Stratton I.M., Adler A.I., Neil H.A.W., Matthews D.R., Manley S.E, Cull C.A. et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405–412. https://doi.org/10.1136/bmj.321.7258.405..
DOI: 10.1136/bmj.321.7258.405
Kawanami D., Matoba K., Sango K., Utsunomiya K. Incretin-Based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence. Int J Mol Sci. 2016;17(8):1223. https://doi.org/10.3390/ijms17081223..
DOI: 10.3390/ijms17081223
Buse J.B., Wexler D.J., Tsapas A., Rossing P., Mingrone G., Mathieu C. et al. 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2020;43(7):1670. https://doi.org/10.2337/dci19-0066..
DOI: 10.2337/dci19-0066
Bayliss W., Starling E. The mechanism of pancreatic secretion. J Physiol. 1902;28(5):325–353. https://doi.org/10.1113/jphysiol.1902.sp000920..
DOI: 10.1113/jphysiol.1902.sp000920
Moore B. On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous Membrane. Biochem J. 1906;1(1):28–38. https://doi.org/10.1042/bj0010028..
DOI: 10.1042/bj0010028
Hartmann B., Johnsen A.H., Orskov C., Adelhorst K., Thim L., Holst J.J. Structure, measurement, and secretion of human glucagon-like peptide-2. Peptides. 2000;21(1):73–80. https://doi.org/10.1016/s0196-9781(99)00176-x..
DOI: 10.1016/s0196-9781(99)00176-x
Oduori O.S., Murao N., Shimomura K., Takahashi H., Zhang Q., Dou H. et al. Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes. J Clin Invest. 2020;130(12):6639–6655. https://doi.org/10.1172/JCI140046..
DOI: 10.1172/JCI140046
Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R. et al. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019;30:72–130. https://doi.org/10.1016/j.molmet.2019.09.010..
DOI: 10.1016/j.molmet.2019.09.010
Artasensi A., Pedretti A., Vistoli G., Fumagalli L. Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs. Molecules. 2020;25(8):1987. https://doi.org/10.3390/molecules25081987..
DOI: 10.3390/molecules25081987
Nauck M., Stöckmann F., Ebert R., Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29(1):46–52. https://doi.org/10.1007/BF02427280..
DOI: 10.1007/BF02427280
Eldor R., Raz I. The individualized target HbA1c: a new method for improving macrovascular risk and glycemia without hypoglycemia and weight gain. Rev Diabet Stud. 2009;6(1):6–12. https://doi.org/10.1900/RDS.2009.6.6..
DOI: 10.1900/RDS.2009.6.6
Davidson J.A. Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors. Cleve Clin J Med. 2009;76(5):S28–S38. https://doi.org/10.3949/ccjm.76.s5.05..
DOI: 10.3949/ccjm.76.s5.05
Dicker D. DPP-4 Inhibitors. Impact on glycemic control and cardiovascular risk factors. Diabetes Care. 2011;34(2):276–278. https://doi.org/10.2337/dc11-s229..
DOI: 10.2337/dc11-s229
Jeon J.Y., Ko S.H., Kwon H.S., Kim N.H., Kim J.H., Kim C.S. et al. Prevalence of diabetesand prediabetes according to fasting plasma glucose and HbA1c. Diabetes Metab J. 2013;37(5):349–357. https://doi.org/10.4093/dmj.2013.37.5.349..
DOI: 10.4093/dmj.2013.37.5.349
Plosker G.L. Sitagliptin: A review of its use in patientswith type 2 diabetes mellitus. Drugs. 2014;74(2):223–242. https://doi.org/10.1007/s40265013-0169-1..
DOI: 10.1007/s40265013-0169-1
Onge E.L., Miller S., Clements E. Sitagliptin/metformin (Janumet) as combination therapy in the treatment of type-2 diabetes mellitus. PT. 2012;37(12): 699–708. Available at: https://pubmed.ncbi.nlm.nih.gov/23319848/.https://pubmed.ncbi.nlm.nih.gov/23319848/
Herman G.A., Stevens C., Van Dyck K., Bergman А., Yi B., Smet М.D. et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005;78(6):675–688. https://doi.org/10.1016/j.clpt.2005.09.002..
DOI: 10.1016/j.clpt.2005.09.002
Raz I., Hanefeld M., Xu L., Caria C., Williams-Herman D., Khatami H.; Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49(11):2564–2571. https://doi.org/10.1007/s00125-006-0416-z..
DOI: 10.1007/s00125-006-0416-z
Mannucci E., Pala L., Ciani S., Bardini G., Pezzatini A., Sposato I. et al. Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus. Diabetologia. 2005;48(6):1168–1172. https://doi.org/10.1007/s00125-005-1749-8..
DOI: 10.1007/s00125-005-1749-8
Katsuno T., Ikeda H., Namba M. Medium-Term Effect of Add-On Therapy with the DPP-4 Inhibitor, Sitagliptin, in Insulin-Treated Japanese Patients with Type 2 Diabetes Mellitus. Diabetes Ther. 2016;7(2):309–320. https://doi.org/10.1007/s13300-016-0170-2..
DOI: 10.1007/s13300-016-0170-2
Hattori S. Sitagliptin reduces albuminuria in patients with type 2 diabetes. Endocr J. 2011;58(1):69–73. https://doi.org/10.1507/endocrj.k10e-382..
