Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61–70. https://doi.org/10.1038/nature11412..
DOI: 10.1038/nature11412
Osborne C.K., Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu Rev Med. 2011;62:233–247. https://doi.org/10.1146/annurevmed-070909-182917..
DOI: 10.1146/annurevmed-070909-182917
Gottardis M.M., Jordan V.C. Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res. 1988;48(18):5183–5187. Available at: https://pubmed.ncbi.nlm.nih.gov/3409244/.https://pubmed.ncbi.nlm.nih.gov/3409244/
Gottardis M.M., Wagner R.J., Borden E.C., Jordan V.C. Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in Vivo and in Vitro. Cancer Res. 1989;49(17):4765–4769. Available at: https://pubmed.ncbi.nlm.nih.gov/2758410/.https://pubmed.ncbi.nlm.nih.gov/2758410/
Gottardis M.M., Jiang S.-Y., Jeng M.-H., Jordan V.С. Inhibition of tamoxifenstimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res. 1989;49(15):4090–4093. Available at: https://pubmed.ncbi.nlm.nih.gov/2743303/.https://pubmed.ncbi.nlm.nih.gov/2743303/
Gottardis M.M., Ricchio M.E., Satyaswaroop P.G., Jordan V.С. Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice. Cancer Res. 1990;50(11): 3189–3192. Available at: https://pubmed.ncbi.nlm.nih.gov/2334915/.https://pubmed.ncbi.nlm.nih.gov/2334915/
Bowler J., Lilley T.J., Pittam J.D., Wakeling A.E. Novel steroidal pure antiestrogens. Steroids. 1989;54(1):71–99. https://doi.org/10.1016/0039-128x(89)90076-7..
DOI: 10.1016/0039-128x(89)90076-7
Wakeling A.E., Dukes M., Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991;51(15):3867–3873. Available at: https://pubmed.ncbi.nlm.nih.gov/1855205/.https://pubmed.ncbi.nlm.nih.gov/1855205/
Dauvois S., White R., Parker M.G. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci. 1993;106(Pt 4):1377–1388. https://doi.org/10.1242/jcs.106.4.1377..
DOI: 10.1242/jcs.106.4.1377
Osborne C.K., Wakeling A., Nicholson R.I. Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br J Cancer. 2004;90(1 Suppl.):S2–S6. https://doi.org/10.1038/sj.bjc.6601629..
DOI: 10.1038/sj.bjc.6601629
Howell A., Osborne C.K., Morris C., Wakeling A.E. ICI 182,780 (Faslodex): development of a novel, “pure” antiestrogen. Cancer. 2000;89(4):817–825. https://doi.org/10.1002/1097-0142(20000815)89:4<817::aid-cncr14>3.0.co;2-6..
DOI: 10.1002/1097-0142(20000815)89:4<817::aid-cncr14>3.0.co;2-6
Tzukerman M.T., Esty A., Santiso-Mere D., Danielian P., Parker M.G., Stein R.B. et al. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol. 1994;8(1):21–30. https://doi.org/10.1210/mend.8.1.8152428..
DOI: 10.1210/mend.8.1.8152428
Nicholson R.I., Gee J.M., Manning D.L., Wakeling A.E., Montano M.M., Katzenellenbogen B.S. Responses to pure antiestrogens (ICI 164384, ICI 182780) in estrogen-sensitive and -resistant experimental and clinical breast cancer. Ann N Y Acad Sci. 1995;761:148–163. https://doi.org/10.1111/j.1749-6632.1995.tb31376.x..
DOI: 10.1111/j.1749-6632.1995.tb31376.x
Harrison M., Laight A., Clarke D., Giles P., Yates Y. Pharmacokinetics and metabolism of fulvestrant after oral, intravenous and intramuscular administration in healthy volunteers. EJC. 2003;1(5):S171. https://doi.org/10.1016/s1359-6349(03)90596-9..
