Дискуссионные вопросы профилактики целиакии

СтатьяМЕД СОВЕТ. 2015; № 14: 119–122. DOI:10.21518/2079-701X-2015-14-119-122

Захарова И. Н.^[1]

Дмитриева Ю.А.^[1]

Климов Л.Я.^[2]

Дзебисова Ф.С.^[1]

^[1]Российская медицинская академия последипломного образования (Москва)

^[2]Ставропольский государственный медицинский университет

С момента формирования современных представлений о патогенезе целиакии стало активно обсуждаться значение средовых факторов в ее развитии. Наибольший интерес ученых привлекало возможное влияние характера вскармливания ребенка в раннем возрасте на риск развития заболевания. В статье авторами проанализированы исследования, опубликованные в течение последних 15 лет, демонстрирующие изменение представлений о роли грудного вскармливания и сроков введения глю-тенсодержащих продуктов в патогенезе глютеновой энтеропатии. Результаты последних опубликованных крупных контролируемых исследований позволили достоверно показать, что возможность выработки оральной толерантности к глютену при целиакии как генетически детерминированном заболевании невозможно, при этом риск и сроки дебюта заболевания в первую очередь обусловлены особенностями генотипа пациентов.

целиакия

дети

профилактика

грудное вскармливание

сроки введения глютена

генотип

Боли

Больные

Генотип

Глиадин

Грудное вскармливание

Дети

Кинез

Обзор

Работа

Риск

Сталь

Характер

Целиакия

European Society for Pediatric Gastroenterology, HepatoLogy, and Nutrition Guidelines for the Diagnosis of CoeLiac Disease. JPGN, 2012. 54: 136-160.

Shan L, MoLberg O, Parrot I, Structural basis for gluten intolerance in celiac sprue. Science, 2002. 297: 2275-2279.

Dube C, Rostom A, Sy R et aL. The prevalence of celiac disease in average-risk and at-risk Western European popuLations: a systematic review. Gastroenterology, 2005. 128: S57-S67.

Greco L, Romino R, Coto I et aL. The first Large popuLation based twin study of coeLiac disease. Gut, 2002. 50: 624-8.

SoLLid LM. MoLecuLar basis of ceLiac disease. Annu Rev Immunol, 2000. 18: 53-81.

ToLLefsen S, Arentz-Hansen H, FLeckenstein B. et aL. HLA-DQ2 and -DQ8 signatures of gLuten T ceLL epitopes in ceLiac disease. J Clin Invest, 2006. Aug. 116(8): 2226-36.

WoLters VM, Wijmenga C. Genetic Background of CeLiac Disease and Its CLinicaL ImpLications. The Am J Gastroenterol, 2008. 103(1): 190-195.

PetronzeLLi F, Bonamico M, Ferrante P et aL. Genetic contribution of the HLA region to the famiLiaL cLustering of coeLiac disease. Ann Hum Genet, 1997. 61: 307-17.

Catassi C, Fasano A. CeLiac disease. Current opinion in Gastroenterology, 2008. 24: 687-691.

HoLopainen P, MustaLahti K, Uimari P et aL. Candidate gene regions and genetic heterogeneity in gLuten sensitivity. Gut, 2001. 48: 696-701.

Sandberg-Bennich S, DahLquist G, KaLLen B. CoeLiac disease is 12. associated with intrau-terine growth and neonataL infections. Acta Paediatr, 2002. 91(1): 30-3.

PLot L, AmitaL H. Infectious associations of CeLiac disease 15. Autoimmun Rev, 2009. 8(4): 316-9.

Forsberg G, FahLgren A, Horstedt P et aL. Presence of bacteria and innate immunity of intestinaL epitheLium in chiLdhood ceLiac disease. Am J Gastroenterol, 2004. 99: 894-904.

NadaL I, Donant E, Ribes-Koninckx C et aL. ImbaLance in the composition of the duodenaL microbiota of chiLdren with coeLiac disease. J Med Microbiol, 2007. 56: 1669-1674.

Ivarsson A. The Swedish epidemic of coeLiac disease expLored using an epidemioLogicaL approach-some Lessons to be Learnt. Best Pract Res Clin Gastroenterol, 2005. 19(3): 425-40.

