Palella F.J., Delaney K.M., Moorman A.C., Loveless M.O., Fuhrer J., Satten G.A., Aschman D.J., Holmberg S.D., Investigators H.O.S. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. New Engl. J. Med., 1998. Vol. 338, No. 13, pp. 853–860. URL: ://WOS:000072669800001.://WOS:000072669800001
Palella F.J., Delaney K.M., Moorman A.C., Loveless M.O., Fuhrer J., Satten G.A., Aschman D.J., Holmberg S.D., Investigators H.O.S. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. New Engl. J. Med., 1998. Vol. 338, No. 13, pp. 853–860. URL: ://WOS:000072669800001.://WOS:000072669800001
Evans T.G., Bonnez W., Soucier H.R., Fitzgerald T., Gibbons D.C., Reichman R.C. Highly active antiretroviral therapy results in a decrease in CD8(+) T cell activation and preferential reconstitution of the peripheral CD4(+) T cell population with memory rather than I cells. Antivir. Res., 1998, Vol. 39, No. 3, pp. 163–173. URL: ://WOS:000076934000002.://WOS:000076934000002
Evans T.G., Bonnez W., Soucier H.R., Fitzgerald T., Gibbons D.C., Reichman R.C. Highly active antiretroviral therapy results in a decrease in CD8(+) T cell activation and preferential reconstitution of the peripheral CD4(+) T cell population with memory rather than I cells. Antivir. Res., 1998, Vol. 39, No. 3, pp. 163–173. URL: ://WOS:000076934000002.://WOS:000076934000002
Tilling R., Kinloch S., Goh L.E., Cooper D., Perrin L., Lampe F., Zaunders J., Hoen B., Tsoukas C., Andersson J., Janossy G., Grp Q.S. Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS, 2002, Vol. 16, No. 4, pp. 589–596. URL: ://WOS:000174367100010.://WOS:000174367100010
Tilling R., Kinloch S., Goh L.E., Cooper D., Perrin L., Lampe F., Zaunders J., Hoen B., Tsoukas C., Andersson J., Janossy G., Grp Q.S. Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS, 2002, Vol. 16, No. 4, pp. 589–596. URL: ://WOS:000174367100010.://WOS:000174367100010
Hileman C.O., Funderburg N.T. Inflammation, immune activation, and antiretroviral therapy in HIV. Curr. HIV/AIDS Rep., 2017, Vol. 14, No. 3, pp. 93–100. URL: https://www.ncbi.nlm.nih.gov/pubmed/28434169.https://www.ncbi.nlm.nih.gov/pubmed/28434169
Hileman C.O., Funderburg N.T. Inflammation, immune activation, and antiretroviral therapy in HIV. Curr. HIV/AIDS Rep., 2017, Vol. 14, No. 3, pp. 93–100. URL: https://www.ncbi.nlm.nih.gov/pubmed/28434169.https://www.ncbi.nlm.nih.gov/pubmed/28434169
Gulick R.M., Mellors J.W., Havlir D., Eron J.J., Gonzalez C., McMahon D., Richman D.D., Valentine F.T., Jonas L., Meibohm A., Emini E.A., Chodakewitz J.A. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. New Engl. J. Med., 1997, Vol. 337, No. 11, pp. 734–739. URL: ://WOS:A1997XV17400002.://WOS:A1997XV17400002
Gulick R.M., Mellors J.W., Havlir D., Eron J.J., Gonzalez C., McMahon D., Richman D.D., Valentine F.T., Jonas L., Meibohm A., Emini E.A., Chodakewitz J.A. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. New Engl. J. Med., 1997, Vol. 337, No. 11, pp. 734–739. URL: ://WOS:A1997XV17400002.://WOS:A1997XV17400002
Hammer S.M., Squires K.E., Hughes M.D., Grimes J.M., Demeter L.M., Currier J.S., Eron J.J., Feinberg J.E., Balfour H.H., Dayton L.R., Chodakewitz J.A., Fischl M.A. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. New Engl. J. Med., 1997, Vol. 337, No. 11, pp. 725–733. URL: ISI>://WOS:A1997XV17400001.ISI>://WOS:A1997XV17400001
Hammer S.M., Squires K.E., Hughes M.D., Grimes J.M., Demeter L.M., Currier J.S., Eron J.J., Feinberg J.E., Balfour H.H., Dayton L.R., Chodakewitz J.A., Fischl M.A. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. New Engl. J. Med., 1997, Vol. 337, No. 11, pp. 725–733. URL: ISI>://WOS:A1997XV17400001.ISI>://WOS:A1997XV17400001
Laskey S.B., Siliciano R.F. A mechanistic theory to explain the efficacy of antiretroviral therapy. Nat. Rev. Microbiol., 2014, Vol. 12, No. 11, pp. 772–780. URL: https://www.ncbi.nlm.nih.gov/pubmed/25263222.https://www.ncbi.nlm.nih.gov/pubmed/25263222
Laskey S.B., Siliciano R.F. A mechanistic theory to explain the efficacy of antiretroviral therapy. Nat. Rev. Microbiol., 2014, Vol. 12, No. 11, pp. 772–780. URL: https://www.ncbi.nlm.nih.gov/pubmed/25263222.https://www.ncbi.nlm.nih.gov/pubmed/25263222
Hill A.L., Rosenbloom D.I., Fu F., Nowak M.A., Siliciano R.F. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc. Natl. Acad. Sci. USA, 2014, Vol. 111, No. 37, pp. 13 475–13 480. URL: https://www.ncbi.nlm.nih.gov/pubmed/25097264.https://www.ncbi.nlm.nih.gov/pubmed/25097264
Hill A.L., Rosenbloom D.I., Fu F., Nowak M.A., Siliciano R.F. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc. Natl. Acad. Sci. USA, 2014, Vol. 111, No. 37, pp. 13 475–13 480. URL: https://www.ncbi.nlm.nih.gov/pubmed/25097264.https://www.ncbi.nlm.nih.gov/pubmed/25097264
Bucy R.P., Hockett R.D., Derdeyn C.A., Saag M.S., Squires K., Sillers M., Mitsuyasu R.T., Kilby J.M. Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J. Clin. Invest., 1999, Vol. 103, No. 10, pp. 1391–1398. URL: ://WOS:000083467200005.://WOS:000083467200005
Bucy R.P., Hockett R.D., Derdeyn C.A., Saag M.S., Squires K., Sillers M., Mitsuyasu R.T., Kilby J.M. Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J. Clin. Invest., 1999, Vol. 103, No. 10, pp. 1391–1398. URL: ://WOS:000083467200005.://WOS:000083467200005
Pakker N.G., Notermans D.W., de Boer R.J., Roos M.T.L., de Wolf F., Hill A., Leonard J.M., Danner S.A., Miedema F., Schellekens P.T.A. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat. Med., 1998, Vol. 4, No. 2, pp. 208–214. URL: ://WOS:000072249800037.://WOS:000072249800037
Pakker N.G., Notermans D.W., de Boer R.J., Roos M.T.L., de Wolf F., Hill A., Leonard J.M., Danner S.A., Miedema F., Schellekens P.T.A. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat. Med., 1998, Vol. 4, No. 2, pp. 208–214. URL: ://WOS:000072249800037.://WOS:000072249800037
Le Moing V., Thiebaut R., Chene G., Leport C., Cailleton V., Michelet C., Fleury H., Herson S., Raffi F., Group A.S. Predictors of long-term increase in CD4(+) cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen. J. Infect. Dis., 2002, Vol. 185, No. 4, pp. 471–480. URL: http://www.ncbi.nlm.nih.gov/pubmed/11865399.http://www.ncbi.nlm.nih.gov/pubmed/11865399
Le Moing V., Thiebaut R., Chene G., Leport C., Cailleton V., Michelet C., Fleury H., Herson S., Raffi F., Group A.S. Predictors of long-term increase in CD4(+) cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen. J. Infect. Dis., 2002, Vol. 185, No. 4, pp. 471–480. URL: http://www.ncbi.nlm.nih.gov/pubmed/11865399.http://www.ncbi.nlm.nih.gov/pubmed/11865399
Lok J.J., Bosch R.J., Benson C.A., Collier A.C., Robbins G.K., Shafer R.W., Hughes M.D., Team A. Long-term increase in CD4(+) T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS, 2010, Vol. 24, No. 12, pp. 1867–1876. URL: ISI>://WOS:000279697400008.ISI>://WOS:000279697400008
Lok J.J., Bosch R.J., Benson C.A., Collier A.C., Robbins G.K., Shafer R.W., Hughes M.D., Team A. Long-term increase in CD4(+) T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS, 2010, Vol. 24, No. 12, pp. 1867–1876. URL: ISI>://WOS:000279697400008.ISI>://WOS:000279697400008
Tchao N.K., Turka L.A. Lymphodepletion and Homeostatic Proliferation: Implications for Transplantation. Am. J. Transplant., 2012., Vol. 12., No. 5, pp. 1079–1090. URL: ://WOS:000303235100006.://WOS:000303235100006
Tchao N.K., Turka L.A. Lymphodepletion and Homeostatic Proliferation: Implications for Transplantation. Am. J. Transplant., 2012., Vol. 12., No. 5, pp. 1079–1090. URL: ://WOS:000303235100006.://WOS:000303235100006
Kieper W.C., Troy A., Burghardt J.T., Ramsey C., Lee J.Y., Jiang H.Q., Dummer W., Shen H., Cebra J.J., Surh C.D. Cutting edge: Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol., 2005, Vol. 174, No. 6, pp. 3158–3163. URL: ://WOS:000227510900005.://WOS:000227510900005
Kieper W.C., Troy A., Burghardt J.T., Ramsey C., Lee J.Y., Jiang H.Q., Dummer W., Shen H., Cebra J.J., Surh C.D. Cutting edge: Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol., 2005, Vol. 174, No. 6, pp. 3158–3163. URL: ://WOS:000227510900005.://WOS:000227510900005
Min B., Yamane H., Hu-Li J., Paul W.E. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J. Immunol., 2005., Vol. 174., No. 10, pp. 6039–6044. URL: ://WOS:000228958900018.://WOS:000228958900018
Min B., Yamane H., Hu-Li J., Paul W.E. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J. Immunol., 2005., Vol. 174., No. 10, pp. 6039–6044. URL: ://WOS:000228958900018.://WOS:000228958900018
Surh C.D., Sprent J. Homeostasis of I and memory T cells. Immunity, 2008, Vol. 29, No. 6, pp. 848–862. URL: ISI>://WOS:000262012400006.ISI>://WOS:000262012400006
Surh C.D., Sprent J. Homeostasis of I and memory T cells. Immunity, 2008, Vol. 29, No. 6, pp. 848–862. URL: ISI>://WOS:000262012400006.ISI>://WOS:000262012400006
Goldrath A.W., Bevan M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8(+) T cells in lymphopenic hosts. Immunity, 1999,Vol. 11, No. 2, pp. 183–190. URL: ://WOS:000082383400007.://WOS:000082383400007
Goldrath A.W., Bevan M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8(+) T cells in lymphopenic hosts. Immunity, 1999,Vol. 11, No. 2, pp. 183–190. URL: ://WOS:000082383400007.://WOS:000082383400007
Martin B., Bourgeois C., Dautigny N., Lucas B. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4(+) T cells. Proc. Natl. Acad. Sci. USA, 2003, Vol. 100, No. 10, pp. 6021–6026. URL: ://WOS:000182939400082.://WOS:000182939400082
Martin B., Bourgeois C., Dautigny N., Lucas B. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4(+) T cells. Proc. Natl. Acad. Sci. USA, 2003, Vol. 100, No. 10, pp. 6021–6026. URL: ://WOS:000182939400082.://WOS:000182939400082
Takeda S., Rodewald H.R., Arakawa H., Bluethmann H., Shimizu T. MHC class II molecules are not required for survival of newly generated CD4+T cells, but affect their long-term life span. Immunity, 1996, Vol. 5, No. 3, pp. 217–228. URL: http://www.ncbi.nlm.nih.gov/pubmed/8808677.http://www.ncbi.nlm.nih.gov/pubmed/8808677
Takeda S., Rodewald H.R., Arakawa H., Bluethmann H., Shimizu T. MHC class II molecules are not required for survival of newly generated CD4+T cells, but affect their long-term life span. Immunity, 1996, Vol. 5, No. 3, pp. 217–228. URL: http://www.ncbi.nlm.nih.gov/pubmed/8808677.http://www.ncbi.nlm.nih.gov/pubmed/8808677
Tanchot C., Lemonnier F.A., Perarnau B., Freitas A.A., Rocha B. Differential requirements for survival and proliferation of CD8 I or memory T cells. Science, 1997, Vol. 276, No. 5321, pp. 2057–2062. URL: http://www.ncbi.nlm.nih.gov/pubmed/9197272.http://www.ncbi.nlm.nih.gov/pubmed/9197272