DOI: 10.1016/s1359-6349(03)90596-9
Robertson J.F., Harrison M.P. Equivalent single-dose pharmacokinetics of two different dosing methods of prolonged-release fulvestrant (‘Faslodex’) in postmenopausal women with advanced breast cancer. Cancer Chemother Pharmacol. 2003;52(4):346–348. https://doi.org/10.1007/s00280-003-0643-7..
DOI: 10.1007/s00280-003-0643-7
McCormack P., Sapunar F. Pharmacokinetic profile of the fulvestrant loading dose regimen in postmenopausal women with hormone receptor–positive advanced breast cancer. Clin Breast Cancer. 2008;8(4):347–351. https://doi.org/10.3816/CBC.2008.n.040..
DOI: 10.3816/CBC.2008.n.040
Ohno S., Rai Y., Iwata H., Yamamoto N., Yoshida M., Iwase H. et al. Three dose regimens of fulvestrant in postmenopausal Japanese women with advanced breast cancer: results from a double-blind, phase II comparative study (FINDER1). Ann Oncol. 2010;21(12):2342–2347. https://doi.org/10.1093/annonc/mdq249..
DOI: 10.1093/annonc/mdq249
Howell A., Robertson J.F., Quaresma Albano J., Aschermannova A., Mauriac L., Kleeberg U.R. et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol. 2002;20(16):3396–3403. https://doi.org/10.1200/JCO.2002.10.057..
DOI: 10.1200/JCO.2002.10.057
Osborne C.K., Pippen J., Jones S.E., Parker L.M., Ellis M., Come S. et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol. 2002;20(16):3386–3395. https://doi.org/10.1200/JCO.2002.10.058..
DOI: 10.1200/JCO.2002.10.058
Howell A., Robertson J.F., Abram P., Lichinitser M.R., Elledge R., Bajetta E. et al. Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. J Clin Oncol. 2004;22(9):1605–1613. https://doi.org/10.1200/JCO.2004.02.112..
DOI: 10.1200/JCO.2004.02.112
Di Leo A., Jerusalem G., Petruzelka L., Torres R., Bondarenko I.N., Khasanov R. et al. Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptorpositive advanced breast cancer. J Clin Oncol. 2010;28(30):4594–4600. https://doi.org/10.1200/JCO.2010.28.8415..
DOI: 10.1200/JCO.2010.28.8415
Di Leo A., Jerusalem G., Petruzelka L., Torres R., Bondarenko I.N., Khasanov R. et al. Final overall survival: fulvestrant 500 mg vs 250 mg in the randomized CONFIRM trial. J Natl Cancer Inst. 2014;106(1):djt337. https://doi.org/10.1093/jnci/djt337..
DOI: 10.1093/jnci/djt337
Robertson J.F., Llombart-Cussac A., Rolski J., Feltl D., Dewar J., Macpherson E. et al. Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study. J Clin Oncol. 2009;27(27):4530–4535. https://doi.org/10.1200/JCO.2008.21.1136..
DOI: 10.1200/JCO.2008.21.1136
Robertson J.F., Bondarenko I.M., Trishkina E., Dvorkin M., Panasci L., Manikhas A. et al. Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial. Lancet. 2016;388(10063):2997–3005. https://doi.org/10.1016/S0140-6736(16)32389-3..
DOI: 10.1016/S0140-6736(16)32389-3
Goetz M.P., Toi M., Campone M., Sohn J., Paluch-Shimon S., Huober J. et al. MONARCH 3: abemaciclib as initial therapy for advanced breast cancer. J Clin Oncol. 2017;35(32):3638–3646. https://doi.org/10.1200/JCO.2017.75.6155..
DOI: 10.1200/JCO.2017.75.6155
Finn R.S., Martin M., Rugo H.S., Jones S., Im S.A., Gelmon K. et al. Palbociclib and letrozole in advanced breast cancer. N Engl J Med. 2016;375(20):1925–1936. https://doi.org/10.1056/NEJMoa1607303..
