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Статья; ОбзорИскать документыПерейти к записи. 2023; Т. 15, № 2: 7–18. DOI:10.22328/2077-9828-2023-15-2-7-18
Иммунологическая неэффективность антиретровирусной терапии у ВИЧ-инфицированных пациентов
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Аффилированные организации
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Аннотация

Широкое внедрение и раннее назначение антиретровирусной терапии существенно улучшает прогноз у людей, живущих с ВИЧ (ЛЖВ),— с увеличением числа CD4+ T-лимфоцитов снижается частота развития вторичных заболеваний и уровень смертности.

У некоторых пациентов на АРТ не удается в полной степени восстановить иммунный статус, несмотря на подавление репликации ВИЧ. Известно, что данные пациенты имеют повышенные риски развития СПИД-ассоциированных болезней и заболеваний, не связанных с ВИЧ. В настоящее время не существует четких критериев для определения случая иммунологической неэффективности АРТ у пациента. Причины формирования недостаточного иммунного ответа изучены недостаточно. Представленный обзор направлен на привлечение внимания специалистов к этой проблеме — обобщены результаты последних исследований и современные данные литературы, описаны возможные механизмы и факторы риска развития иммунологической неэффективности АРТ; представлены исследуемые терапевтические стратегии, направленные на восстановление иммунного статуса у ВИЧ-инфицированных пациентов.

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Литература

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Дополнительная информация
Язык текста: Русский
ISSN: 2077-9828
Унифицированный идентификатор ресурса для цитирования: //medj.rucml.ru/journal/4e432d4849562d41525449434c452d323032332d31352d322d302d372d3138/