Tanchot C., Lemonnier F.A., Perarnau B., Freitas A.A., Rocha B. Differential requirements for survival and proliferation of CD8 I or memory T cells. Science, 1997, Vol. 276, No. 5321, pp. 2057–2062. URL: http://www.ncbi.nlm.nih.gov/pubmed/9197272.http://www.ncbi.nlm.nih.gov/pubmed/9197272
Fry T.J., Mackall C.L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol., 2005, Vol. 174, No. 11, pp. 6571–6576. URL: http://www.ncbi.nlm.nih.gov/pubmed/15905493.http://www.ncbi.nlm.nih.gov/pubmed/15905493
Fry T.J., Mackall C.L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol., 2005, Vol. 174, No. 11, pp. 6571–6576. URL: http://www.ncbi.nlm.nih.gov/pubmed/15905493.http://www.ncbi.nlm.nih.gov/pubmed/15905493
Tan J.T., Dudl E., LeRoy E., Murray R., Sprent J., Weinberg K.I., Surh C.D. IL-7 is critical for homeostatic proliferation and survival of I T cells. Proc. Natl. Acad. Sci. USA, 2001, Vol. 98, No. 15, pp. 8732–8737. URL: ://WOS:000169967000094.://WOS:000169967000094
Tan J.T., Dudl E., LeRoy E., Murray R., Sprent J., Weinberg K.I., Surh C.D. IL-7 is critical for homeostatic proliferation and survival of I T cells. Proc. Natl. Acad. Sci. USA, 2001, Vol. 98, No. 15, pp. 8732–8737. URL: ://WOS:000169967000094.://WOS:000169967000094
Neujahr D.C., Chen C.Q., Huang X., Markmann J.F., Cobbold S., Waldmann H., Sayegh M.H., Hancock W.W., Turka L.A. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J. Immunol., 2006, Vol. 176, No. 8, pp. 4632–4639. URL: ISI>://WOS:000238769000020.ISI>://WOS:000238769000020
Neujahr D.C., Chen C.Q., Huang X., Markmann J.F., Cobbold S., Waldmann H., Sayegh M.H., Hancock W.W., Turka L.A. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J. Immunol., 2006, Vol. 176, No. 8, pp. 4632–4639. URL: ISI>://WOS:000238769000020.ISI>://WOS:000238769000020
Chalasani G., Dai Z.H., Konieczny B.T., Baddoura F.K., Lakkis F.G. Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. Proc. Natl. Acad. Sci. USA, 2002, Vol. 99, No. 9, pp. 6175–6180. URL: ://WOS:000175377800078.://WOS:000175377800078
Chalasani G., Dai Z.H., Konieczny B.T., Baddoura F.K., Lakkis F.G. Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. Proc. Natl. Acad. Sci. USA, 2002, Vol. 99, No. 9, pp. 6175–6180. URL: ://WOS:000175377800078.://WOS:000175377800078
Murali-Krishna K., Lau L.L., Sambhara S., Lemonnier F., Altman J., Ahmed R. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science, 1999, Vol. 286, No. 5443, pp. 1377–1381. URL: ://WOS:000083675500048.://WOS:000083675500048
Murali-Krishna K., Lau L.L., Sambhara S., Lemonnier F., Altman J., Ahmed R. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science, 1999, Vol. 286, No. 5443, pp. 1377–1381. URL: ://WOS:000083675500048.://WOS:000083675500048
Swain S.L., Hu H., Huston G. Class II-independent generation of CD4 memory T cells from effectors. Science, 1999, Vol. 286, No. 5443, pp. 1381–1383. URL: http://www.ncbi.nlm.nih.gov/pubmed/10558997.http://www.ncbi.nlm.nih.gov/pubmed/10558997
Swain S.L., Hu H., Huston G. Class II-independent generation of CD4 memory T cells from effectors. Science, 1999, Vol. 286, No. 5443, pp. 1381–1383. URL: http://www.ncbi.nlm.nih.gov/pubmed/10558997.http://www.ncbi.nlm.nih.gov/pubmed/10558997
Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J. Exp. Med., 2002, Vol. 195, No. 12, pp. 1523–1532. URL: https://www.ncbi.nlm.nih.gov/pubmed/12070280.https://www.ncbi.nlm.nih.gov/pubmed/12070280
Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J. Exp. Med., 2002, Vol. 195, No. 12, pp. 1523–1532. URL: https://www.ncbi.nlm.nih.gov/pubmed/12070280.https://www.ncbi.nlm.nih.gov/pubmed/12070280
Judge A.D., Zhang X.H., Fujii H., Surh C.D., Sprent J. Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells. J. Exp. Med., 2002, Vol. 196, No. 7, pp. 935–946. URL: ://WOS:000178518100007.://WOS:000178518100007
Judge A.D., Zhang X.H., Fujii H., Surh C.D., Sprent J. Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells. J. Exp. Med., 2002, Vol. 196, No. 7, pp. 935–946. URL: ://WOS:000178518100007.://WOS:000178518100007
Mohan M., Kaushal D., Aye P.P., Alvarez X., Veazey R.S., Lackner A.A. Focused Examination of the Intestinal Epithelium Reveals Transcriptional Signatures Consistent with Disturbances in Enterocyte Maturation and Differentiation during the Course of SIV Infection. PloS One, 2013, Vol. 8, pp. e60122. URL: ://WOS:000317909600013.://WOS:000317909600013
Mohan M., Kaushal D., Aye P.P., Alvarez X., Veazey R.S., Lackner A.A. Focused Examination of the Intestinal Epithelium Reveals Transcriptional Signatures Consistent with Disturbances in Enterocyte Maturation and Differentiation during the Course of SIV Infection. PloS One, 2013, Vol. 8, pp. e60122. URL: ://WOS:000317909600013.://WOS:000317909600013
Sharpstone D., Neild P., Crane R., Taylor C., Hodgson C., Sherwood R., Gazzard B., Bjarnason I. Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea. Gut, 1999, Vol. 45, No. 1, pp. 70–76. URL: ://WOS:000081079400016.://WOS:000081079400016
Sharpstone D., Neild P., Crane R., Taylor C., Hodgson C., Sherwood R., Gazzard B., Bjarnason I. Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea. Gut, 1999, Vol. 45, No. 1, pp. 70–76. URL: ://WOS:000081079400016.://WOS:000081079400016
Klatt N.R., Funderburg N.T., Brenchley J.M. Microbial translocation, immune activation, and HIV disease. Trends Microbiol., 2013, Vol. 21, No. 1, pp. 6–13. URL: http://www.ncbi.nlm.nih.gov/pubmed/23062765.http://www.ncbi.nlm.nih.gov/pubmed/23062765
Klatt N.R., Funderburg N.T., Brenchley J.M. Microbial translocation, immune activation, and HIV disease. Trends Microbiol., 2013, Vol. 21, No. 1, pp. 6–13. URL: http://www.ncbi.nlm.nih.gov/pubmed/23062765.http://www.ncbi.nlm.nih.gov/pubmed/23062765
Nazli A., Chan O., Dobson-Belaire W.N., Ouellet M., Tremblay M.J., Gray-Owen S.D., Arsenault A.L., Kaushic C. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PloS Pathog., 2010, Vol. 6, pp. e1000852. URL: ISI>://WOS:000277722400024.ISI>://WOS:000277722400024
Nazli A., Chan O., Dobson-Belaire W.N., Ouellet M., Tremblay M.J., Gray-Owen S.D., Arsenault A.L., Kaushic C. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PloS Pathog., 2010, Vol. 6, pp. e1000852. URL: ISI>://WOS:000277722400024.ISI>://WOS:000277722400024
Smith A.J., Schacker T.W., Reilly C.S., Haase A.T. A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. JAIDS, 2010, Vol. 55, No. 3, pp. 306–315. URL: ://WOS:000283847400006.://WOS:000283847400006
Smith A.J., Schacker T.W., Reilly C.S., Haase A.T. A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. JAIDS, 2010, Vol. 55, No. 3, pp. 306–315. URL: ://WOS:000283847400006.://WOS:000283847400006
Gordon S.N., Cervasi B., Odorizzi P., Silverman R., Aberra F., Ginsberg G., Estes J.D., Paiardini M., Frank I., Silvestri G. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. J. Immunol., 2010, Vol. 185, No. 9, pp. 5169–5179. URL: http://www.ncbi.nlm.nih.gov/pubmed/20889546.http://www.ncbi.nlm.nih.gov/pubmed/20889546
Gordon S.N., Cervasi B., Odorizzi P., Silverman R., Aberra F., Ginsberg G., Estes J.D., Paiardini M., Frank I., Silvestri G. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. J. Immunol., 2010, Vol. 185, No. 9, pp. 5169–5179. URL: http://www.ncbi.nlm.nih.gov/pubmed/20889546.http://www.ncbi.nlm.nih.gov/pubmed/20889546
Klatt N.R., Estes J.D., Sun X., Ortiz A.M., Barber J.S., Harris L.D., Cervasi B., Yokomizo L.K., Pan L., Vinton C.L., Tabb B., Canary L.A., Dang Q., Hirsch V.M., Alter G., Belkaid Y., Lifson J.D., Silvestri G., Milner J.D., Paiardini M., Haddad E.K., Brenchley J.M. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol., 2012, Vol. 5, No. 6, pp. 646–657. URL: ://WOS:000310572800007.://WOS:000310572800007
Klatt N.R., Estes J.D., Sun X., Ortiz A.M., Barber J.S., Harris L.D., Cervasi B., Yokomizo L.K., Pan L., Vinton C.L., Tabb B., Canary L.A., Dang Q., Hirsch V.M., Alter G., Belkaid Y., Lifson J.D., Silvestri G., Milner J.D., Paiardini M., Haddad E.K., Brenchley J.M. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol., 2012, Vol. 5, No. 6, pp. 646–657. URL: ://WOS:000310572800007.://WOS:000310572800007
Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., Kazzaz Z., Bornstein E., Lambotte O., Altmann D., Blazar B.R., Rodriguez B., Teixeira-Johnson L., Landay A., Martin J.N., Hecht F.M., Picker L.J., Lederman M.M., Deeks S.G., Douek D.C. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med., 2006, Vol. 12, No. 12, pp. 1365–1371. URL: http://www.ncbi.nlm.nih.gov/pubmed/17115046.http://www.ncbi.nlm.nih.gov/pubmed/17115046
Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., Kazzaz Z., Bornstein E., Lambotte O., Altmann D., Blazar B.R., Rodriguez B., Teixeira-Johnson L., Landay A., Martin J.N., Hecht F.M., Picker L.J., Lederman M.M., Deeks S.G., Douek D.C. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med., 2006, Vol. 12, No. 12, pp. 1365–1371. URL: http://www.ncbi.nlm.nih.gov/pubmed/17115046.http://www.ncbi.nlm.nih.gov/pubmed/17115046
Estes J.D., Harris L.D., Klatt N.R., Tabb B., Pittaluga S., Paiardini M., Barclay G.R., Smedley J., Pung R., Oliveira K.M., Hirsch V.M., Silvestri G., Douek D.C., Miller C.J., Haase A.T., Lifson J., Brenchley J.M. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PloS Pathog., 2010, Vol. 6, pp. e1001052. URL: ISI>://WOS:000281399900025.ISI>://WOS:000281399900025
Estes J.D., Harris L.D., Klatt N.R., Tabb B., Pittaluga S., Paiardini M., Barclay G.R., Smedley J., Pung R., Oliveira K.M., Hirsch V.M., Silvestri G., Douek D.C., Miller C.J., Haase A.T., Lifson J., Brenchley J.M. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PloS Pathog., 2010, Vol. 6, pp. e1001052. URL: ISI>://WOS:000281399900025.ISI>://WOS:000281399900025
Marchetti G., Bellistri G.M., Borghi E., Tincati C., Ferramosca S., La Francesca M., Morace G., Gori A., Monforte A.D. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. AIDS, 2008, Vol. 22, No. 15, pp. 2035–2038. URL: ://WOS:000259680100016.://WOS:000259680100016
Marchetti G., Bellistri G.M., Borghi E., Tincati C., Ferramosca S., La Francesca M., Morace G., Gori A., Monforte A.D. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. AIDS, 2008, Vol. 22, No. 15, pp. 2035–2038. URL: ://WOS:000259680100016.://WOS:000259680100016
Leon A., Leal L., Torres B., Lucero C., Inciarte A., Arnedo M., Plana M., Vila J., Gatell J.M., Garcia F. Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients. AIDS, 2015, Vol. 29, No. 6, pp. 675–681. URL: ISI>://WOS:000351688200005.ISI>://WOS:000351688200005
