., Bell D.W., Settleman J., Haber D.A. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007;7(3):169–181. doi: 10.1038/nrc2088..
DOI: 10.1038/nrc2088
Sharma S.V., Bell D.W., Settleman J., Haber D.A. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007;7(3):169–181. doi: 10.1038/nrc2088..
DOI: 10.1007/s10555-012-9391-7.pub4
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W. et al. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. NEJM. 2004;350(21):2129–2139. doi: 10.1056/NEJMoa040938..
DOI: 10.1056/NEJMoa040938
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W. et al. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. NEJM. 2004;350(21):2129–2139. doi: 10.1056/NEJMoa040938..
DOI: 10.1038/nrc2088
Paez J.G., Jänne P.A., Lee J.C., Tracy S., Greulich H., Gabriel S. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497–1500. doi: 10.1126/science.1099314..
DOI: 10.1126/science.1099314
Paez J.G., Jänne P.A., Lee J.C., Tracy S., Greulich H., Gabriel S. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497–1500. doi: 10.1126/science.1099314..
DOI: 10.1056/NEJMoa040938
Cheng L., Alexander R.E., Maclennan G.T., Cummings O.W., Montironi R., LopezBeltran A. et al. Molecular pathology of lung cancer: key to personalized medicine. Mod Pathol. 2012;25(3):347–369. doi: 10.1038/modpathol.2011.215..
DOI: 10.1038/modpathol.2011.215
Cheng L., Alexander R.E., Maclennan G.T., Cummings O.W., Montironi R., LopezBeltran A. et al. Molecular pathology of lung cancer: key to personalized medicine. Mod Pathol. 2012;25(3):347–369. doi: 10.1038/modpathol.2011.215..
DOI: 10.1126/science.1099314
Tjulandin S., Imyanitov E., Moiseyenko V., Ponomarenko D., Gurina L., Koroleva I., Karaseva V. Prospective cohort study of clinical characteristics and management patterns for patients with non-small-cell lung cancer in the Russian Federation: EPICLIN-Lung. Curr Med Res Opin. 2015;31(6):1117–1127. doi: 10.1185/03007995.2015.1036015..
DOI: 10.1185/03007995.2015.1036015
Tjulandin S., Imyanitov E., Moiseyenko V., Ponomarenko D., Gurina L., Koroleva I., Karaseva V. Prospective cohort study of clinical characteristics and management patterns for patients with non-small-cell lung cancer in the Russian Federation: EPICLIN-Lung. Curr Med Res Opin. 2015;31(6):1117–1127. doi: 10.1185/03007995.2015.1036015..
DOI: 10.1038/modpathol.2011.215
Planchard D., Popat S., Kerr K., Novello S., Smit E.F., Faivre-Finn C. et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(4 Suppl.):iv192–iv237. doi: 10.1093/annonc/mdy275..
DOI: 10.1093/annonc/mdy275
Planchard D., Popat S., Kerr K., Novello S., Smit E.F., Faivre-Finn C. et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(4 Suppl.):iv192–iv237. doi: 10.1093/annonc/mdy275..
DOI: 10.1185/03007995.2015.1036015
Ballard P., Yates J.W., Yang Z., Kim D.W., Yang J.C., Cantarini M. et al. Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity. Clin Cancer Res. 2016;22(20):5130–5140. doi: 10.1158/1078-0432.CCR-16-0399..
DOI: 10.1158/1078-0432.CCR-16-0399
Ballard P., Yates J.W., Yang Z., Kim D.W., Yang J.C., Cantarini M. et al. Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity. Clin Cancer Res. 2016;22(20):5130–5140. doi: 10.1158/1078-0432.CCR-16-0399..
DOI: 10.1093/annonc/mdy275
Togashi Y., Masago K., Masuda S., Mizuno T., Fukudo M., Ikemi Y. et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2012;70:399–405. doi: 10.1007/s00280-012-1929-4..