DOI: 10.1507/endocrj.k10e-382
Vincent S.H., Reed J.R., Bergman A.J., Elmore C.S., Zhu B., Xu S. et al. Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] sitagliptin in humans. Drug Metab Dispos. 2007;35(4):533–538. https://doi.org/10.1124/dmd.106.013136..
DOI: 10.1124/dmd.106.013136
Engel S.S., Golm G.T., Shapiro D., Davies M.J., Kaufman K.D., Goldstein B.J. Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus: a pooled analysis. Cardiovasc Diabetol. 2013;12:3. https://doi.org/10.1186/1475-2840-12-3..
DOI: 10.1186/1475-2840-12-3
Green J.B., Bethel M.A., Armstrong P.W., Buse J.B., Engel S.S., Garg J. et al. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015;373(3):232–242. https://doi.org/10.1056/NEJMoa1501352..
DOI: 10.1056/NEJMoa1501352
Bailey C.J., Campbell J.W., Chan J.C.N., Davidson J.A., Howlett H.C.S., Ritz P. Metformin. The Gold Standard: а Scientific Handbook. 2007. P. 37. Available at: https://research.aston.ac.uk/en/publications/metformin-the-gold-standard-a-scientific-handbook.https://research.aston.ac.uk/en/publications/metformin-the-gold-standard-a-scientific-handbook
LaMoia T.E., Shulman G.I. Cellular and Molecular Mechanisms of Metformin Action. Endocr Rev. 2021;42(1):77–96. https://doi.org/10.1210/endrev/bnaa023..
DOI: 10.1210/endrev/bnaa023
Migoya E.M., Bergeron R., Miller J.L., Snyder R.N., Tanen M., Hilliard D. et al. Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1. Clin Pharmacol Ther. 2010;88(6):801–808. https://doi.org/10.1038/clpt.2010.184..
DOI: 10.1038/clpt.2010.184
Maida A., Lamont B.J., Cao X., Drucker D.J. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice. Diabetologia. 2011;54(2):339–349. https://doi.org/10.1007/s00125-010-1937-z..
DOI: 10.1007/s00125-010-1937-z
Liu X., Wang L., Xing Y., Engel S.S., Zeng L., Yao B. et al. Efficacy and safety of metformin and sitagliptin-based dual and triple therapy in elderly Chinese patients with type 2 diabetes: Subgroup analysis of STRATEGY study. J Diabetes Investig. 2020;11(6):1532–1541. https://doi.org/10.1111/jdi.13277..
DOI: 10.1111/jdi.13277
Defronzo R.A. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773–795. https://doi.org/10.2337/db09-9028..
DOI: 10.2337/db09-9028
Goldstein B.J., Feinglos M.N., Lunceford J.K., Johnson J., Williams-Herman D.E. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30(8):1979–1987. https://doi.org/10.2337/dc07-0627..
DOI: 10.2337/dc07-0627
Reasner C., Olansky L., Seck T.L., Williams-Herman D.E., Chen M., Terranella L. et al. The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2011;13(7):644–652. https://doi.org/10.1111/j.1463-1326.2011.01390.x..
DOI: 10.1111/j.1463-1326.2011.01390.x
Seck T., Nauck M., Sheng D., Sunga S., Davies M.J., Stein P.P. et al., Sitagliptin Study 024 Group. Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study. Int J Clin Pract. 2010;64(5):562–576. https://doi.org/10.1111/j.1742-1241.2010.02353.x..
DOI: 10.1111/j.1742-1241.2010.02353.x
Standards of Medical Care in Diabetes-2016. Obesity Management for the Treatment of Type 2 Diabetes. Diabetes Care. 2016;39(S1):S47–S51. https://doi.org/10.2337/dc16-S009..
DOI: 10.2337/dc16-S009
Janani L., Bamehr H., Tanha K., Mirzabeigi P., Montazeri H., Tarighi P. Effects of Sitagliptin as Monotherapy and Add-On to Metformin on Weight Loss among Overweight and Obese Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Drug Res (Stuttg). 2021;71(9):477–488. https://doi.org/10.1055/a-1555-2797..
DOI: 10.1055/a-1555-2797
Janghorbani M., Van Dam R.M., Willett W.C., Hu F.B. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol. 2007;166(5):495–505. https://doi.org/10.1093/aje/kwm106..
DOI: 10.1093/aje/kwm106
Zhen D., Chen Y., Tang X. Metformin reverses the deleterious effects of high glucose on osteoblast function. J Diabetes Complications. 2010;24(5):334–344. https://doi.org/10.1016/j.jdiacomp.2009.05.002..
DOI: 10.1016/j.jdiacomp.2009.05.002
Henriksen D.B., Alexandersen P., Bjarnason N.H., Vilsbøll T., Hartmann B., Henriksen E.E. et al. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res. 2003;18(12):2180–2189. https://doi.org/10.1359/jbmr.2003.18.12.2180..
DOI: 10.1359/jbmr.2003.18.12.2180
Choi H.J., Park C., Lee Y.K., Ha Y.C., Jang S., Shin C.S. Risk of fractures and diabetes medications: a nationwide cohort study. Osteoporos Int. 2016;27(9):2709–2715. https://doi.org/10.1007/s00198-016-3595-6..
DOI: 10.1007/s00198-016-3595-6