Leon A., Leal L., Torres B., Lucero C., Inciarte A., Arnedo M., Plana M., Vila J., Gatell J.M., Garcia F. Association of microbial translocation biomarkers with clinical outcome in controllers HIV-infected patients. AIDS, 2015, Vol. 29, No. 6, pp. 675–681. URL: ISI>://WOS:000351688200005.ISI>://WOS:000351688200005
Marchetti G., Cozzi-Lepri A., Merlini E., Bellistri G.M., Castagna A., Galli M., Verucchi G., Antinori A., Costantini A., Giacometti A., di Caro A., Monforte A.D., Grp I.F.S. Microbial translocation predicts disease progression of HIV-infected antiretroviral-I patients with high CD4(+) cell count. AIDS, 2011, Vol. 25, No. 11, pp. 1385–1394. URL: ://WOS:000292183900006.://WOS:000292183900006
Marchetti G., Cozzi-Lepri A., Merlini E., Bellistri G.M., Castagna A., Galli M., Verucchi G., Antinori A., Costantini A., Giacometti A., di Caro A., Monforte A.D., Grp I.F.S. Microbial translocation predicts disease progression of HIV-infected antiretroviral-I patients with high CD4(+) cell count. AIDS, 2011, Vol. 25, No. 11, pp. 1385–1394. URL: ://WOS:000292183900006.://WOS:000292183900006
Sandler N.G., Wand H., Roque A., Law M., Nason M.C., Nixon D.E., Pedersen C., Ruxrungtham K., Lewin S.R., Emery S., Neaton J.D., Brenchley J.M., Deeks S.G., Sereti I., Douek D.C., Grp I.S.S. Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection. J. Infect. Dis., 2011, Vol. 203, No. 6, pp. 780–790. URL: ://WOS:000287742700006.://WOS:000287742700006
Sandler N.G., Wand H., Roque A., Law M., Nason M.C., Nixon D.E., Pedersen C., Ruxrungtham K., Lewin S.R., Emery S., Neaton J.D., Brenchley J.M., Deeks S.G., Sereti I., Douek D.C., Grp I.S.S. Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection. J. Infect. Dis., 2011, Vol. 203, No. 6, pp. 780–790. URL: ://WOS:000287742700006.://WOS:000287742700006
Guihot A., Bourgarit A., Carcelain G., Autran B. Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus. Trends Immunol., 2011, Vol. 32, No. 3, pp. 131–137. URL: http://www.ncbi.nlm.nih.gov/pubmed/21317040.http://www.ncbi.nlm.nih.gov/pubmed/21317040
Guihot A., Bourgarit A., Carcelain G., Autran B. Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus. Trends Immunol., 2011, Vol. 32, No. 3, pp. 131–137. URL: http://www.ncbi.nlm.nih.gov/pubmed/21317040.http://www.ncbi.nlm.nih.gov/pubmed/21317040
Rallon N., Sempere-Ortells J.M., Soriano V., Benito J.M. Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia. J. Antimicrob. Chemother., 2013, Vol. 68, No. 11, pp. 2616–2625. URL: http://www.ncbi.nlm.nih.gov/pubmed/23833186.http://www.ncbi.nlm.nih.gov/pubmed/23833186
Rallon N., Sempere-Ortells J.M., Soriano V., Benito J.M. Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia. J. Antimicrob. Chemother., 2013, Vol. 68, No. 11, pp. 2616–2625. URL: http://www.ncbi.nlm.nih.gov/pubmed/23833186.http://www.ncbi.nlm.nih.gov/pubmed/23833186
Robbins G.K., Spritzler J.G., Chan E.S., Asmuth D.M., Gandhi R.T., Rodriguez B.A., Skowron G., Skolnik P.R., Shafer R.W., Pollard R.B., Team A.C.T.G. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin. Infect. Dis., 2009, Vol. 48, No. 3, pp. 350–361. URL: http://www.ncbi.nlm.nih.gov/pubmed/19123865.http://www.ncbi.nlm.nih.gov/pubmed/19123865
Robbins G.K., Spritzler J.G., Chan E.S., Asmuth D.M., Gandhi R.T., Rodriguez B.A., Skowron G., Skolnik P.R., Shafer R.W., Pollard R.B., Team A.C.T.G. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin. Infect. Dis., 2009, Vol. 48, No. 3, pp. 350–361. URL: http://www.ncbi.nlm.nih.gov/pubmed/19123865.http://www.ncbi.nlm.nih.gov/pubmed/19123865
Hua W., Jiao Y., Zhang H., Zhang T., Chen D., Zhang Y., Chen X., Wu H. Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment. Immunol. Invest., 2012, Vol. 41, No. 1, pp. 1–14. URL: http://www.ncbi.nlm.nih.gov/pubmed/21563924.http://www.ncbi.nlm.nih.gov/pubmed/21563924
Hua W., Jiao Y., Zhang H., Zhang T., Chen D., Zhang Y., Chen X., Wu H. Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment. Immunol. Invest., 2012, Vol. 41, No. 1, pp. 1–14. URL: http://www.ncbi.nlm.nih.gov/pubmed/21563924.http://www.ncbi.nlm.nih.gov/pubmed/21563924
Letvin N.L., Mascola J.R., Sun Y., Gorgone D.A., Buzby A.P., Xu L., Yang Z.Y., Chakrabarti B., Rao S.S., Schmitz J.E., Montefiori D.C., Barker B.R., Bookstein F.L., Nabel G.J. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science, 2006, Vol. 312, No. 5779, pp. 1530–1533. URL: http://www.ncbi.nlm.nih.gov/pubmed/16763152.http://www.ncbi.nlm.nih.gov/pubmed/16763152
Letvin N.L., Mascola J.R., Sun Y., Gorgone D.A., Buzby A.P., Xu L., Yang Z.Y., Chakrabarti B., Rao S.S., Schmitz J.E., Montefiori D.C., Barker B.R., Bookstein F.L., Nabel G.J. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science, 2006, Vol. 312, No. 5779, pp. 1530–1533. URL: http://www.ncbi.nlm.nih.gov/pubmed/16763152.http://www.ncbi.nlm.nih.gov/pubmed/16763152
Potter S.J., Lacabaratz C., Lambotte O., Perez-Patrigeon S., Vingert B., Sinet M., Colle J.H., Urrutia A., Scott-Algara D., Boufassa F., Delfraissy J.F., Theze J., Venet A., Chakrabarti L.A. Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J. Virol., 2007, Vol. 81, No. 24, pp. 13904–13915. URL: http://www.ncbi.nlm.nih.gov/pubmed/17928341.http://www.ncbi.nlm.nih.gov/pubmed/17928341
Potter S.J., Lacabaratz C., Lambotte O., Perez-Patrigeon S., Vingert B., Sinet M., Colle J.H., Urrutia A., Scott-Algara D., Boufassa F., Delfraissy J.F., Theze J., Venet A., Chakrabarti L.A. Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J. Virol., 2007, Vol. 81, No. 24, pp. 13904–13915. URL: http://www.ncbi.nlm.nih.gov/pubmed/17928341.http://www.ncbi.nlm.nih.gov/pubmed/17928341
Saidakova E.V., Shmagel K.V., Korolevskaya L.B., Shmage N.G., Chereshnev V.A. Lymphopenia-induced proliferation of CD4 T-cells is associated with CD4 T-lymphocyte exhaustion in treated HIV-infected patients. Indian J. Med. Res., 2018, Vol. 147, No. 4, pp. 376–383. URL: https://www.ncbi.nlm.nih.gov/pubmed/29998873.https://www.ncbi.nlm.nih.gov/pubmed/29998873
Saidakova E.V., Shmagel K.V., Korolevskaya L.B., Shmage N.G., Chereshnev V.A. Lymphopenia-induced proliferation of CD4 T-cells is associated with CD4 T-lymphocyte exhaustion in treated HIV-infected patients. Indian J. Med. Res., 2018, Vol. 147, No. 4, pp. 376–383. URL: https://www.ncbi.nlm.nih.gov/pubmed/29998873.https://www.ncbi.nlm.nih.gov/pubmed/29998873
Autran B., Carcelaint G., Li T.S., Gorochov G., Blanc C., Renaud M., Durali M., Mathez D., Calvez V., Leibowitch J., Katlama C., Debre P. Restoration of the immune system with anti-retroviral therapy. Immunol. Lett., 1999, Vol. 66, No. 1–3, pp. 207–211. URL: ISI>://WOS:000079258500031.ISI>://WOS:000079258500031
Autran B., Carcelaint G., Li T.S., Gorochov G., Blanc C., Renaud M., Durali M., Mathez D., Calvez V., Leibowitch J., Katlama C., Debre P. Restoration of the immune system with anti-retroviral therapy. Immunol. Lett., 1999, Vol. 66, No. 1–3, pp. 207–211. URL: ISI>://WOS:000079258500031.ISI>://WOS:000079258500031
Piketty C., Castiel P., Belec L., Batisse D., Si Mohamed A., Gilquin J., Gonzalez-Canali G., Jayle D., Karmochkine M., Weiss L., Aboulker J.P., Kazatchkine M.D. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS, 1998, Vol. 12, No. 7, pp. 745–750. URL: http://www.ncbi.nlm.nih.gov/pubmed/9619806.http://www.ncbi.nlm.nih.gov/pubmed/9619806
Piketty C., Castiel P., Belec L., Batisse D., Si Mohamed A., Gilquin J., Gonzalez-Canali G., Jayle D., Karmochkine M., Weiss L., Aboulker J.P., Kazatchkine M.D. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS, 1998, Vol. 12, No. 7, pp. 745–750. URL: http://www.ncbi.nlm.nih.gov/pubmed/9619806.http://www.ncbi.nlm.nih.gov/pubmed/9619806
Gaardbo J.C., Hartling H.J., Gerstoft J., Nielsen S.D. Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions. Clin. Dev. Immunol., 2012, Vol. 2012, pp. 670 957. URL: http://www.ncbi.nlm.nih.gov/pubmed/22474480.http://www.ncbi.nlm.nih.gov/pubmed/22474480
Gaardbo J.C., Hartling H.J., Gerstoft J., Nielsen S.D. Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions. Clin. Dev. Immunol., 2012, Vol. 2012, pp. 670 957. URL: http://www.ncbi.nlm.nih.gov/pubmed/22474480.http://www.ncbi.nlm.nih.gov/pubmed/22474480
Massanella M., Negredo E., Clotet B., Blanco J. Immunodiscordant responses to HAART — mechanisms and consequences. Expert Rev. Clin. Immunol., 2013, Vol. 9, No. 11, pp. 1135–1149. URL: http://www.ncbi.nlm.nih.gov/pubmed/24168417.http://www.ncbi.nlm.nih.gov/pubmed/24168417
Massanella M., Negredo E., Clotet B., Blanco J. Immunodiscordant responses to HAART — mechanisms and consequences. Expert Rev. Clin. Immunol., 2013, Vol. 9, No. 11, pp. 1135–1149. URL: http://www.ncbi.nlm.nih.gov/pubmed/24168417.http://www.ncbi.nlm.nih.gov/pubmed/24168417
Autran B., Carcelain G., Li T.S., Blanc C., Mathez D., Tubiana R., Katlama C., Debre P., Leibowitch J. Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. Science, 1997, Vol. 277, No. 5322, pp. 112–116. URL: ISI>://WOS:A1997XJ41800052.ISI>://WOS:A1997XJ41800052
Autran B., Carcelain G., Li T.S., Blanc C., Mathez D., Tubiana R., Katlama C., Debre P., Leibowitch J. Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. Science, 1997, Vol. 277, No. 5322, pp. 112–116. URL: ISI>://WOS:A1997XJ41800052.ISI>://WOS:A1997XJ41800052
Tuboi S.H., Pacheco A.G., Harrison L.H., Stone R.A., May M., Brinkhof M.W., Dabis F., Egger M., Nash D., Bangsberg D., Braitstein P., Yiannoutsos C.T., Wood R., Sprinz E., Schechter M., IeDEA A.o. Mortality associated with discordant responses to antiretroviral therapy in resource-constrained settings. JAIDS, 2010, Vol. 53, No. 1, pp. 70–77. URL: https://www.ncbi.nlm.nih.gov/pubmed/20035163.https://www.ncbi.nlm.nih.gov/pubmed/20035163
Tuboi S.H., Pacheco A.G., Harrison L.H., Stone R.A., May M., Brinkhof M.W., Dabis F., Egger M., Nash D., Bangsberg D., Braitstein P., Yiannoutsos C.T., Wood R., Sprinz E., Schechter M., IeDEA A.o. Mortality associated with discordant responses to antiretroviral therapy in resource-constrained settings. JAIDS, 2010, Vol. 53, No. 1, pp. 70–77. URL: https://www.ncbi.nlm.nih.gov/pubmed/20035163.https://www.ncbi.nlm.nih.gov/pubmed/20035163
Tan R., Westfall A.O., Willig J.H., Mugavero M.J., Saag M.S., Kaslow R.A., Kempf M.C. Clinical outcome of HIV-infected antiretroviral-I patients with discordant immunologic and virologic responses to highly active antiretroviral therapy. JAIDS, 2008, Vol. 47, No. 5, pp. 553–558. URL: http://www.ncbi.nlm.nih.gov/pubmed/18285713.http://www.ncbi.nlm.nih.gov/pubmed/18285713
