Capozza K., Gadd H., Kelley K., Russell S., Shi V., Schwartz A. Insights from Caregivers on the Impact of Pediatric Atopic Dermatitis on Families: “I’m Tired, Overwhelmed, and Feel Like I’m Failing as a Mother”. Dermatitis. 2020;31(3):223–227. https://doi.org/10.1097/DER.0000000000000582..
DOI: 10.1097/DER.0000000000000582
Silverberg J.I. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123(2):144–151. https://doi.org/10.1016/j.anai.2019.04.020..
DOI: 10.1016/j.anai.2019.04.020
Sun D., Ong P.Y. Infectious Complications in Atopic Dermatitis. Immunol Allergy Clin North Am. 2017;37(1):75–93. https://doi.org/10.1016/j.iac.2016.08.015..
DOI: 10.1016/j.iac.2016.08.015
Bjerre R.D., Bandier J., Skov L., Engstrand L., Johansen J.D. The role of the skin microbiome in atopic dermatitis: a systematic review. Br J Dermatol. 2017;177(5):1272–1278. https://doi.org/10.1111/bjd.15390..
DOI: 10.1111/bjd.15390
Silverberg J.I., Silverberg N.B. Childhood atopic dermatitis and warts are associated with increased risk of infection: a US population-based study. J Allergy Clin Immunol. 2014;133(4):1041–1047. https://doi.org/10.1016/j.jaci.2013.08.012..
DOI: 10.1016/j.jaci.2013.08.012
Narla S., Silverberg J.I. Association between atopic dermatitis and serious cutaneous, multiorgan, and systemic infections in US adults. Ann Allergy Asthma Immunol. 2018;120(1):66–72.e11. https://doi.org/10.1016/j.anai.2017.10.019..
DOI: 10.1016/j.anai.2017.10.019
Yang G., Seok J.K., Kang H.C., Cho Y.Y., Lee H.S., Lee J.Y. Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis. Int J Mol Sci. 2020;21(8):2867. https://doi.org/10.3390/ijms21082867..
DOI: 10.3390/ijms21082867
Jungersted J.M., Scheer H., Mempel M., Baurecht H., Cifuentes L., Høgh J.K. et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy. 2010;65(7):911–918. https://doi.org/10.1111/j.1398-9995.2010.02326.x..
DOI: 10.1111/j.1398-9995.2010.02326.x
Elias P.M., Wakefield J.S. Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol. 2014;134(4):781–791.e1. https://doi.org/10.1016/j.jaci.2014.05.048..
DOI: 10.1016/j.jaci.2014.05.048
Janssens M., van Smeden J., Gooris G.S., Bras W., Portale G., Caspers P.J. et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res. 2012;53(12):2755–2766. https://doi.org/10.1194/jlr.P030338..
DOI: 10.1194/jlr.P030338
Malik K., Heitmiller K.D., Czarnowicki T. An Update on the Pathophysiology of Atopic Dermatitis. Dermatol Clin. 2017;35(3):317–326. https://doi.org/10.1016/j.det.2017.02.006..
DOI: 10.1016/j.det.2017.02.006
Palmer C.N., Irvine A.D., Terron-Kwiatkowski A., Zhao Y., Liao H., Lee S.P. et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–446. https://doi.org/10.1038/ng1767..
DOI: 10.1038/ng1767
Szegedi A. Filaggrin mutations in early- and late-onset atopic dermatitis. Br J Dermatol. 2015;172(2):320–321. https://doi.org/10.1111/bjd.13534..
DOI: 10.1111/bjd.13534
Wolf R., Wolf D. Abnormal epidermal barrier in the pathogenesis of atopic dermatitis. Clin Dermatol. 2012;30(3):329–334. https://doi.org/10.1016/j.clindermatol.2011.08.023..
DOI: 10.1016/j.clindermatol.2011.08.023
Bergmann S., von Buenau B., Vidal-Y- Sy S., Haftek M., Wladykowski E., Houdek P. et al. Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently. Sci Rep. 2020;10(1):2024. https://doi.org/10.1038/s41598-020-58718-9..
DOI: 10.1038/s41598-020-58718-9
Tokumasu R., Yamaga K., Yamazaki Y., Murota H., Suzuki K., Tamura A. et al. Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 2016;113(28):E4061–E4068. https://doi.org/10.1073/pnas.1525474113..
DOI: 10.1073/pnas.1525474113
Yuki T., Komiya A., Kusaka A., Kuze T., Sugiyama Y., Inoue S. Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing. J Dermatol Sci. 2013;69(2):148–158. https://doi.org/10.1016/j.jdermsci.2012.11.595..
DOI: 10.1016/j.jdermsci.2012.11.595
Elias P.M., Sugarman J. Does moisturizing the skin equate with barrier repair therapy? Ann Allergy Asthma Immunol. 2018;121(6):653–e656.e2. https://doi.org/10.1016/j.anai.2018.07.008..
DOI: 10.1016/j.anai.2018.07.008
Ong P.Y., Leung D.Y. Bacterial and Viral Infections in Atopic Dermatitis: a Comprehensive Review. Clin Rev Allergy Immunol. 2016;51(3):329–337. https://doi.org/10.1007/s12016-016-8548-5..
DOI: 10.1007/s12016-016-8548-5
Kuo I.H., Carpenter-Mendini A., Yoshida T., McGirt L.Y., Ivanov A.I., Barnes K.C. et al. Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. J Invest Dermatol. 2013;133(4):988–998. https://doi.org/10.1038/jid.2012.437..