DOI: 10.1007/s00280-012-1929-4
Togashi Y., Masago K., Masuda S., Mizuno T., Fukudo M., Ikemi Y. et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2012;70:399–405. doi: 10.1007/s00280-012-1929-4..
DOI: 10.1158/1078-0432.CCR-16-0399
Hoffknecht P., Tufman A., Wehler T., Pelzer T., Wiewrodt R., Schütz M. et al. Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-pretreated non-smallcell lung cancer patients with brain metastases or leptomeningeal disease. J Thorac Oncol. 2015;10(1):156–163. doi: 10.1097/JTO.0000000000000380..
DOI: 10.1097/JTO.0000000000000380
Hoffknecht P., Tufman A., Wehler T., Pelzer T., Wiewrodt R., Schütz M. et al. Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-pretreated non-smallcell lung cancer patients with brain metastases or leptomeningeal disease. J Thorac Oncol. 2015;10(1):156–163. doi: 10.1097/JTO.0000000000000380..
DOI: 10.1007/s00280-012-1929-4
Batra U., Lokeshwar N., Gupta S., Shirsath P. Role of epidermal growth factor receptor-tyrosine kinase inhibitors in the management of central nervous system metastases in epidermal growth factor receptor mutation-positive nonsmall cell lung cancer patients. Indian J Cancer. 2017;54(Suppl.):S37–S44. doi: 10.4103/ijc.IJC_532_17..
DOI: 10.4103/ijc.IJC_532_17
Batra U., Lokeshwar N., Gupta S., Shirsath P. Role of epidermal growth factor receptor-tyrosine kinase inhibitors in the management of central nervous system metastases in epidermal growth factor receptor mutation-positive nonsmall cell lung cancer patients. Indian J Cancer. 2017;54(Suppl.):S37–S44. doi: 10.4103/ijc.IJC_532_17..
DOI: 10.1097/JTO.0000000000000380
Park S.J., Kim H.T., Lee D.H., Kim K.P., Kim S.W., Suh C., Lee J.S. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer. 2012;77(3):556–560. doi: 10.1016/j.lungcan.2012.05.092..
DOI: 10.1016/j.lungcan.2012.05.092
Park S.J., Kim H.T., Lee D.H., Kim K.P., Kim S.W., Suh C., Lee J.S. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer. 2012;77(3):556–560. doi: 10.1016/j.lungcan.2012.05.092..
DOI: 10.4103/ijc.IJC_532_17
Lee Y.J., Choi H.J., Kim S.K., Chang J., Moon J.W., Park I.K. et al. Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall cell lung cancer. Cancer. 2010;116(5):1336–1343. doi: 10.1002/cncr.24877..
DOI: 10.1002/cncr.24877
Lee Y.J., Choi H.J., Kim S.K., Chang J., Moon J.W., Park I.K. et al. Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall cell lung cancer. Cancer. 2010;116(5):1336–1343. doi: 10.1002/cncr.24877..
DOI: 10.1016/j.lungcan.2012.05.092
Peters S., Bexelius C., Munk V., Leighl N. The impact of brain metastasis on quality of life, resource utilization and survival in patients with non-small-cell lung cancer. Cancer Treat Rev. 2016;45:139–162. doi: 10.1016/j.ctrv.2016.03.009..
DOI: 10.1016/j.ctrv.2016.03.009
Peters S., Bexelius C., Munk V., Leighl N. The impact of brain metastasis on quality of life, resource utilization and survival in patients with non-small-cell lung cancer. Cancer Treat Rev. 2016;45:139–162. doi: 10.1016/j.ctrv.2016.03.009..
DOI: 10.1002/cncr.24877
Goss G., Tsai C.M., Shepherd F.A., Ahn M.J., Bazhenova L., Crinò L. et al. CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ann Oncol. 2018;29(3):687–693. doi: 10.1093/annonc/mdx820..
DOI: 10.1093/annonc/mdx820
Goss G., Tsai C.M., Shepherd F.A., Ahn M.J., Bazhenova L., Crinò L. et al. CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ann Oncol. 2018;29(3):687–693. doi: 10.1093/annonc/mdx820..