Tan R., Westfall A.O., Willig J.H., Mugavero M.J., Saag M.S., Kaslow R.A., Kempf M.C. Clinical outcome of HIV-infected antiretroviral-I patients with discordant immunologic and virologic responses to highly active antiretroviral therapy. JAIDS, 2008, Vol. 47, No. 5, pp. 553–558. URL: http://www.ncbi.nlm.nih.gov/pubmed/18285713.http://www.ncbi.nlm.nih.gov/pubmed/18285713
Batista G., Buve A., Ngom Gueye N.F., Manga N.M., Diop M.N., Ndiaye K., Thiam A., Ly F., Diallo A., Ndour C.T., Seydi M. Initial suboptimal CD4 reconstitution with antiretroviral therapy despite full viral suppression in a cohort of HIV-infected patients in Senegal. Med. Mal. Infect., 2015, Vol. 45, No. 6, pp. 199–206. URL: https://www.ncbi.nlm.nih.gov/pubmed/25907261.https://www.ncbi.nlm.nih.gov/pubmed/25907261
Batista G., Buve A., Ngom Gueye N.F., Manga N.M., Diop M.N., Ndiaye K., Thiam A., Ly F., Diallo A., Ndour C.T., Seydi M. Initial suboptimal CD4 reconstitution with antiretroviral therapy despite full viral suppression in a cohort of HIV-infected patients in Senegal. Med. Mal. Infect., 2015, Vol. 45, No. 6, pp. 199–206. URL: https://www.ncbi.nlm.nih.gov/pubmed/25907261.https://www.ncbi.nlm.nih.gov/pubmed/25907261
Baker J.V., Peng G., Rapkin J., Krason D., Reilly C., Cavert W.P., Abrams D.I., MacArthur R.D., Henry K., Neaton J.D., Terry Beirn Community Programs for Clinical Research on A. Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases. JAIDS, 2008, Vol. 48, No. 5, pp. 541–546. URL: https://www.ncbi.nlm.nih.gov/pubmed/18645520.https://www.ncbi.nlm.nih.gov/pubmed/18645520
Baker J.V., Peng G., Rapkin J., Krason D., Reilly C., Cavert W.P., Abrams D.I., MacArthur R.D., Henry K., Neaton J.D., Terry Beirn Community Programs for Clinical Research on A. Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases. JAIDS, 2008, Vol. 48, No. 5, pp. 541–546. URL: https://www.ncbi.nlm.nih.gov/pubmed/18645520.https://www.ncbi.nlm.nih.gov/pubmed/18645520
Grabar S., Le Moing V., Goujard C., Leport C., Kazatchkine M.D., Costagliola D., Weiss L. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann. Intern. Med., 2000, Vol. 133, No. 6, pp. 401–410. URL: http://www.ncbi.nlm.nih.gov/pubmed/10975957.http://www.ncbi.nlm.nih.gov/pubmed/10975957
Grabar S., Le Moing V., Goujard C., Leport C., Kazatchkine M.D., Costagliola D., Weiss L. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann. Intern. Med., 2000, Vol. 133, No. 6, pp. 401–410. URL: http://www.ncbi.nlm.nih.gov/pubmed/10975957.http://www.ncbi.nlm.nih.gov/pubmed/10975957
Gutierrez F., Padilla S., Masia M., Iribarren J.A., Moreno S., Viciana P., Hernandez-Quero J., Aleman R., Vidal F., Salavert M., Blanco J.R., Leal M., Dronda F., Perez Hoyos S., del Amo J., Co R.M. Patients’ characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy. Curr. HIV Res., 2008, Vol. 6, No. 2, pp. 100–107. URL: https://www.ncbi.nlm.nih.gov/pubmed/18336257.https://www.ncbi.nlm.nih.gov/pubmed/18336257
Gutierrez F., Padilla S., Masia M., Iribarren J.A., Moreno S., Viciana P., Hernandez-Quero J., Aleman R., Vidal F., Salavert M., Blanco J.R., Leal M., Dronda F., Perez Hoyos S., del Amo J., Co R.M. Patients’ characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy. Curr. HIV Res., 2008, Vol. 6, No. 2, pp. 100–107. URL: https://www.ncbi.nlm.nih.gov/pubmed/18336257.https://www.ncbi.nlm.nih.gov/pubmed/18336257
Gilson R.J., Man S.L., Copas A., Rider A., Forsyth S., Hill T., Bansi L., Porter K., Gazzard B., Orkin C., Pillay D., Schwenk A., Johnson M., Easterbook P., Walsh J., Fisher M., Leen C., Anderson J., Sabin C.A., Group U.K.C.H.C.S. Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study. Hiv Med., 2010, Vol. 11, No. 2, pp. 152–160. URL: https://www.ncbi.nlm.nih.gov/pubmed/19732175.https://www.ncbi.nlm.nih.gov/pubmed/19732175
Gilson R.J., Man S.L., Copas A., Rider A., Forsyth S., Hill T., Bansi L., Porter K., Gazzard B., Orkin C., Pillay D., Schwenk A., Johnson M., Easterbook P., Walsh J., Fisher M., Leen C., Anderson J., Sabin C.A., Group U.K.C.H.C.S. Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study. Hiv Med., 2010, Vol. 11, No. 2, pp. 152–160. URL: https://www.ncbi.nlm.nih.gov/pubmed/19732175.https://www.ncbi.nlm.nih.gov/pubmed/19732175
Dronda F., Moreno S., Moreno A., Casado J.L., Perez-Elias M.J., Antela A. Long-term outcomes among antiretroviral-I human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppression. Clin. Infect. Dis., 2002, Vol. 35, No. 8, pp. 1005–1009. URL: https://www.ncbi.nlm.nih.gov/pubmed/12355389.https://www.ncbi.nlm.nih.gov/pubmed/12355389
Dronda F., Moreno S., Moreno A., Casado J.L., Perez-Elias M.J., Antela A. Long-term outcomes among antiretroviral-I human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppression. Clin. Infect. Dis., 2002, Vol. 35, No. 8, pp. 1005–1009. URL: https://www.ncbi.nlm.nih.gov/pubmed/12355389.https://www.ncbi.nlm.nih.gov/pubmed/12355389
Nakanjako D., Kiragga A., Ibrahim F., Castelnuovo B., Kamya M.R., Easterbrook P.J. Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on antiretroviral therapy (ART) in sub-Saharan Africa: frequency and clinical significance. AIDS Res. Ther., 2008, Vol. 5, pp. 23. URL: https://www.ncbi.nlm.nih.gov/pubmed/18957083.https://www.ncbi.nlm.nih.gov/pubmed/18957083
Nakanjako D., Kiragga A., Ibrahim F., Castelnuovo B., Kamya M.R., Easterbrook P.J. Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on antiretroviral therapy (ART) in sub-Saharan Africa: frequency and clinical significance. AIDS Res. Ther., 2008, Vol. 5, pp. 23. URL: https://www.ncbi.nlm.nih.gov/pubmed/18957083.https://www.ncbi.nlm.nih.gov/pubmed/18957083
Takuva S., Maskew M., Brennan A.T., Long L., Sanne I., Fox M.P. Poor CD4 recovery and risk of subsequent progression to AIDS or death despite viral suppression in a South African cohort. J. Int. AIDS Soc., 2014, Vol. 17, pp. 18 651. URL: https://www.ncbi.nlm.nih.gov/pubmed/24594114.https://www.ncbi.nlm.nih.gov/pubmed/24594114
Takuva S., Maskew M., Brennan A.T., Long L., Sanne I., Fox M.P. Poor CD4 recovery and risk of subsequent progression to AIDS or death despite viral suppression in a South African cohort. J. Int. AIDS Soc., 2014, Vol. 17, pp. 18 651. URL: https://www.ncbi.nlm.nih.gov/pubmed/24594114.https://www.ncbi.nlm.nih.gov/pubmed/24594114
Zoufaly A., an der Heiden M., Kollan C., Bogner J.R., Fatkenheuer G., Wasmuth J.C., Stoll M., Hamouda O., van Lunzen J., ClinSurv Study G. Clinical outcome of HIV-infected patients with discordant virological and immunological response to antiretroviral therapy. J. Infect. Dis., 2011, Vol. 203, No. 3, pp. 364–371. URL: https://www.ncbi.nlm.nih.gov/pubmed/21208929.https://www.ncbi.nlm.nih.gov/pubmed/21208929
Zoufaly A., an der Heiden M., Kollan C., Bogner J.R., Fatkenheuer G., Wasmuth J.C., Stoll M., Hamouda O., van Lunzen J., ClinSurv Study G. Clinical outcome of HIV-infected patients with discordant virological and immunological response to antiretroviral therapy. J. Infect. Dis., 2011, Vol. 203, No. 3, pp. 364–371. URL: https://www.ncbi.nlm.nih.gov/pubmed/21208929.https://www.ncbi.nlm.nih.gov/pubmed/21208929
Loutfy M.R., Genebat M., Moore D., Raboud J., Chan K., Antoniou T., Milan D., Shen A., Klein M.B., Cooper C., Machouf N., Rourke S.B., Rachlis A., Tsoukas C., Montaner J.S., Walmsley S.L., Smieja M., Bayoumi A., Mills E., Hogg R.S., Collaboration C. A CD4+ cell count <200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression. JAIDS, 2010, Vol. 55, No. 4, pp. 451–459. URL: https://www.ncbi.nlm.nih.gov/pubmed/21105259.https://www.ncbi.nlm.nih.gov/pubmed/21105259
Loutfy M.R., Genebat M., Moore D., Raboud J., Chan K., Antoniou T., Milan D., Shen A., Klein M.B., Cooper C., Machouf N., Rourke S.B., Rachlis A., Tsoukas C., Montaner J.S., Walmsley S.L., Smieja M., Bayoumi A., Mills E., Hogg R.S., Collaboration C. A CD4+ cell count <200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression. JAIDS, 2010, Vol. 55, No. 4, pp. 451–459. URL: https://www.ncbi.nlm.nih.gov/pubmed/21105259.https://www.ncbi.nlm.nih.gov/pubmed/21105259
Falster K., Petoumenos K., Chuah J., Mijch A., Mulhall B., Kelly M., Cooper D.A., Australian H.I.V.O.D. Poor baseline immune function predicts an incomplete immune response to combination antiretroviral treatment despite sustained viral suppression. JAIDS, 2009, Vol. 50, No. 3, pp. 307–313. URL: https://www.ncbi.nlm.nih.gov/pubmed/19194311.https://www.ncbi.nlm.nih.gov/pubmed/19194311
Falster K., Petoumenos K., Chuah J., Mijch A., Mulhall B., Kelly M., Cooper D.A., Australian H.I.V.O.D. Poor baseline immune function predicts an incomplete immune response to combination antiretroviral treatment despite sustained viral suppression. JAIDS, 2009, Vol. 50, No. 3, pp. 307–313. URL: https://www.ncbi.nlm.nih.gov/pubmed/19194311.https://www.ncbi.nlm.nih.gov/pubmed/19194311
Engsig F.N., Gerstoft J., Kronborg G., Larsen C.S., Pedersen G., Roge B., Jensen J., Nielsen L.N., Obel N. Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study. BMC Infect. Dis., 2010, Vol. 10, pp. 318. URL: http://www.ncbi.nlm.nih.gov/pubmed/21044307.http://www.ncbi.nlm.nih.gov/pubmed/21044307
Engsig F.N., Gerstoft J., Kronborg G., Larsen C.S., Pedersen G., Roge B., Jensen J., Nielsen L.N., Obel N. Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study. BMC Infect. Dis., 2010, Vol. 10, pp. 318. URL: http://www.ncbi.nlm.nih.gov/pubmed/21044307.http://www.ncbi.nlm.nih.gov/pubmed/21044307
Kaufmann G.R., Furrer H., Ledergerber B., Perrin L., Opravil M., Vernazza P., Cavassini M., Bernasconi E., Rickenbach M., Hirschel B., Battegay M., Swiss H.I.V.C.S. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to Clin. Infect. Dis., 2005, Vol. 41, No. 3, pp. 361–372. URL: https://www.ncbi.nlm.nih.gov/pubmed/16007534.https://www.ncbi.nlm.nih.gov/pubmed/16007534
Kaufmann G.R., Furrer H., Ledergerber B., Perrin L., Opravil M., Vernazza P., Cavassini M., Bernasconi E., Rickenbach M., Hirschel B., Battegay M., Swiss H.I.V.C.S. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to Clin. Infect. Dis., 2005, Vol. 41, No. 3, pp. 361–372. URL: https://www.ncbi.nlm.nih.gov/pubmed/16007534.https://www.ncbi.nlm.nih.gov/pubmed/16007534
De Maria A., Cossarizza A. CD4saurus Rex &HIVelociraptor vs. development of clinically useful immunological markers: a Jurassic tale of frozen evolution. J. Transl. Med., 2011, Vol. 9, pp. 93. URL: https://www.ncbi.nlm.nih.gov/pubmed/21679413.https://www.ncbi.nlm.nih.gov/pubmed/21679413
De Maria A., Cossarizza A. CD4saurus Rex &HIVelociraptor vs. development of clinically useful immunological markers: a Jurassic tale of frozen evolution. J. Transl. Med., 2011, Vol. 9, pp. 93. URL: https://www.ncbi.nlm.nih.gov/pubmed/21679413.https://www.ncbi.nlm.nih.gov/pubmed/21679413