DOI: 10.1056/NEJMoa1607303
Hortobagyi G.N., Stemmer S.M., Burris H.A., Yap Y.S., Sonke G.S., PaluchShimon S. et al. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer. N Engl J Med. 2016;375(18):1738–1748. https://doi.org/10.1056/NEJMoa1609709..
DOI: 10.1056/NEJMoa1609709
Sledge G.W. Jr, Toi M., Neven P., Sohn J., Inoue K., Pivot X. et al. MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2-advanced breast cancer who had progressed while receiving endocrine therapy. J Clin Oncol. 2017;35(25):2875–2884. https://doi.org/10.1200/JCO.2017.73.7585..
DOI: 10.1200/JCO.2017.73.7585
Cristofanilli M., Turner N.C., Bondarenko I., Ro J., Im S.A., Masuda N. et al. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol. 2016;17(4):425–439. https://doi.org/10.1016/S1470-2045(15)00613-0..
DOI: 10.1016/S1470-2045(15)00613-0
Slamon D.J., Neven P., Chia S., Fasching P.A., De Laurentiis M., Im S.A. et al. Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3. J Clin Oncol. 2018;36(24):2465–2472. https://doi.org/10.1200/JCO.2018.78.9909..
DOI: 10.1200/JCO.2018.78.9909
Llombart-Cussac A., Pérez-García J.M., Bellet M., Dalenc F., Gil-Gil M., RuízBorrego M. et al. PARSIFAL Steering Committee and Trial Investigators. Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor-Positive, ERBB2-Negative Advanced Breast Cancer: A Randomized Clinical Trial. JAMA Oncol. 2021;7(12):1791–1799. https://doi.org/10.1001/jamaoncol.2021.4301..
DOI: 10.1001/jamaoncol.2021.4301
Johnston S.R., Kilburn L.S., Ellis P., Dodwell D., Cameron D., Hayward L. et al. Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial. Lancet Oncol. 2013;14(10):989–998. https://doi.org/10.1016/S1470-2045(13)70322-X..
DOI: 10.1016/S1470-2045(13)70322-X
Fribbens C., O’Leary B., Kilburn L., Hrebien S., Garcia-Murillas I., Beaney M. et al. Plasma ESR1 mutations and the treatment of estrogen receptorpositive advanced breast cancer. J Clin Oncol. 2016;34(25):2961–2968. https://doi.org/10.1200/JCO.2016.67.3061..
DOI: 10.1200/JCO.2016.67.3061
Giuliano M., Schettini F., Rognoni C., Milani M., Jerusalem G., Bachelot T. et al. Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis. Lancet Oncol. 2019;20(10):1360–1369. https://doi.org/10.1016/S1470-2045(19)30420-6..
DOI: 10.1016/S1470-2045(19)30420-6
Wilson F.R., Varu A., Mitra D., Cameron C., Iyer S. Systematic review and network meta-analysis comparing palbociclib with chemotherapy agents for the treatment of postmenopausal women with HR-positive and HER2-negative advanced/metastatic breast cancer. Breast Cancer Res Treat. 2017;166(1):167–177. https://doi.org/10.1007/s10549-017-4404-4..
DOI: 10.1007/s10549-017-4404-4
André F., Ciruelos E., Rubovszky G., Campone M., Rugo H.S., Iwata H. et al. Alpelisib for PIK3CA-mutated, hormone receptor–positive advanced breast cancer. N Engl J Med. 2019;380(20):1929–1940. https://doi.org/10.1056/NEJMoa1813904..
DOI: 10.1056/NEJMoa1813904
Rugo H.S., Neven P., Saffie I., Park Y.H., De Laurentiis M., Lerebours F. et al. Alpelisib + fulvestrant in patients with PIK3CA-mutated, HR+, HER2– advanced breast cancer (ABC) who received chemotherapy or endocrine therapy (ET) as immediate prior treatment: BYLieve Cohort C primary results and exploratory biomarker analyses. Cancer Res. 2022;82(4):PD13–05. https://doi.org/10.1158/1538-7445.SABCS21-PD13-05..
DOI: 10.1158/1538-7445.SABCS21-PD13-05