Akobeng AK, Ramanan AV, Buchan I, HeLLer RF. Effect of breast feeding on risk of coeLiac disease: a systematic review and meta-anaLysis of observationaL studies. Arch Dis Child, 2006. 91(1): 39-43.

Ivarsson A, HerneLL O, StenLund H, Persson LA. Breast-feeding protects against ceLiac disease. Am J Clin Nutr, 2002. 75(5): 914-21.

Peters U, Schneeweiss S, Trautwein EA et aL. A case-control study of the effect of infant feeding on celiac disease. Ann Nutr Metab., 2001. 45(4): 135-42.

Auricchio S, FoLLo D, de Ritis G et aL. Does breastfeeding protect against the development of cLinicaL symptoms of ceLiac disease in chiLdren? Br I Community Nurs, 2003. 8: 127-L32.

Ascher H, Krantz I, Rydberg L et aL. Influence of infant feeding and gLuten intake on ceLiac disease. Arch Dis Childh, 1997. 76: 113-17.

Greco L, Auricchio S, Mayer M et al. Case control study on nutritionaL risk factors in ceLiac disease. J Pediatr Gastroenterol Nutr., 1988. 7(3): 395-9.

FaLth-Magnusson K, Franzen L, Jansson G et aL. Infant feeding history shows distinct differences between Swedish ceLiac and reference chiLdren. Pediatr Allergy Immunol, 1996. 7(1): 1-5.

Henriksson C, Bostrom AM, WikLund iE. What effect does breastfeeding have on coeLiac disease? A systematic review update. Evid Based Med, 2013. 18(3): 98-103.

Roman E. EnvironmentaL factors in ceLiac disease: a nationwide case-controL study. J Pediatr Gastroenterol Nutr, 2010. 50(SuppL 2): E74-5.

RadLovic NP, MLadenovic MM, Lekovic ZM et aL. InfLuence of earLy feeding practices on ceLiac disease in infants. Croat Med J., 2010. 51(5): 417-22.

D'Amico MA, HoLmes J, StavropouLos SN et aL. Presentation of pediatric ceLiac disease in the United States: prominent effect of breastfeeding. Clin Pediatr (Phila), 2005. 44(3): 249-58.

Norris JM, Barriga K, KLingensmith G et aL. Risk of ceLiac disease autoimmunity and timing of gLuten introduction in the diet of infants at increased risk of disease. JAMA, 2005. 18. 293(19): 2343-51.

StordaL K, White RA, Eggesbo M. Early Feeding and Risk of CeLiac Disease in a Prospective Birth Cohort. Pediatrics, 2013. 132(5): e1202-e1209.

Prescott SL, Smith P, Tang M et aL. The importance of earLy compLementary feeding in the deveLopment of oraL toLerance: concerns and controversies. Pediatr Allergy Immunol., 2008. 19(5): 375-80.

PooLe JA, Barriga K, Leung DY et aL. Timing of initiaL exposure to cereaL grains and the risk of wheat aLLergy. Pediatrics, 2006. 117(6): 2175-82.

Knip M, Virtanen SM, Becker D et aL. EarLy feeding and risk of type 1 diabetes: experiences from the TriaL to Reduce InsuLin-dependent diabetes meLLitus in the GeneticaLLy at Risk (TRIGR). Am J Clin Nutr, 2011. 94(6 SuppL): 1814S-1820S.

Agostoni C, Decsi T, FewtreLL M et aL. CompLementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr., 2008. 46(1): 99-110.

Vriezinga SL, Auricchio R, Bravi E et aL. Randomized Feeding Intervention in Infants at High Risk for CeLiac Disease. N Engl J Med, 2014. 371: 1304-1315.

Lionetti E, CasteLLaneta S, FrancaviLLa R et aL. Introduction of gLuten, HLA status, and the risk of ceLiac disease in chiLdren. N Engl J Med., 2014. 2. 371(14): 1295-1303.

Szajewska H, Shamir R, ChmieLewska A et aL. Systematic review with meta-anaLysis: earLy infant feeding and coeLiac disease-update 2015. Aliment Pharmacol Ther., 2015. 41(11): 1038-54.

Язык текста: Русский

ISSN: 2079-701X