Engsig F.N., Zangerle R., Katsarou O., Dabis F., Reiss P., Gill J., Porter K., Sabin C., Riordan A., Fatkenheuer G., Gutierrez F., Raffi F., Kirk O., Mary-Krause M., Stephan C., de Olalla P.G., Guest J., Samji H., Castagna A., d’Arminio Monforte A., Skaletz-Rorowski A., Ramos J., Lapadula G., Mussini C., Force L., Meyer L., Lampe F., Boufassa F., Bucher H.C., De Wit S., Burkholder G.A., Teira R., Justice A.C., Sterling T.R., H M.C., Gerstoft J., Grarup J., May M., Chene G., Ingle S.M., Sterne J., Obel N., Antiretroviral Therapy Cohort C., the Collaboration of Observational H.I.V.E.R.E.i.E. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin. Infect. Dis., 2014, Vol. 58, No. 9, pp. 1312–1321. URL: https://www.ncbi.nlm.nih.gov/pubmed/24457342.https://www.ncbi.nlm.nih.gov/pubmed/24457342
Engsig F.N., Zangerle R., Katsarou O., Dabis F., Reiss P., Gill J., Porter K., Sabin C., Riordan A., Fatkenheuer G., Gutierrez F., Raffi F., Kirk O., Mary-Krause M., Stephan C., de Olalla P.G., Guest J., Samji H., Castagna A., d’Arminio Monforte A., Skaletz-Rorowski A., Ramos J., Lapadula G., Mussini C., Force L., Meyer L., Lampe F., Boufassa F., Bucher H.C., De Wit S., Burkholder G.A., Teira R., Justice A.C., Sterling T.R., H M.C., Gerstoft J., Grarup J., May M., Chene G., Ingle S.M., Sterne J., Obel N., Antiretroviral Therapy Cohort C., the Collaboration of Observational H.I.V.E.R.E.i.E. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin. Infect. Dis., 2014, Vol. 58, No. 9, pp. 1312–1321. URL: https://www.ncbi.nlm.nih.gov/pubmed/24457342.https://www.ncbi.nlm.nih.gov/pubmed/24457342
Kelley C.F., Kitchen C.M., Hunt P.W., Rodriguez B., Hecht F.M., Kitahata M., Crane H.M., Willig J., Mugavero M., Saag M., Martin J.N., Deeks S.G. Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin. Infect. Dis., 2009, Vol. 48, No. 6, pp. 787–794. URL: https://www.ncbi.nlm.nih.gov/pubmed/19193107.https://www.ncbi.nlm.nih.gov/pubmed/19193107
Kelley C.F., Kitchen C.M., Hunt P.W., Rodriguez B., Hecht F.M., Kitahata M., Crane H.M., Willig J., Mugavero M., Saag M., Martin J.N., Deeks S.G. Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin. Infect. Dis., 2009, Vol. 48, No. 6, pp. 787–794. URL: https://www.ncbi.nlm.nih.gov/pubmed/19193107.https://www.ncbi.nlm.nih.gov/pubmed/19193107
Kaufmann G.R., Perrin L., Pantaleo G., Opravil M., Furrer H., Telenti A., Hirschel B., Ledergerber B., Vernazza P., Bernasconi E., Rickenbach M., Egger M., Battegay M., Swiss H.I.V.C.S.G. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study. Arch. Intern. Med., 2003, Vol. 163, No. 18, pp. 2187–2195. URL: http://www.ncbi.nlm.nih.gov/pubmed/14557216.http://www.ncbi.nlm.nih.gov/pubmed/14557216
Kaufmann G.R., Perrin L., Pantaleo G., Opravil M., Furrer H., Telenti A., Hirschel B., Ledergerber B., Vernazza P., Bernasconi E., Rickenbach M., Egger M., Battegay M., Swiss H.I.V.C.S.G. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study. Arch. Intern. Med., 2003, Vol. 163, No. 18, pp. 2187–2195. URL: http://www.ncbi.nlm.nih.gov/pubmed/14557216.http://www.ncbi.nlm.nih.gov/pubmed/14557216
Шмагель Н.Г., Шмагель К.В., Черешнев В.А. Клинические аспекты неэффективности высокоактивной антиретровирусной терапии // Инфекционные болезни. 2011. Т. 9, № 1. С. 5–10.
Meyaard L., Otto S.A., Jonker R.R., Mijnster M.J., Keet R.P.M., Miedema F. Programmed death of T-cells in HIV-1 infection. Science, 1992, Vol. 257, No. 5067, pp. 217–219. URL: ://WOS:A1992JC58500030.://WOS:A1992JC58500030
Meyaard L., Otto S.A., Jonker R.R., Mijnster M.J., Keet R.P.M., Miedema F. Programmed death of T-cells in HIV-1 infection. Science, 1992, Vol. 257, No. 5067, pp. 217–219. URL: ://WOS:A1992JC58500030.://WOS:A1992JC58500030
Li Q.S., Duan L.J., Estes J.D., Ma Z.M., Rourke T., Wang Y.C., Reilly C., Carlis J., Miller C.J., Haase A.T. Peak SIV replication in resting memory CD4(+) T cells depletes gut lamina propria CD4(+) T cells. Nature, 2005, Vol. 434, No. 7037, pp. 1148–1152. URL: ISI>://WOS:000228693300047.ISI>://WOS:000228693300047
Li Q.S., Duan L.J., Estes J.D., Ma Z.M., Rourke T., Wang Y.C., Reilly C., Carlis J., Miller C.J., Haase A.T. Peak SIV replication in resting memory CD4(+) T cells depletes gut lamina propria CD4(+) T cells. Nature, 2005, Vol. 434, No. 7037, pp. 1148–1152. URL: ISI>://WOS:000228693300047.ISI>://WOS:000228693300047
Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., Roederer M. Massive infection and loss of memory CD4(+) T cells in multiple tissues during acute SIV infection. Nature, 2005, Vol. 434, No. 7037, pp. 1093–1097. URL: ://WOS:000228693300033.://WOS:000228693300033
Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., Roederer M. Massive infection and loss of memory CD4(+) T cells in multiple tissues during acute SIV infection. Nature, 2005, Vol. 434, No. 7037, pp. 1093–1097. URL: ://WOS:000228693300033.://WOS:000228693300033
Picker L.J., Hagen S.I., Lum R., Reed-Inderbitzin E.F., Daly L.M., Sylwester A.W., Walker J.M., Siess D.C., Piatak M., Wang C.X., Allison D.B., Maino V.C., Lifson J.D., Kodama T., Axthelm M.K. Insufficient production and tissue delivery of CD4(+) memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med., 2004, Vol. 200, No. 10, pp. 1299–1314. URL: ISI>://WOS:000225404300008.ISI>://WOS:000225404300008
Picker L.J., Hagen S.I., Lum R., Reed-Inderbitzin E.F., Daly L.M., Sylwester A.W., Walker J.M., Siess D.C., Piatak M., Wang C.X., Allison D.B., Maino V.C., Lifson J.D., Kodama T., Axthelm M.K. Insufficient production and tissue delivery of CD4(+) memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med., 2004, Vol. 200, No. 10, pp. 1299–1314. URL: ISI>://WOS:000225404300008.ISI>://WOS:000225404300008
Mosier D.E., Gulizia R.J., Macisaac P.D., Torbett B.E., Levy J.A. Rapid loss of CD4+ T-cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science, 1993, Vol. 260, No. 5108, pp. 689–692. URL: ://WOS:A1993KZ64100037.://WOS:A1993KZ64100037
Mosier D.E., Gulizia R.J., Macisaac P.D., Torbett B.E., Levy J.A. Rapid loss of CD4+ T-cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science, 1993, Vol. 260, No. 5108, pp. 689–692. URL: ://WOS:A1993KZ64100037.://WOS:A1993KZ64100037
Finkel T.H., Tudorwilliams G., Banda N.K., Cotton M.F., Curiel T., Monks C., Baba T.W., Ruprecht R.M., Kupfer A. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-infected and SIV-infected lymph nodes. Nat. Med., 1995, Vol. 1, No. 2, pp. 129–134. URL: ://WOS:A1995QX55800022.://WOS:A1995QX55800022
Finkel T.H., Tudorwilliams G., Banda N.K., Cotton M.F., Curiel T., Monks C., Baba T.W., Ruprecht R.M., Kupfer A. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV-infected and SIV-infected lymph nodes. Nat. Med., 1995, Vol. 1, No. 2, pp. 129–134. URL: ://WOS:A1995QX55800022.://WOS:A1995QX55800022
Giorgi J.V., Hultin L.E., McKeating J.A., Johnson T.D., Owens B., Jacobson L.P., Shih R., Lewis J., Wiley D.J., Phair J.P., Wolinsky S.M., Detels R. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis., 1999, Vol. 179, No. 4, pp. 859–870. URL: ISI>://WOS:000079503800013.ISI>://WOS:000079503800013
Giorgi J.V., Hultin L.E., McKeating J.A., Johnson T.D., Owens B., Jacobson L.P., Shih R., Lewis J., Wiley D.J., Phair J.P., Wolinsky S.M., Detels R. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis., 1999, Vol. 179, No. 4, pp. 859–870. URL: ISI>://WOS:000079503800013.ISI>://WOS:000079503800013
Zangerle R., Steinhuber S., Sarcletti M., Dierich M.P., Wachter H., Fuchs D., Most J. Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals. Int. Arch. Allergy Imm., 1998, Vol. 116, No. 3, pp. 228–239. URL: ://WOS:000074827700008.://WOS:000074827700008
Zangerle R., Steinhuber S., Sarcletti M., Dierich M.P., Wachter H., Fuchs D., Most J. Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals. Int. Arch. Allergy Imm., 1998, Vol. 116, No. 3, pp. 228–239. URL: ://WOS:000074827700008.://WOS:000074827700008
Deeks S.G., Kitchen C.M., Liu L., Guo H., Gascon R., Narvaez A.B., Hunt P., Martin J.N., Kahn J.O., Levy J., McGrath M.S., Hecht F.M. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood, 2004, Vol. 104, No. 4, pp. 942–947. URL: http://www.ncbi.nlm.nih.gov/pubmed/15117761.http://www.ncbi.nlm.nih.gov/pubmed/15117761
Deeks S.G., Kitchen C.M., Liu L., Guo H., Gascon R., Narvaez A.B., Hunt P., Martin J.N., Kahn J.O., Levy J., McGrath M.S., Hecht F.M. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood, 2004, Vol. 104, No. 4, pp. 942–947. URL: http://www.ncbi.nlm.nih.gov/pubmed/15117761.http://www.ncbi.nlm.nih.gov/pubmed/15117761
Hazenberg M.D., Otto S.A., van Benthem B.H., Roos M.T., Coutinho R.A., Lange J.M., Hamann D., Prins M., Miedema F. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS, 2003, Vol. 17, No. 13, pp. 1881–1888. URL: http://www.ncbi.nlm.nih.gov/pubmed/12960820.http://www.ncbi.nlm.nih.gov/pubmed/12960820
Hazenberg M.D., Otto S.A., van Benthem B.H., Roos M.T., Coutinho R.A., Lange J.M., Hamann D., Prins M., Miedema F. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS, 2003, Vol. 17, No. 13, pp. 1881–1888. URL: http://www.ncbi.nlm.nih.gov/pubmed/12960820.http://www.ncbi.nlm.nih.gov/pubmed/12960820
Liu Z., Cumberland W.G., Hultin L.E., Kaplan A.H., Detels R., Giorgi J.V. CD8(+) T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J. Acq. Immun. Def. Syndr., 1998, Vol. 18, No. 4, pp. 332–340. URL: ISI>://WOS:000075124600004.ISI>://WOS:000075124600004
Liu Z., Cumberland W.G., Hultin L.E., Kaplan A.H., Detels R., Giorgi J.V. CD8(+) T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J. Acq. Immun. Def. Syndr., 1998, Vol. 18, No. 4, pp. 332–340. URL: ISI>://WOS:000075124600004.ISI>://WOS:000075124600004
Lackner A.A., Lederman M.M., Rodriguez B. HIV pathogenesis: the host. Cold Spring Harb Perspect Med., 2012, Vol. 2, pp. a007005. URL: http://www.ncbi.nlm.nih.gov/pubmed/22951442.http://www.ncbi.nlm.nih.gov/pubmed/22951442
Lackner A.A., Lederman M.M., Rodriguez B. HIV pathogenesis: the host. Cold Spring Harb Perspect Med., 2012, Vol. 2, pp. a007005. URL: http://www.ncbi.nlm.nih.gov/pubmed/22951442.http://www.ncbi.nlm.nih.gov/pubmed/22951442
Paiardini M., Muller-Trutwin M. HIV-associated chronic immune activation. Immunol. Rev., 2013, Vol. 254, pp. 78–101. URL: ISI>://WOS:000320390900006.ISI>://WOS:000320390900006
Paiardini M., Muller-Trutwin M. HIV-associated chronic immune activation. Immunol. Rev., 2013, Vol. 254, pp. 78–101. URL: ISI>://WOS:000320390900006.ISI>://WOS:000320390900006
