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СтатьяИскать документыПерейти к записи. 2020; № 5: 104–112. DOI:10.21518/2079-701X-2020-5-104-112
Клиническая эффективность препаратов на основе пробиотических штаммов Saccharomyces boulardii
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Аффилированные организации
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Аннотация
Микрофлора кишечника в свете интегральной совокупности знаний о ее значимости для организма человека рассматривается в настоящее время как дополнительный «виртуальный» орган, продуцирующий множество биологически активных соединений, влияющих на различные свойства и функции макроорганизма: ферментацию неперевариваемых пищевых полисахаридов, поддержание оптимальных значений внутрипросветного рН и «кишечного барьера», активность иммунной системы, витаминный статус, энергетический гомеостаз, ангиогенез. Saccharomycesboulardii не является представителем естественной микрофлоры кишечника человека, но, применяемый как пробиотик, взаимодействует с ней, восстанавливая баланс короткоцепочечных жирных кислот, снижая уровни бактериальных токсинов, действуя как суррогатная нормальная микрофлора до момента восстановления и замещения естественными ее представителями. S. boulardii обладает иммуностимулирующей и противовоспалительной активностью. Результаты клинических исследований продемонстрировали эффективность применения S. boulardii при коррекции патологических состояний, ассоциированных с Helicobacterpylori, Clostridiumdifficile, Candidaalbicans, Salmonellatyphimurum, Yersiniaenterocolitium, простейшими рода Entamoeba, а также при лечении синдрома раздраженного кишечника и антибиотик-ассоциированной диареи. Эффективность лекарственного препарата, содержащего S. boulardii, продемонстрирована в статье результатами клинических исследований и клиническим примером. Этот лекарственный препарат зарекомендовал себя как высокоэффективное и безопасное пробиотическое средство, позволяющее предотвращать и лечить ряд заболеваний желудочно-кишечного тракта, обладающее физиологически-оптимизированным фармакодинамическим эффектом, имитирующим защитные свойства нормальной микрофлоры кишечника человека. При использовании лекарственного препарата, содержащего S. boulardii, как у взрослых, так и у детей не наблюдаются серьезные побочные эффекты, что расширяет возможности его безопасного применения в клинической практике.
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Рубрики Mesh
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Дополнительная информация
Язык текста: Русский
ISSN: 2079-701X
Унифицированный идентификатор ресурса для цитирования: //medj.rucml.ru/journal/4e432d4d4544534f5645542d41525449434c452d323032302d302d352d302d3130342d313132/