DOI: 10.1016/j.ctrv.2016.03.009
Wu Y.L., Ahn M.J., Garassino M.C., Han J.Y., Katakami N., Kim H.R. et al. CNS Efficacy of Osimertinib in Patients With T790M-Positive Advanced NonSmall-Cell Lung Cancer: Data From a Randomized Phase III Trial (AURA3). J Clin Oncol. 2018;36(26):2702–2709. doi: 10.1200/JCO.2018.77.9363..
DOI: 10.1200/JCO.2018.77.9363
Wu Y.L., Ahn M.J., Garassino M.C., Han J.Y., Katakami N., Kim H.R. et al. CNS Efficacy of Osimertinib in Patients With T790M-Positive Advanced NonSmall-Cell Lung Cancer: Data From a Randomized Phase III Trial (AURA3). J Clin Oncol. 2018;36(26):2702–2709. doi: 10.1200/JCO.2018.77.9363..
DOI: 10.1093/annonc/mdx820
Yang J.C., Ahn M.J., Kim D.W., Ramalingam S.S., Sequist L.V., Su W.C. et al. Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component. J Clin Oncol. 2017;35(12):1288–1296. doi: 10.1200/JCO.2016.70.3223..
DOI: 10.1200/JCO.2016.70.3223
Yang J.C., Ahn M.J., Kim D.W., Ramalingam S.S., Sequist L.V., Su W.C. et al. Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component. J Clin Oncol. 2017;35(12):1288–1296. doi: 10.1200/JCO.2016.70.3223..
DOI: 10.1200/JCO.2018.77.9363
Goss G., Tsai C.M., Shepherd F.A., Bazhenova L., Lee J.S., Chang G.C. et al. Osimertinib for pretreated EGFR Thr790Met-positive advanced non-smallcell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study. Lancet Oncol. 2016;17(12):1643–1652. doi: 10.1016/S1470-2045(16)30508-3..
DOI: 10.1016/S1470-2045(16)30508-3
Goss G., Tsai C.M., Shepherd F.A., Bazhenova L., Lee J.S., Chang G.C. et al. Osimertinib for pretreated EGFR Thr790Met-positive advanced non-smallcell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study. Lancet Oncol. 2016;17(12):1643–1652. doi: 10.1016/S1470-2045(16)30508-3..
DOI: 10.1200/JCO.2016.70.3223
Reungwetwattana T., Nakagawa K., Cho B.C., Cobo M., Cho E.K., Bertolini A. et al. CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with Untreated EGFRMutated advanced non-small-cell lung cancer. J Clin Oncol. 2018;36(33):3290–3297. doi: 10.1200/JCO.2018.78.3118..
DOI: 10.1200/JCO.2018.78.3118
Reungwetwattana T., Nakagawa K., Cho B.C., Cobo M., Cho E.K., Bertolini A. et al. CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with Untreated EGFRMutated advanced non-small-cell lung cancer. J Clin Oncol. 2018;36(33):3290–3297. doi: 10.1200/JCO.2018.78.3118..
DOI: 10.1016/S1470-2045(16)30508-3
Lee S.J., Lee J.I., Nam D.H., Ahn Y.C., Han J.H., Sun J.M. et al. Leptomeningeal carcinomatosis in non-small-cell lung cancer patients: impact on survival and correlated prognostic factors. J Thorac Oncol. 2013;8(2):185–191. doi: 10.1097/JTO.0b013e3182773f21..
DOI: 10.1097/JTO.0b013e3182773f21
Lee S.J., Lee J.I., Nam D.H., Ahn Y.C., Han J.H., Sun J.M. et al. Leptomeningeal carcinomatosis in non-small-cell lung cancer patients: impact on survival and correlated prognostic factors. J Thorac Oncol. 2013;8(2):185–191. doi: 10.1097/JTO.0b013e3182773f21..
DOI: 10.1200/JCO.2018.78.3118