Budd R.C. Activation-induced cell death. Curr. Opin. Immunol., 2001, Vol. 13, No. 3, pp. 356–362. URL: http://www.ncbi.nlm.nih.gov/pubmed/11406369.http://www.ncbi.nlm.nih.gov/pubmed/11406369
Budd R.C. Activation-induced cell death. Curr. Opin. Immunol., 2001, Vol. 13, No. 3, pp. 356–362. URL: http://www.ncbi.nlm.nih.gov/pubmed/11406369.http://www.ncbi.nlm.nih.gov/pubmed/11406369
Green D.R., Droin N., Pinkoski M. Activation-induced cell death in T cells. Immunol. Rev., 2003, Vol. 193, pp. 70–81. URL: http://www.ncbi.nlm.nih.gov/pubmed/12752672.http://www.ncbi.nlm.nih.gov/pubmed/12752672
Green D.R., Droin N., Pinkoski M. Activation-induced cell death in T cells. Immunol. Rev., 2003, Vol. 193, pp. 70–81. URL: http://www.ncbi.nlm.nih.gov/pubmed/12752672.http://www.ncbi.nlm.nih.gov/pubmed/12752672
Brenner D., Krammer P.H., Arnold R. Concepts of activated T cell death. Crit. Rev. Oncol. Hematol., 2008, Vol. 66, No. 1, pp. 52–64. URL: http://www.ncbi.nlm.nih.gov/pubmed/18289867.http://www.ncbi.nlm.nih.gov/pubmed/18289867
Brenner D., Krammer P.H., Arnold R. Concepts of activated T cell death. Crit. Rev. Oncol. Hematol., 2008, Vol. 66, No. 1, pp. 52–64. URL: http://www.ncbi.nlm.nih.gov/pubmed/18289867.http://www.ncbi.nlm.nih.gov/pubmed/18289867
Funderburg N., Luciano A.A., Jiang W., Rodriguez B., Sieg S.F., Lederman M.M. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One, 2008, Vol. 3, pp. e1915. URL: http://www.ncbi.nlm.nih.gov/pubmed/18382686.http://www.ncbi.nlm.nih.gov/pubmed/18382686
Funderburg N., Luciano A.A., Jiang W., Rodriguez B., Sieg S.F., Lederman M.M. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One, 2008, Vol. 3, pp. e1915. URL: http://www.ncbi.nlm.nih.gov/pubmed/18382686.http://www.ncbi.nlm.nih.gov/pubmed/18382686
Benito J.M., Lopez M., Lozano S., Ballesteros C., Martinez P., Gonzalez-Lahoz J., Soriano V. Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr., 2005, Vol. 38, No. 4, pp. 373–381. URL: http://www.ncbi.nlm.nih.gov/pubmed/15764953.http://www.ncbi.nlm.nih.gov/pubmed/15764953
Benito J.M., Lopez M., Lozano S., Ballesteros C., Martinez P., Gonzalez-Lahoz J., Soriano V. Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr., 2005, Vol. 38, No. 4, pp. 373–381. URL: http://www.ncbi.nlm.nih.gov/pubmed/15764953.http://www.ncbi.nlm.nih.gov/pubmed/15764953
Lederman M.M., Calabrese L., Funderburg N.T., Clagett B., Medvik K., Bonilla H., Gripshover B., Salata R.A., Taege A., Lisgaris M., McComsey G.A., Kirchner E., Baum J., Shive C., Asaad R., Kalayjian R.C., Sieg S.F., Rodriguez B. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J. Infect. Dis., 2011, Vol. 204, No. 8, pp. 1217–1226. URL: http://www.ncbi.nlm.nih.gov/pubmed/21917895.http://www.ncbi.nlm.nih.gov/pubmed/21917895
Lederman M.M., Calabrese L., Funderburg N.T., Clagett B., Medvik K., Bonilla H., Gripshover B., Salata R.A., Taege A., Lisgaris M., McComsey G.A., Kirchner E., Baum J., Shive C., Asaad R., Kalayjian R.C., Sieg S.F., Rodriguez B. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J. Infect. Dis., 2011, Vol. 204, No. 8, pp. 1217–1226. URL: http://www.ncbi.nlm.nih.gov/pubmed/21917895.http://www.ncbi.nlm.nih.gov/pubmed/21917895
Hunt P.W., Brenchley J., Sinclair E., McCune J.M., Roland M., Page-Shafer K., Hsue P., Emu B., Krone M., Lampiris H., Douek D., Martin J.N., Deeks S.G. Relationship between T cell activation and CD4(+) T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis., 2008, Vol. 197, No. 1, pp. 126–133. URL: ://WOS:000252399000020.://WOS:000252399000020
Hunt P.W., Brenchley J., Sinclair E., McCune J.M., Roland M., Page-Shafer K., Hsue P., Emu B., Krone M., Lampiris H., Douek D., Martin J.N., Deeks S.G. Relationship between T cell activation and CD4(+) T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis., 2008, Vol. 197, No. 1, pp. 126–133. URL: ://WOS:000252399000020.://WOS:000252399000020
Hunt P.W., Martin J.N., Sinclair E., Bredt B., Hagos E., Lampiris H., Deeks S.G. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J. Infect. Dis., 2003, Vol. 187, No. 10, pp. 1534–1543. URL: http://www.ncbi.nlm.nih.gov/pubmed/12721933.http://www.ncbi.nlm.nih.gov/pubmed/12721933
Hunt P.W., Martin J.N., Sinclair E., Bredt B., Hagos E., Lampiris H., Deeks S.G. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J. Infect. Dis., 2003, Vol. 187, No. 10, pp. 1534–1543. URL: http://www.ncbi.nlm.nih.gov/pubmed/12721933.http://www.ncbi.nlm.nih.gov/pubmed/12721933
Marchetti G., Gori A., Casabianca A., Magnani M., Franzetti F., Clerici M., Perno C.F., Monforte A., Galli M., Meroni L. Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART. AIDS, 2006, Vol. 20, No. 13, pp. 1727–1736. URL: http://www.ncbi.nlm.nih.gov/pubmed/16931937.http://www.ncbi.nlm.nih.gov/pubmed/16931937
Marchetti G., Gori A., Casabianca A., Magnani M., Franzetti F., Clerici M., Perno C.F., Monforte A., Galli M., Meroni L. Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART. AIDS, 2006, Vol. 20, No. 13, pp. 1727–1736. URL: http://www.ncbi.nlm.nih.gov/pubmed/16931937.http://www.ncbi.nlm.nih.gov/pubmed/16931937
Massanella M., Negredo E., Perez-Alvarez N., Puig J., Ruiz-Hernandez R., Bofill M., Clotet B., Blanco J. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS, 2010, Vol. 24, No. 7, pp. 959–968. URL: http://www.ncbi.nlm.nih.gov/pubmed/20177358.http://www.ncbi.nlm.nih.gov/pubmed/20177358
Massanella M., Negredo E., Perez-Alvarez N., Puig J., Ruiz-Hernandez R., Bofill M., Clotet B., Blanco J. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS, 2010, Vol. 24, No. 7, pp. 959–968. URL: http://www.ncbi.nlm.nih.gov/pubmed/20177358.http://www.ncbi.nlm.nih.gov/pubmed/20177358
Massanella M., Curriu M., Carrillo J., Gomez E., Puig J., Navarro J., Dalmau J., Martinez-Picado J., Crespo M., Cabrera C., Negredo E., Clotet B., Blanco J. Assessing main death pathways in T lymphocytes from HIV infected individuals. Cytometry A., 2013, Vol. 83, No. 7, pp. 648–658. URL: http://www.ncbi.nlm.nih.gov/pubmed/23650261.http://www.ncbi.nlm.nih.gov/pubmed/23650261
Massanella M., Curriu M., Carrillo J., Gomez E., Puig J., Navarro J., Dalmau J., Martinez-Picado J., Crespo M., Cabrera C., Negredo E., Clotet B., Blanco J. Assessing main death pathways in T lymphocytes from HIV infected individuals. Cytometry A., 2013, Vol. 83, No. 7, pp. 648–658. URL: http://www.ncbi.nlm.nih.gov/pubmed/23650261.http://www.ncbi.nlm.nih.gov/pubmed/23650261
Benveniste O., Flahault A., Rollot F., Elbim C., Estaquier J., Pedron B., Duval X., Dereuddre-Bosquet N., Clayette P., Sterkers G., Simon A., Ameisen J.C., Leport C. Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads. J. Infect. Dis., 2005, Vol. 191, No. 10, pp. 1670–1679. URL: http://www.ncbi.nlm.nih.gov/pubmed/15838794.http://www.ncbi.nlm.nih.gov/pubmed/15838794
Benveniste O., Flahault A., Rollot F., Elbim C., Estaquier J., Pedron B., Duval X., Dereuddre-Bosquet N., Clayette P., Sterkers G., Simon A., Ameisen J.C., Leport C. Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads. J. Infect. Dis., 2005, Vol. 191, No. 10, pp. 1670–1679. URL: http://www.ncbi.nlm.nih.gov/pubmed/15838794.http://www.ncbi.nlm.nih.gov/pubmed/15838794
Negredo E., Massanella M., Puig J., Perez-Alvarez N., Gallego-Escuredo J.M., Villarroya J., Villarroya F., Molto J., Santos J.R., Clotet B., Blanco J. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin. Infect. Dis., 2010, Vol. 50, No. 9, pp. 1300–1308. URL: http://www.ncbi.nlm.nih.gov/pubmed/20367229.http://www.ncbi.nlm.nih.gov/pubmed/20367229
Negredo E., Massanella M., Puig J., Perez-Alvarez N., Gallego-Escuredo J.M., Villarroya J., Villarroya F., Molto J., Santos J.R., Clotet B., Blanco J. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin. Infect. Dis., 2010, Vol. 50, No. 9, pp. 1300–1308. URL: http://www.ncbi.nlm.nih.gov/pubmed/20367229.http://www.ncbi.nlm.nih.gov/pubmed/20367229
Erikstrup C., Kronborg G., Lohse N., Ostrowski S.R., Gerstoft J., Ullum H. T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication. J. Acquir. Immune Defic. Syndr., 2010, Vol. 53, No. 3, pp. 303–310. URL: http://www.ncbi.nlm.nih.gov/pubmed/20048679.http://www.ncbi.nlm.nih.gov/pubmed/20048679
Erikstrup C., Kronborg G., Lohse N., Ostrowski S.R., Gerstoft J., Ullum H. T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication. J. Acquir. Immune Defic. Syndr., 2010, Vol. 53, No. 3, pp. 303–310. URL: http://www.ncbi.nlm.nih.gov/pubmed/20048679.http://www.ncbi.nlm.nih.gov/pubmed/20048679
Mendez-Lagares G., Garcia-Perganeda A., del Mar del Pozo-Balado M., Genebat M., Ruiz-Mateos E., Garcia Garcia M., Munoz-Fernandez M.A., Pacheco Y.M., Leal M. Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration. J. Antimicrob. Chemother., 2012, Vol. 67, No. 5, pp. 1228–1237. URL: http://www.ncbi.nlm.nih.gov/pubmed/22287235.http://www.ncbi.nlm.nih.gov/pubmed/22287235
Mendez-Lagares G., Garcia-Perganeda A., del Mar del Pozo-Balado M., Genebat M., Ruiz-Mateos E., Garcia Garcia M., Munoz-Fernandez M.A., Pacheco Y.M., Leal M. Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration. J. Antimicrob. Chemother., 2012, Vol. 67, No. 5, pp. 1228–1237. URL: http://www.ncbi.nlm.nih.gov/pubmed/22287235.http://www.ncbi.nlm.nih.gov/pubmed/22287235
Grabmeier-Pfistershammer K., Steinberger P., Rieger A., Leitner J., Kohrgruber N. Identification of PD-1 as a unique marker for failing immune reconstitution in HIV-1-infected patients on treatment. J. Acquir. Immune Defic. Syndr., 2011, Vol. 56, No. 2, pp. 118–124. URL: http://www.ncbi.nlm.nih.gov/pubmed/20980914.http://www.ncbi.nlm.nih.gov/pubmed/20980914
Grabmeier-Pfistershammer K., Steinberger P., Rieger A., Leitner J., Kohrgruber N. Identification of PD-1 as a unique marker for failing immune reconstitution in HIV-1-infected patients on treatment. J. Acquir. Immune Defic. Syndr., 2011, Vol. 56, No. 2, pp. 118–124. URL: http://www.ncbi.nlm.nih.gov/pubmed/20980914.http://www.ncbi.nlm.nih.gov/pubmed/20980914
Nakanjako D., Ssewanyana I., Mayanja-Kizza H., Kiragga A., Colebunders R., Manabe Y.C., Nabatanzi R., Kamya M.R., Cao H. High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort. BMC Infect. Dis., 2011, Vol. 11, pp. 43. URL: http://www.ncbi.nlm.nih.gov/pubmed/21299909.http://www.ncbi.nlm.nih.gov/pubmed/21299909
Nakanjako D., Ssewanyana I., Mayanja-Kizza H., Kiragga A., Colebunders R., Manabe Y.C., Nabatanzi R., Kamya M.R., Cao H. High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort. BMC Infect. Dis., 2011, Vol. 11, pp. 43. URL: http://www.ncbi.nlm.nih.gov/pubmed/21299909.http://www.ncbi.nlm.nih.gov/pubmed/21299909
Wherry E.J., Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol., 2015, Vol. 15, No. 8, pp. 486–499.