DOI: 10.1038/jid.2012.437
Leung D.Y. New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol Int. 2013;62(2):151–161. https://doi.org/10.2332/allergolint.13-RAI-0564..
DOI: 10.2332/allergolint.13-RAI-0564
Dainichi T., Kitoh A., Otsuka A., Nakajima S., Nomura T., Kaplan D.H., Kabashima K. The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. Nat Immunol. 2018;19(12):1286–1298. https://doi.org/10.1038/s41590-018-0256-2..
DOI: 10.1038/s41590-018-0256-2
Stier M.T., Peebles Jr R.S. Innate lymphoid cells and allergic disease. Ann Allergy Asthma Immunol. 2017;119(6):480–488. https://doi.org/10.1016/j.anai.2017.08.290..
DOI: 10.1016/j.anai.2017.08.290
Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T. et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;347(15):1151–1160. https://doi.org/10.1056/NEJMoa021481..
DOI: 10.1056/NEJMoa021481
Ryffel B., Alves-Filho J.C. ILC2s and Basophils Team Up to orchestrate IL-33-Induced Atopic Dermatitis. J Invest Dermatol. 2019;139(10):2077–2079. https://doi.org/10.1016/j.jid.2019.06.118..
DOI: 10.1016/j.jid.2019.06.118
Mack M.R., Brestoff J.R., Berrien-Elliott M.M., Trier A.M., Yang T.-L.B., McCullen M. et al. Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis. Sci Transl Med. 2020;12(532):eaay1005. https://doi.org/10.1126/scitranslmed.aay1005..
DOI: 10.1126/scitranslmed.aay1005
Kim J., Kim B.E., Ahn K., Leung D.Y.M. Interactions Between Atopic Dermatitis and Staphylococcus Aureus Infection: Clinical Implications. Allergy Asthma Immunol Res. 2019;11(5):593–603. https://doi.org/10.4168/aair.2019.11.5.593..
DOI: 10.4168/aair.2019.11.5.593
Orfali R.L., Yoshikawa F.S.Y., Oliveira L.M.D.S., Pereira N.Z., de Lima J.F., Ramos Y.A.L. et al. Staphylococcal enterotoxins modulate the effector CD4+ T cell response by reshaping the gene expression profile in adults with atopic dermatitis. Sci Rep. 2019;9(1):13082. https://doi.org/10.1038/s41598-019-49421-5..
DOI: 10.1038/s41598-019-49421-5
Nakatsuji T., Gallo R.L. The role of the skin microbiome in atopic dermatitis. Ann Allergy Asthma Immunol. 2019;122(3):263–269. https://doi.org/10.1016/j.anai.2018.12.003..
DOI: 10.1016/j.anai.2018.12.003
Wang V., Keefer M., Ong P.Y. Antibiotic choice and methicillin-resistant Staphylococcus aureus rate in children hospitalized for atopic dermatitis. Ann Allergy Asthma Immunol. 2019;122(3):314–317. https://doi.org/10.1016/j.anai.2018.12.001..
DOI: 10.1016/j.anai.2018.12.001
Hsu D.Y., Shinkai K., Silverberg J.I. Epidemiology of Eczema Herpeticum in Hospitalized U.S. Children: Analysis of a Nationwide Cohort. J Invest Dermatol. 2018;138(2):265–272. https://doi.org/10.1016/j.jid.2017.08.039..
DOI: 10.1016/j.jid.2017.08.039
Leung D.Y. Why is eczema herpeticum unexpectedly rare? Antiviral Res. 2013;98(2):153–157. https://doi.org/10.1016/j.antiviral.2013.02.010..
DOI: 10.1016/j.antiviral.2013.02.010
Woods M.T., Brown P.A., Baig-Lewis S.F., Simpson E.L. Effects of a novel formulation of fluocinonide 0.1[%] cream on skin barrier function in atopic dermatitis. J Drugs Dermatol. 2011;10(2):171–176. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156681/.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156681/
Dähnhardt-Pfeiffer S., Dähnhardt D., Buchner M., Walter K., Proksch E., Fölster-Holst R. Comparison of effects of tacrolimus ointment and mometasone furoate cream on the epidermal barrier of patients with atopic dermatitis. J Dtsch Dermatol Ges. 2013;11(5):437–443. https://doi.org/10.1111/ddg.12074..
DOI: 10.1111/ddg.12074
Hung S.H., Lin Y.T., Chu C.Y., Lee C.-C., Liang T.-C., Yang Y.-H. et al. Staphylococcus colonization in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics. Ann Allergy Asthma Immunol. 2007;98(1):51–56. https://doi.org/10.1016/S1081-1206(10)60859-9..
DOI: 10.1016/S1081-1206(10)60859-9
Gonzalez M.E., Schaffer J.V., Orlow S.J., Gao Z., Li H., Alekseyenko A.V., Blaser M.J. Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis. J Am Acad Dermatol. 2016;75(3):481–493.e8. https://doi.org/10.1016/j.jaad.2016.04.066..
DOI: 10.1016/j.jaad.2016.04.066
Boguniewicz M., Fonacier L., Guttman-Yassky E., Ong P.Y., Silverberg J., Farrar J.R. Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape. Ann Allergy Asthma Immunol. 2018;120(1):10–22.e2. https://doi.org/10.1016/j.anai.2017.10.039..
DOI: 10.1016/j.anai.2017.10.039