URL: http://www.ncbi.nlm.nih.gov/pubmed/26205583.http://www.ncbi.nlm.nih.gov/pubmed/26205583
URL: http://www.ncbi.nlm.nih.gov/pubmed/26205583.http://www.ncbi.nlm.nih.gov/pubmed/26205583
Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., Freeman G.J., Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature, 2006, Vol. 439, No. 7077, pp. 682–687. URL: http://www.ncbi.nlm.nih.gov/pubmed/16382236.http://www.ncbi.nlm.nih.gov/pubmed/16382236
Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., Freeman G.J., Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature, 2006, Vol. 439, No. 7077, pp. 682–687. URL: http://www.ncbi.nlm.nih.gov/pubmed/16382236.http://www.ncbi.nlm.nih.gov/pubmed/16382236
Florence E., Lundgren J., Dreezen C., Fisher M., Kirk O., Blaxhult A., Panos G., Katlama C., Vella S., Phillips A., Euro S.S.G. Factors associated with a reduced CD4 lymphocyte count response to HAART despite full viral suppression in the EuroSIDA study. HIV Med., 2003, Vol. 4, No. 3, pp. 255–262. URL: http://www.ncbi.nlm.nih.gov/pubmed/12859325.http://www.ncbi.nlm.nih.gov/pubmed/12859325
Florence E., Lundgren J., Dreezen C., Fisher M., Kirk O., Blaxhult A., Panos G., Katlama C., Vella S., Phillips A., Euro S.S.G. Factors associated with a reduced CD4 lymphocyte count response to HAART despite full viral suppression in the EuroSIDA study. HIV Med., 2003, Vol. 4, No. 3, pp. 255–262. URL: http://www.ncbi.nlm.nih.gov/pubmed/12859325.http://www.ncbi.nlm.nih.gov/pubmed/12859325
Isgro A., Leti W., De Santis W., Marziali M., Esposito A., Fimiani C., Luzi G., Pinti M., Cossarizza A., Aiuti F., Mezzaroma I. Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART. Clin. Infect. Dis., 2008, Vol. 46, No. 12, pp. 1902–1910. URL: http://www.ncbi.nlm.nih.gov/pubmed/18462177.http://www.ncbi.nlm.nih.gov/pubmed/18462177
Isgro A., Leti W., De Santis W., Marziali M., Esposito A., Fimiani C., Luzi G., Pinti M., Cossarizza A., Aiuti F., Mezzaroma I. Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART. Clin. Infect. Dis., 2008, Vol. 46, No. 12, pp. 1902–1910. URL: http://www.ncbi.nlm.nih.gov/pubmed/18462177.http://www.ncbi.nlm.nih.gov/pubmed/18462177
Tanaskovic S., Fernandez S., French M.A., Price R.I., Song S., Robins P.D., Price P. Thymic tissue is not evident on high-resolution computed tomography and [(1)(8)F]fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4(+) T cells. AIDS, 2011, Vol. 25, No. 9, pp. 1235–1237. URL: http://www.ncbi.nlm.nih.gov/pubmed/21505302.http://www.ncbi.nlm.nih.gov/pubmed/21505302
Tanaskovic S., Fernandez S., French M.A., Price R.I., Song S., Robins P.D., Price P. Thymic tissue is not evident on high-resolution computed tomography and [(1)(8)F]fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4(+) T cells. AIDS, 2011, Vol. 25, No. 9, pp. 1235–1237. URL: http://www.ncbi.nlm.nih.gov/pubmed/21505302.http://www.ncbi.nlm.nih.gov/pubmed/21505302
Teixeira L., Valdez H., McCune J.M., Koup R.A., Badley A.D., Hellerstein M.K., Napolitano L.A., Douek D.C., Mbisa G., Deeks S., Harris J.M., Barbour J.D., Gross B.H., Francis I.R., Halvorsen R., Asaad R., Lederman M.M. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS, 2001, Vol. 15, No. 14, pp. 1749–1756. URL: http://www.ncbi.nlm.nih.gov/pubmed/11579235.http://www.ncbi.nlm.nih.gov/pubmed/11579235
Teixeira L., Valdez H., McCune J.M., Koup R.A., Badley A.D., Hellerstein M.K., Napolitano L.A., Douek D.C., Mbisa G., Deeks S., Harris J.M., Barbour J.D., Gross B.H., Francis I.R., Halvorsen R., Asaad R., Lederman M.M. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS, 2001, Vol. 15, No. 14, pp. 1749–1756. URL: http://www.ncbi.nlm.nih.gov/pubmed/11579235.http://www.ncbi.nlm.nih.gov/pubmed/11579235
Li T., Wu N., Dai Y., Qiu Z., Han Y., Xie J., Zhu T., Li Y. Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin. Infect. Dis., 2011, Vol. 53, No. 9, pp. 944–951. URL: http://www.ncbi.nlm.nih.gov/pub -med/21960716.http://www.ncbi.nlm.nih.gov/pub
Li T., Wu N., Dai Y., Qiu Z., Han Y., Xie J., Zhu T., Li Y. Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin. Infect. Dis., 2011, Vol. 53, No. 9, pp. 944–951. URL: http://www.ncbi.nlm.nih.gov/pub -med/21960716.http://www.ncbi.nlm.nih.gov/pub
Marziali M., De Santis W., Carello R., Leti W., Esposito A., Isgro A., Fimiani C., Sirianni M.C., Mezzaroma I., Aiuti F. T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART. AIDS, 2006, Vol. 20, No. 16, pp. 2033–2041. URL: http://www.ncbi.nlm.nih.gov/pubmed/17053349.http://www.ncbi.nlm.nih.gov/pubmed/17053349
Marziali M., De Santis W., Carello R., Leti W., Esposito A., Isgro A., Fimiani C., Sirianni M.C., Mezzaroma I., Aiuti F. T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART. AIDS, 2006, Vol. 20, No. 16, pp. 2033–2041. URL: http://www.ncbi.nlm.nih.gov/pubmed/17053349.http://www.ncbi.nlm.nih.gov/pubmed/17053349
Colle J.H., Moreau J.L., Fontanet A., Lambotte O., Joussemet M., Jacod S., Delfraissy J.F., Theze J. Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients — effects of antiretroviral therapy. J. Acquir. Immune Defic. Syndr., 2006, Vol. 42, No. 3, pp. 277–285. URL: http://www.ncbi.nlm.nih.gov/pubmed/16810123.http://www.ncbi.nlm.nih.gov/pubmed/16810123
Colle J.H., Moreau J.L., Fontanet A., Lambotte O., Joussemet M., Jacod S., Delfraissy J.F., Theze J. Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients — effects of antiretroviral therapy. J. Acquir. Immune Defic. Syndr., 2006, Vol. 42, No. 3, pp. 277–285. URL: http://www.ncbi.nlm.nih.gov/pubmed/16810123.http://www.ncbi.nlm.nih.gov/pubmed/16810123
Bellistri G.M., Casabianca A., Merlini E., Orlandi C., Ferrario G., Meroni L., Galli M., Magnani M., Monforte A., Marchetti G. Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy. PLoS One, 2010, Vol. 5, pp. e15663. URL: http://www.ncbi.nlm.nih.gov/pubmed/21209878.http://www.ncbi.nlm.nih.gov/pubmed/21209878
Bellistri G.M., Casabianca A., Merlini E., Orlandi C., Ferrario G., Meroni L., Galli M., Magnani M., Monforte A., Marchetti G. Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy. PLoS One, 2010, Vol. 5, pp. e15663. URL: http://www.ncbi.nlm.nih.gov/pubmed/21209878.http://www.ncbi.nlm.nih.gov/pubmed/21209878
Hodge J.N., Srinivasula S., Hu Z., Read S.W., Porter B.O., Kim I., Mican J.M., Paik C., Degrange P., Di Mascio M., Sereti I. Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance. Blood, 2011, Vol. 118, No. 12, pp. 3244–3253. URL: http://www.ncbi.nlm.nih.gov/pubmed/21778338.http://www.ncbi.nlm.nih.gov/pubmed/21778338
Hodge J.N., Srinivasula S., Hu Z., Read S.W., Porter B.O., Kim I., Mican J.M., Paik C., Degrange P., Di Mascio M., Sereti I. Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance. Blood, 2011, Vol. 118, No. 12, pp. 3244–3253. URL: http://www.ncbi.nlm.nih.gov/pubmed/21778338.http://www.ncbi.nlm.nih.gov/pubmed/21778338
Schacker T.W., Brenchley J.M., Beilman G.J., Reilly C., Pambuccian S.E., Taylor J., Skarda D., Larson M., Douek D.C., Haase A.T. Lymphatic tissue fibrosis is associated with reduced numbers of I CD4(+) T cells in human immunodeficiency virus type 1 infection. Clin. Vaccine Immunol., 2006, Vol. 13, No. 5, pp. 556–560. URL: ://WOS:000237506500005.://WOS:000237506500005
Schacker T.W., Brenchley J.M., Beilman G.J., Reilly C., Pambuccian S.E., Taylor J., Skarda D., Larson M., Douek D.C., Haase A.T. Lymphatic tissue fibrosis is associated with reduced numbers of I CD4(+) T cells in human immunodeficiency virus type 1 infection. Clin. Vaccine Immunol., 2006, Vol. 13, No. 5, pp. 556–560. URL: ://WOS:000237506500005.://WOS:000237506500005
Schacker T.W., Nguyen P.L., Beilman G.J., Wolinsky S., Larson M., Reilly C., Haase A.T. Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis. J. Clin. Invest., 2002, Vol. 110, No. 8, pp. 1133–1139. URL: ://WOS:000178793700012.://WOS:000178793700012
Schacker T.W., Nguyen P.L., Beilman G.J., Wolinsky S., Larson M., Reilly C., Haase A.T. Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis. J. Clin. Invest., 2002, Vol. 110, No. 8, pp. 1133–1139. URL: ://WOS:000178793700012.://WOS:000178793700012
Zeng M., Smith A.J., Wietgrefe S.W., Southern P.J., Schacker T.W., Reilly C.S., Estes J.D., Burton G.F., Silvestri G., Lifson J.D., Carlis J.V., Haase A.T. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J. Clin. Invest., 2011, Vol. 121, No. 3, pp. 998–1008. URL: ://WOS:000287991000020.://WOS:000287991000020
Zeng M., Smith A.J., Wietgrefe S.W., Southern P.J., Schacker T.W., Reilly C.S., Estes J.D., Burton G.F., Silvestri G., Lifson J.D., Carlis J.V., Haase A.T. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J. Clin. Invest., 2011, Vol. 121, No. 3, pp. 998–1008. URL: ://WOS:000287991000020.://WOS:000287991000020
Capitini C.M., Chisti A.A., Mackall C.L. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J. Intern. Med., 2009, Vol. 266,
No. 2, pp. 141–153. URL: ://WOS:000267883100001.://WOS:000267883100001
No. 2, pp. 141–153. URL: ://WOS:000267883100001.://WOS:000267883100001
D’Amico R., Yang Y., Mildvan D., Evans S.R., Schnizlein-Bick C.T., Hafner R., Webb N., Basar M., Zackin R., Jacobson M.A. Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067. J. Clin. Immunol., 2005, Vol. 25, No. 2, pp. 106–115. URL: http://www.ncbi.nlm.nih.gov/pubmed/15821887.http://www.ncbi.nlm.nih.gov/pubmed/15821887
D’Amico R., Yang Y., Mildvan D., Evans S.R., Schnizlein-Bick C.T., Hafner R., Webb N., Basar M., Zackin R., Jacobson M.A. Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067. J. Clin. Immunol., 2005, Vol. 25, No. 2, pp. 106–115. URL: http://www.ncbi.nlm.nih.gov/pubmed/15821887.http://www.ncbi.nlm.nih.gov/pubmed/15821887
Moore R.D., Keruly J.C. CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin. Infect. Dis., 2007, Vol. 44, No. 3, pp. 441–446. URL: http://www.ncbi.nlm.nih.gov/pubmed/17205456.http://www.ncbi.nlm.nih.gov/pubmed/17205456
Moore R.D., Keruly J.C. CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin. Infect. Dis., 2007, Vol. 44, No. 3, pp. 441–446. URL: http://www.ncbi.nlm.nih.gov/pubmed/17205456.http://www.ncbi.nlm.nih.gov/pubmed/17205456
Gandhi R.T., Spritzler J., Chan E., Asmuth D.M., Rodriguez B., Merigan T.C., Hirsch M.S., Shafer R.W., Robbins G.K., Pollard R.B., Team A. Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384. J. Acquir. Immune Defic. Syndr., 2006, Vol. 42, No. 4, pp. 426–434. URL: http://www.ncbi.nlm.nih.gov/pub -med/16810109.http://www.ncbi.nlm.nih.gov/pub
Gandhi R.T., Spritzler J., Chan E., Asmuth D.M., Rodriguez B., Merigan T.C., Hirsch M.S., Shafer R.W., Robbins G.K., Pollard R.B., Team A. Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384. J. Acquir. Immune Defic. Syndr., 2006, Vol. 42, No. 4, pp. 426–434. URL: http://www.ncbi.nlm.nih.gov/pub -med/16810109.http://www.ncbi.nlm.nih.gov/pub
Marcus J.L., Leyden W.A., Chao C.R., Xu L., Quesenberry C.P., Jr., Tien P.C., Klein D.B., Towner W.J., Horberg M.A., Silverberg M.J. Differences in response to antiretroviral therapy by sex and hepatitis C infection status. AIDS Patient Care STDS, 2015, Vol. 29, No. 7, pp. 370– 378. URL: http://www.ncbi.nlm.nih.gov/pubmed/26061798.http://www.ncbi.nlm.nih.gov/pubmed/26061798
Marcus J.L., Leyden W.A., Chao C.R., Xu L., Quesenberry C.P., Jr., Tien P.C., Klein D.B., Towner W.J., Horberg M.A., Silverberg M.J. Differences in response to antiretroviral therapy by sex and hepatitis C infection status. AIDS Patient Care STDS, 2015, Vol. 29, No. 7, pp. 370– 378. URL: http://www.ncbi.nlm.nih.gov/pubmed/26061798.http://www.ncbi.nlm.nih.gov/pubmed/26061798
Greub G., Ledergerber B., Battegay M., Grob P., Perrin L., Furrer H., Burgisser P., Erb P., Boggian K., Piffaretti J.C., Hirschel B., Janin P., Francioli P., Flepp M., Telenti A. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet, 2000, Vol. 356, No. 9244, pp. 1800–1805. URL: http://www.ncbi.nlm.nih.gov/pubmed/11117912.http://www.ncbi.nlm.nih.gov/pubmed/11117912
Greub G., Ledergerber B., Battegay M., Grob P., Perrin L., Furrer H., Burgisser P., Erb P., Boggian K., Piffaretti J.C., Hirschel B., Janin P., Francioli P., Flepp M., Telenti A. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet, 2000, Vol. 356, No. 9244, pp. 1800–1805. URL: http://www.ncbi.nlm.nih.gov/pubmed/11117912.http://www.ncbi.nlm.nih.gov/pubmed/11117912
Potter M., Odueyungbo A., Yang H., Saeed S., Klein M.B., Canadian Co-infection Cohort Study I. Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy. AIDS, 2010, Vol. 24, No. 12, pp. 1857–1865. URL: http://www.ncbi.nlm.nih.gov/pubmed/20479633.http://www.ncbi.nlm.nih.gov/pubmed/20479633
Potter M., Odueyungbo A., Yang H., Saeed S., Klein M.B., Canadian Co-infection Cohort Study I. Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy. AIDS, 2010, Vol. 24, No. 12, pp. 1857–1865. URL: http://www.ncbi.nlm.nih.gov/pubmed/20479633.http://www.ncbi.nlm.nih.gov/pubmed/20479633
Hogg R., Lima V., Sterne J., Grabar S., Battegay M., Bonarek M., Monforte A., Esteve A., Gill M., Harris R., Justice A. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet, 2008, Vol. 372, No. 9635, pp. 293–299. URL: http://www.ncbi.nlm.nih.gov/pubmed/18657708.http://www.ncbi.nlm.nih.gov/pubmed/18657708
Hogg R., Lima V., Sterne J., Grabar S., Battegay M., Bonarek M., Monforte A., Esteve A., Gill M., Harris R., Justice A. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet, 2008, Vol. 372, No. 9635, pp. 293–299. URL: http://www.ncbi.nlm.nih.gov/pubmed/18657708.http://www.ncbi.nlm.nih.gov/pubmed/18657708
Piketty C., Weiss L., Thomas F., Mohamed A.S., Belec L., Kazatchkine M.D. Long-term clinical outcome of human immunodeficiency virusinfected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. J. Infect. Dis., 2001, Vol. 183, No. 9, pp. 1328–1335. URL: http://www.ncbi.nlm.nih.gov/pubmed/11294663.http://www.ncbi.nlm.nih.gov/pubmed/11294663
Piketty C., Weiss L., Thomas F., Mohamed A.S., Belec L., Kazatchkine M.D. Long-term clinical outcome of human immunodeficiency virusinfected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. J. Infect. Dis., 2001, Vol. 183, No. 9, pp. 1328–1335. URL: http://www.ncbi.nlm.nih.gov/pubmed/11294663.http://www.ncbi.nlm.nih.gov/pubmed/11294663
Damtie D., Yismaw G., Woldeyohannes D., Anagaw B. Common opportunistic infections and their CD4 cell correlates among HIV-infected patients attending at antiretroviral therapy clinic of Gondar University Hospital, Northwest Ethiopia. BMC Res. Notes, 2013, Vol. 6, pp. 534. URL: http://www.ncbi.nlm.nih.gov/pubmed/24330921.http://www.ncbi.nlm.nih.gov/pubmed/24330921
Damtie D., Yismaw G., Woldeyohannes D., Anagaw B. Common opportunistic infections and their CD4 cell correlates among HIV-infected patients attending at antiretroviral therapy clinic of Gondar University Hospital, Northwest Ethiopia. BMC Res. Notes, 2013, Vol. 6, pp. 534. URL: http://www.ncbi.nlm.nih.gov/pubmed/24330921.http://www.ncbi.nlm.nih.gov/pubmed/24330921
Severe P., Juste M.A., Ambroise A., Eliacin L., Marchand C., Apollon S., Edwards A., Bang H., Nicotera J., Godfrey C., Gulick R.M., Johnson W.D., Jr., Pape J.W., Fitzgerald D.W. Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N. Engl. J. Med., 2010, Vol. 363, No. 3, pp. 257–265. URL: http://www.ncbi.nlm.nih.gov/pubmed/20647201.http://www.ncbi.nlm.nih.gov/pubmed/20647201
Severe P., Juste M.A., Ambroise A., Eliacin L., Marchand C., Apollon S., Edwards A., Bang H., Nicotera J., Godfrey C., Gulick R.M., Johnson W.D., Jr., Pape J.W., Fitzgerald D.W. Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N. Engl. J. Med., 2010, Vol. 363, No. 3, pp. 257–265. URL: http://www.ncbi.nlm.nih.gov/pubmed/20647201.http://www.ncbi.nlm.nih.gov/pubmed/20647201
Kaplan R.C., Kingsley L.A., Gange S.J., Benning L., Jacobson L.P., Lazar J., Anastos K., Tien P.C., Sharrett A.R., Hodis H.N. Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS, 2008, Vol. 22, No. 13, pp. 1615–1624. URL: http://www.ncbi.nlm.nih.gov/pubmed/18670221.http://www.ncbi.nlm.nih.gov/pubmed/18670221
Kaplan R.C., Kingsley L.A., Gange S.J., Benning L., Jacobson L.P., Lazar J., Anastos K., Tien P.C., Sharrett A.R., Hodis H.N. Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS, 2008, Vol. 22, No. 13, pp. 1615–1624. URL: http://www.ncbi.nlm.nih.gov/pubmed/18670221.http://www.ncbi.nlm.nih.gov/pubmed/18670221
Phillips A.N., Neaton J., Lundgren J.D. The role of HIV in serious diseases other than AIDS. AIDS, 2008, Vol. 22, No. 18, pp. 2409–2418.
URL: http://www.ncbi.nlm.nih.gov/pubmed/19005264.http://www.ncbi.nlm.nih.gov/pubmed/19005264
URL: http://www.ncbi.nlm.nih.gov/pubmed/19005264.http://www.ncbi.nlm.nih.gov/pubmed/19005264
Ho J.E., Scherzer R., Hecht F.M., Maka K., Selby V., Martin J.N., Ganz P., Deeks S.G., Hsue P.Y. The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease. AIDS, 2012, Vol. 26, No. 9, pp. 1115–1120. URL: http://www.ncbi.nlm.nih.gov/pubmed/22382147.http://www.ncbi.nlm.nih.gov/pubmed/22382147
Ho J.E., Scherzer R., Hecht F.M., Maka K., Selby V., Martin J.N., Ganz P., Deeks S.G., Hsue P.Y. The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease. AIDS, 2012, Vol. 26, No. 9, pp. 1115–1120. URL: http://www.ncbi.nlm.nih.gov/pubmed/22382147.http://www.ncbi.nlm.nih.gov/pubmed/22382147
van Lelyveld S.F., Gras L., Kesselring A., Zhang S., De Wolf F., Wensing A.M., Hoepelman A.I., study A.n.o.c. Long-term complications in patients with poor immunological recovery despite virological successful HAART in Dutch ATHENA cohort. AIDS, 2012, Vol. 26, No. 4, pp. 465– 474. URL: http://www.ncbi.nlm.nih.gov/pubmed/22112603.http://www.ncbi.nlm.nih.gov/pubmed/22112603
van Lelyveld S.F., Gras L., Kesselring A., Zhang S., De Wolf F., Wensing A.M., Hoepelman A.I., study A.n.o.c. Long-term complications in patients with poor immunological recovery despite virological successful HAART in Dutch ATHENA cohort. AIDS, 2012, Vol. 26, No. 4, pp. 465– 474. URL: http://www.ncbi.nlm.nih.gov/pubmed/22112603.http://www.ncbi.nlm.nih.gov/pubmed/22112603
Deeks S.G. HIV infection, inflammation, immunosenescence, and aging. Annu. Rev. Med., 2011, Vol. 62, pp. 141–155. URL: ISI>://WOS:000287956900011.ISI>://WOS:000287956900011
Deeks S.G. HIV infection, inflammation, immunosenescence, and aging. Annu. Rev. Med., 2011, Vol. 62, pp. 141–155. URL: ISI>://WOS:000287956900011.ISI>://WOS:000287956900011